27 research outputs found
Osservazioni sulle forme della lettura di Platone tra gli eruditi bizantini e sulla trasmissione del testo della Appendix degli Apocrifi del corpus platonico (con note paleografiche sul Vat. Pal. Gr. 173 e sul Vat. Pal. Gr. 174)
No full textStoria della tradizione dell'Appendix platonica a Bisanzio attraverso alcuni dei testimoni più significativi, tra gli altri il Vat. Pal. gr. 173, per il quale si propone una nuova lettura, il Vat. Pal. gr. 174 attribuito qui a Isacco Argir
A church in Argir, Faroe Islands: On this rock I will build my church.
No full textThe following thesis presents the program, the design process and the resulting final design proposal of a church located on the Faroe Islands. The thesis investigates how architecture and religion corelates and how this can and will function in the place and culture of the Faroe Islands - more specifically the city of Argir.Religion is an important aspect of the Faroese culture and is to this day one of the main common denominators that brings the community together. This has served as one of the main design drivers and have been an important part of the justification of certain elements within the process.With the isolated location of the islands, the selection of materials is to some extend limited but this has however led to a precise and interesting vernicular architecture that has been used as references and inspiration through the process.Through studies, investigations and on-site registrations, the physical form of a constellation of relevant buildings - a church, a community house and a chapel - have come to light. The iterative process has led to many different iterations and proposals that are build upon emperical knowledge stemming from these investigations.The architecture has been designed with a special focus on the lighting conditions, the acoustics and the structural system and of course the impact of the surrounding nature on site
Adquisicions del Gabinet Numismàtic de Catalunya MNAC
No full textLa integració del Gabinet Numismàtic de Catalunya en el Museu Nacional d'Art de Catalunya ha permès emprendre una política d'adquisició de peces destinada a completar la col·lecció amb monedes de rellevant prestigi internacional.
Presentem les quatre monedes adquirides recentment. El Nomisma Histamenon de Roma III Argir (1028-1034), de la seca de Constantinoble, el qual va ser de gran valor durant el segle XI; el florí d'or de Florència, del 1434, el precedent del florí de la corona d'Aragó; el coronat de Ferran I de Nàpols (1458- 1494), com a document d'una escena històrica; i el tàler de l'arxiduc Leopold d’Àustria (1607-1632), de la casa de Hall, que va ser una important divisa de plata durant l'Edat Moderna.La integración del Gabinete Numismático de Cataluña en el Museu Nacional d'Art de Catalunya ha permitido emprender una política de adquisición de piezas, destinada a completar la colección con monedas de relevante prestigio internacional.
Presentamos las cuatro monedas recientemente adquiridas. El Nomisma Histamenon de Romano III Argiro (1028-1034), de la ceca de Constantinopla, fue de gran valor durante el siglo XI; el florín de oro de Florencia de 1434, precedente del florín de la Corona de Aragón; el "coronato" de Fernando I de Nápoles (1458-1494), como documento de una escena histórica; y el táler del archiduque Leopoldo de Austria (1607-1632), de la ceca de Hall, que fue una importante divisa de plata durante la Edad Moderna.The integration of the Numismatic Division of Catalonia in the Museu Nacional d' Art de Catalunya has allowed to take on a policy of acquisitions of numismatic items, mainly to complete the collection with coins of great internacional prestige.
