138 research outputs found
Topology-dependent dissociation mode of the O-H bond in monohydroxycoumarins
No full textAll possible monohydroxycoumarin derivatives are modeled using density functional theory computations in order to investigate the role of the hydroxyl group position for the radical-scavenging and antioxidant activity of these compounds. Geometry optimization is performed using the B3LYP functional with the 6-311++G(d,p) basis set. The enthalpy changes are assessed in gas phase and in implicit water using the polarized continuum model. Structure-reactivity patterns are delineated. The most reactive isomers as well as the most probable mechanism of interaction between monohydroxycoumarins and free radicals are outlined. © 2019 American Chemical Society
Agricultural Academy
No full textAbstract UZUNOVA, E., M. GEORGIEVA, M. NIKOLOVA, S. STUDENKOV and I. TRAYKOV, 2010. Pumpkinseed (Lepomis gibbosus) distribution and abundance in litoral zones of Sand -Pit Lakes. Bulg. J. Agric. Sci., The distribution and abundance of invasive fish species Lepomis gibbosus L. inhabiting littoral zones of sandpit lakes was investigated. The study was carried out during May and June -in active breeding period for pumpkinseeds. The investigated water bodies are located along the Lesnovska River, tributary of Iskar River, Danube drainage basin. The pumpkinseed was observed in all water bodies except Chepintci Lake. The mean abundance of pumpkinseed varied between 0.2 and 24.5 (CPUE). The highest abundance was recorded in Negovan Lake. The mean total length of pumpkinseed was relatively low for all investigated sites and varied between 4.9 and 7.4 cm, corresponding to an average age of 0.7 and 2.09 years respectively. The character of a bottom and density of water vegetation significantly correlated with pumpkinseed abundance
ENGINES FOR SEARCHING THE INTERNET
No full textAfter a fifteen-year period of increasing interest on the part of the
author in engines used for searching for information on the Internet, this article discusses the changes which have taken place throughout this period of their development. The aim of this article is to note the major features of the most popular search engines around at the moment. Using