We show you the four recently bought coins. The Nomisma Histamenon of Romanus III Argyrus (1028-1034), from the Constantinople mint; it had great value during the 11th century; the golden florin from Florence of 1434, the previous florin of the Crown of Aragon; the "coronato" of Fernando I of Napoli (1458-1494), as a documment of a historic scene; and the "tàler" of the Archduke Leopold of Austria (1607-1632) from the Hall mint, an important silver coin during the Modern Age
S-GENOTYPING OF SOME SWEET CHERRY CULTIVARS RELEASED WITHIN BREEDING PROGRAMMES IN THE BALKAN REGION
No full textSweet cherry cultivars generally exhibit S-ribonuclease (S-RNase)-based gametophytic selfincompatibility and require pollination with pollen of compatible genotypes, which are indispensable to stable fruit production. Therefore, the determination of S-genotype provides relevant information for sweet cherry breeders and growers. The aim of this study was to identify the S-allelic constitution and incompatibility group in eight sweet cherry cultivars which were named and released at Fruit Research Institute, Čačak, Republic of Serbia (‘Asenova Rana’ and ‘Čarna’), Research Station for Fruit Growing, Iasi, Romania (ʻAlexusʼ, ʻBuciumʼ and ʻMargoniaʼ) and Fruit Growing Institute, Plovdiv, Republic of Bulgaria (ʻKossaraʼ, ʻRosalinaʼ and ʻRositaʼ). The use of the polymerase chain reaction (PCR) method with consensus primers for the second introns of S-RNase, as well as primers specific for S1S7 and S9 alleles enabled determination of the following S-genotypes in the assessed cultivars: S1S2 (ʻAlexusʼ), S1S4 (ʻČarnaʼ), S2S9 (ʻKossaraʼ and ʻRositaʼ), S3S6 (ʻBuciumʼ), S3S9 (ʻAsenova Ranaʼ and ʻRosalinaʼ) and S5S6 (ʻMargoniaʼ). In addition, the S-genotypes of two parental cultivars were reported in this manuscript for the first time ‘Boambe de Cotnari’ (S2S7) and ‘Ranna Tcherna’ (S1S2). Based on the obtained S-allelic constitutions, the assessed cultivars were assigned to the following incompatibility groups: I, II, VI, IX, XI, XIV, XV, XVI and XLIII. The results generated in this study provide a valuable resource for cross design in developing new cultivars and for orchard management in the efficient high-yielding fruit production
Giant postinfarction posterolateral left ventricular aneurysm, complicated by mitral insufficiency
No full textIschemic heart disease holds the leading position in the structure of cardiovascular diseases. Early reperfusion therapy for acute myocardial infarction led to a decrease in mortality and severe complications of coronary artery disease. Despite advances in the treatment of coronary artery disease, dilatation and remodeling of the left ventricle develop in 20% of patients who have had a heart attack, leading to mitral insufficiency and systolic dysfunction of the left ventricle. Aneurysm of the left ventricle is a delayed severe complication of myocardial infarction, which significantly worsens the prognosis. Large aneurysms of the left ventricle cause progressive dilatation of the left ventricle, its volumetric overload with an increase in wall tension in the non-infarction zone, decreased functional characteristics of the left ventricle, thrombosis in the aneurysm cavity, life-threatening arrhythmias, and sudden death. Postinfarction left ventricular remodeling can lead to secondary mitral regurgitation, which is an independent predictor of mortality in the longterm period. Surgical treatment of coronary heart disease and its complications is one of the main problems of modern cardiovascular surgery
Surgical Remodeling of the Left Ventricle in Patients with Post-Infarction Dilation and Heart Failure
No full textINTRODUCTION The cause of heart failure in patients with coronary artery disease after anterior myocardial infarction may be dilatation of the cavity of the left ventricle (LV) with subsequent unfavorable course of the disease. In the case of early reperfusion, which prevents transmural myocardial necrosis, the damaged segment more often becomes akinetic than dyskinetic. Surgical remodeling of the left ventricle (SRLV) is aimed at reducing the volume and restoring its elliptical shape by eliminating scars in the akinetic and/or dyskinetic segments.AIM OF STUDY To evaluate the survival of patients with chronic heart failure (CHF) who had anterior wall myocardial infarction in the early and late periods after surgical remodeling of the left ventricle, in combination with coronary bypass grafting and/or interventions on the mitral valve.MATERIAL AND METHODS The study included 99 patients with coronary artery disease (CAD) who had myocardial infarction of the anterior LV wall and with severe heart failure, who underwent surgical LV remodeling in the period from 2002 to 2020. The analysis of early and long-term results was carried out. The risk factors influencing lethality were determined.The mean age of the patients was 56.0±10.2 years (from 23 to 81 years). The vast majority of patients (90%) were men. LV ventriculoplasty was combined with coronary bypass grafting in 97 (98%) patients, with mitral valve repair in 2 (2%) patients, with mitral valve replacement in 2 (2%) patients.RESULTS In the early postoperative period, all patients showed an improvement in global LV systolic function. The ejection fraction (EF) of the left ventricle increased from the average preoperative average value of 34.2±3.7% to 43±4.2% in the postoperative period (р<0,001). Left ventricular end systolic volume index (LVESV) decreased from 71.4±15.3 ml/m2 to 43.8±9.6 ml/m2, respectively (р<0,001). In the early postoperative period, 5 (5%) patients used the following means of mechanical hemodynamic support: intra-aortic balloon pump (IABP), non-implantable device for temporary support of the left ventricle (LVAD) and extracorporeal membrane oxygenation (ECMO). The 30-day mortality rate after LVESV was 6%. Prior to surgery, all patients had NYHA functional class (FC) III or IV. In the postoperative period, all patients experienced regression of heart failure symptoms and improved exercise tolerance. NYHA functional class improved to I and II in 100% of cases. Using univariate analysis, it was possible to determine that EF ≤30%, LVESV ≥80 ml/m2 and pulmonary artery pressure (PAP) >60 mm Hg. were risk factors for hospital mortality. The overall fifteen-year survival rate was 59.8±0.13%. The absence of readmission to the hospital due to recurrent angina pectoris, mitral valve dysfunction and progression of heart failure (HF) was 72% among surviving patients.CONCLUSION Surgical remodeling reduces the volume of the dilated left ventricle and restores its elliptical shape in patients with CAD after anterior myocardial infarction. The results of our study demonstrate an improvement in LV systolic function in all patients in the early postoperative period and low mortality, an acceptable fifteen-year survival rate, and a low readmission rate due to the progression of chronic heart failure (CHF)
Inhospital changes of left ventricular diastolic function in patients undergoing coronary bypass surgery
No full textAim. To evaluate changes of left ventricular (LV) diastolic function in patients with multivessel coronary artery disease before coronary artery bypass grafting (CABG) and in the early postoperative period (7-10 days), as well as to assess the relation- ship between diastolic LV dysfunction and postoperative atrial fibrillation (POAF).Material and methods. This original prospective study of included 50 patients undergoing CABG at the Cardiac Surgery Unit № 1 of the N. V. Sklifosovsky Research Institute for Emergency Medicine from December 2020 to December 2021. All patients underwent standard echocardiography before and after surgery. Diastolic function was assessed using the following parameters: septal mitral annulus velocity (e’septal), lateral mitral annulus velocity (e’lateral), the ratio of the peak early transmitral velocity to peak early diastolic velocity of the mitral annulus movement (E/e’), left atrial volume index (ml/m2), peak tricuspid regurgitation velocity (m/s), the ratio of the peak early to late filling velocity (E/A).Results. After CABG, 35 patients maintained sinus rhythm in the early postoperative period (group 1), while 15 patients had POAF (group 2). According to echocardiography, type 1 diastolic dysfunction prevailed in both groups; types 2 and 3 LV diastolic dysfunction were not identified. Among the parameters characterizing myocardial relaxation, in group 1 after CABG, a significant increase in the peak E (p=0,001) was noted, and due to this, the normalization of the E/A ratio was recorded (p<0,0001). An increase in e’lateral (p=0,05) was also revealed, in connection with which an increase in the E/e’ (p=0,02) was noted. In the group of patients with POAF, such changes were not detected. Left atrial volume index (ml/ m2) was significantly higher in the POAF group (p=0,02).Conclusion. Surgical myocardial revascularization has a positive effect on LV diastolic function. Improvement in LV diastolic function after CABG may be a sign of the restoration of hibernating myocardium function, while the absence of LV diastolic function improvement, together with left atrial dilatation, may be predictors of early POAF
S-genotyping of some sweet cherry cultivars released within breeding programmes in the Balkan region
No full textSweet cherry cultivars generally exhibit S-ribonuclease (S-RNase)-based gametophytic selfincompatibility and require pollination with pollen of compatible genotypes, which are indispensable to stable fruit production. Therefore, the determination of S-genotype provides relevant information for sweet cherry breeders and growers. The aim of this study was to identify the S-allelic constitution and incompatibility group in eight sweet cherry cultivars which were named and released at Fruit Research Institute, Čačak, Republic of Serbia (‘Asenova Rana’ and ‘Čarna’), Research Station for Fruit Growing, Iasi, Romania (ʻAlexusʼ, ʻBuciumʼ and ʻMargoniaʼ) and Fruit Growing Institute, Plovdiv, Republic of Bulgaria (ʻKossaraʼ, ʻRosalinaʼ and ʻRositaʼ). The use of the polymerase chain reaction (PCR) method with consensus primers for the second introns of S-RNase, as well as primers specific for S1-S7 and S9 alleles enabled determination of the following S-genotypes in the assessed cultivars: S1S2 (ʻAlexusʼ), S1S4 (ʻČarnaʼ), S2S9 (ʻKossaraʼ and ʻRositaʼ), S3S6 (ʻBuciumʼ), S3S9 (ʻAsenova Ranaʼ and ʻRosalinaʼ) and S5S6 (ʻMargoniaʼ). In addition, the S-genotypes of two parental cultivars were reported in this manuscript for the first time - ‘Boambe de Cotnari’ (S2S7) and ‘Ranna Tcherna’ (S1S2). Based on the obtained S-allelic constitutions, the assessed cultivars were assigned to the following incompatibility groups: I, II, VI, IX, XI, XIV, XV, XVI and XLIII. The results generated in this study provide a valuable resource for cross design in developing new cultivars and for orchard management in the efficient high-yielding fruit production
Хирургическая реконструкция левого желудочка у пациентов с постинфарктной дилатацией и сердечной недостаточностью
No full textINTRODUCTION The cause of heart failure in patients with coronary artery disease after anterior myocardial infarction may be dilatation of the cavity of the left ventricle (LV) with subsequent unfavorable course of the disease. In the case of early reperfusion, which prevents transmural myocardial necrosis, the damaged segment more often becomes akinetic than dyskinetic. Surgical remodeling of the left ventricle (SRLV) is aimed at reducing the volume and restoring its elliptical shape by eliminating scars in the akinetic and/or dyskinetic segments.AIM OF STUDY To evaluate the survival of patients with chronic heart failure (CHF) who had anterior wall myocardial infarction in the early and late periods after surgical remodeling of the left ventricle, in combination with coronary bypass grafting and/or interventions on the mitral valve.MATERIAL AND METHODS The study included 99 patients with coronary artery disease (CAD) who had myocardial infarction of the anterior LV wall and with severe heart failure, who underwent surgical LV remodeling in the period from 2002 to 2020. The analysis of early and long-term results was carried out. The risk factors influencing lethality were determined.The mean age of the patients was 56.0±10.2 years (from 23 to 81 years). The vast majority of patients (90%) were men. LV ventriculoplasty was combined with coronary bypass grafting in 97 (98%) patients, with mitral valve repair in 2 (2%) patients, with mitral valve replacement in 2 (2%) patients.RESULTS In the early postoperative period, all patients showed an improvement in global LV systolic function. The ejection fraction (EF) of the left ventricle increased from the average preoperative average value of 34.2±3.7% to 43±4.2% in the postoperative period (р<0,001). Left ventricular end systolic volume index (LVESV) decreased from 71.4±15.3 ml/m2 to 43.8±9.6 ml/m2, respectively (р<0,001). In the early postoperative period, 5 (5%) patients used the following means of mechanical hemodynamic support: intra-aortic balloon pump (IABP), non-implantable device for temporary support of the left ventricle (LVAD) and extracorporeal membrane oxygenation (ECMO). The 30-day mortality rate after LVESV was 6%. Prior to surgery, all patients had NYHA functional class (FC) III or IV. In the postoperative period, all patients experienced regression of heart failure symptoms and improved exercise tolerance. NYHA functional class improved to I and II in 100% of cases. Using univariate analysis, it was possible to determine that EF ≤30%, LVESV ≥80 ml/m2 and pulmonary artery pressure (PAP) >60 mm Hg. were risk factors for hospital mortality. The overall fifteen-year survival rate was 59.8±0.13%. The absence of readmission to the hospital due to recurrent angina pectoris, mitral valve dysfunction and progression of heart failure (HF) was 72% among surviving patients.CONCLUSION Surgical remodeling reduces the volume of the dilated left ventricle and restores its elliptical shape in patients with CAD after anterior myocardial infarction. The results of our study demonstrate an improvement in LV systolic function in all patients in the early postoperative period and low mortality, an acceptable fifteen-year survival rate, and a low readmission rate due to the progression of chronic heart failure (CHF).ВВЕДЕНИЕ Причиной сердечной недостаточности (СН) у пациентов с ишемической болезнью сердца (ИБС) после перенесенного переднего инфаркта миокарда может быть дилатация полости левого желудочка (ЛЖ) с последующим неблагоприятным течением заболевания. В случае ранней реперфузии, которая предотвращает трансмуральный некроз миокарда, поврежденный сегмент чаще становится акинетическим, чем дискинетическим. Хирургическая реконструкция ЛЖ (ХР ЛЖ) направлена на уменьшение объема и восстановление его эллиптической формы за счет исключения рубцов в акинетических и (или) дискинетических сегментах.ЦЕЛЬ ИССЛЕДОВАНИЯ Оценить выживаемость пациентов с хронической СН, перенесших инфаркт миокарда передней стенки в раннем и отдаленном периодах после ХР ЛЖ, в сочетании с коронарным шунтированием (КШ) и (или) вмешательствами на митральном клапане (МК).МАТЕРИАЛ И МЕТОДЫ В исследование включены 99 пациентов с ИБС, перенесших инфаркт миокарда передней стенки ЛЖ и с выраженной СН, которым выполняли хирургическую реконструкцию ЛЖ в период с 2002 по 2020 год. Проведен анализ ранних и отдаленных результатов. Определены факторы риска, влияющие на летальность.Средний возраст пациентов составил 56,0±10,2 года (от 23 лет до 81 года). Подавляющее большинство пациентов (90%) были мужчинами. Вентрикулопластика ЛЖ сочеталась с КШ у 97 пациентов (98%), с пластикой МК — у 2 пациентов (2%), с протезированием МК — у 2 пациентов (2%).РЕЗУЛЬТАТЫ В раннем послеоперационном периоде у всех пациентов отмечено улучшение глобальной систолической функции ЛЖ. Фракция выброса (ФВ) ЛЖ в послеоперационном периоде статистически значимо возросла со среднего дооперационного среднестатистического значения — с 34,2±3,7 до 43±4,2% (р<0,001). Индекс конечного систолического объема (ИКСО) ЛЖ статистически значимо снизился соответственно с 71,4±15,3 до 43,8±9,6 мл/м2 (р<0,001). В раннем послеоперационном периоде у 5 пациентов (5%) использовали следующие средства механической поддержки гемодинамики: внутриаортальную баллонную контрпульсацию, не имплантируемый аппарат для временной поддержки ЛЖ (LVAD) и экстракорпоральную мембранную оксигенацию. 30-дневная летальность после ХР ЛЖ составила 6%. До операции у всех пациентов был III или IV функциональный класс (ФК) сердечной недостаточности по NYHA. В послеоперационном периоде у всех пациентов наблюдали регрессирование явлений СН и улучшение переносимости физической нагрузки. ФК по NYHA улучшился до I и II во всех случаях. С помощью одномерного анализа удалось определить, что ФВ не более 30%, ИКСО не менее 80 мл/м2 и давление в легочной артерии не менее 60 мм рт.ст. являлись факторами риска госпитальной летальности. Общая 15-летняя выживаемость составила 59,8±0,13%. Отсутствие повторной госпитализации в стационар в связи с рецидивом стенокардии, дисфункцией МК и прогрессированием СН составило 72% среди выживших пациентов.ВЫВОДЫ Хирургическая реконструкция уменьшает объем дилатированного левого желудочка и восстанавливает его эллиптическую форму у пациентов с ишемической болезнью сердца, перенесших передний инфаркт миокарда. Результаты нашего исследования демонстрируют улучшение систолической функции левого желудочка у всех пациентов в раннем послеоперационном периоде и низкую летальность, приемлемую пятнадцатилетнюю выживаемость и низкую частоту повторных госпитализаций в связи с прогрессированием хронической сердечной недостаточности
Enhancing the understanding of fragmentation processes in hadrontherapy and radioprotection in space with the FOOT experiment
No full textDuring proton and carbon ions cancer treatment, nuclear interactions of the beam nuclei with the patient tissues always occur: the former leads to target fragmentation only, the latter to both projectile and target fragments production. In proton therapy the low-energy, high-charge and therefore short-range fragments produced along the beam path in the target fragmentation process may have higher biological effectiveness compared to protons, resulting in a not negligible effect on the delivered dose in a region before the tumor site. In carbon treatments the long range of projectile fragments results in a dose deposition in the healthy tissues behind the tumor site. Therefore, precise fragmentation cross section data would be of great importance to further optimize treatments. At the same time, such data would help improving the design of the shielding of spaceships, especially in view of long distance travels (i.e. Mars human exploration). In fact, nuclear fragmentation occurring between the space background radiation and spacecrafts materials changes the composition of the radiation field and thus the dose received by the astronauts. The FOOT (FragmentatiOn Of Target) experiment has been designed to investigate nuclear fragmentation processes of interest for particle therapy and space radiation protection with a precision in the cross section measurements around 5%. In this work the physics motivations of FOOT and the final design of the experiment will be presented. A performances study of the electronic setup based on FLUKA Monte Carlo simulations and a preliminary analysis of experimental data are reported as well
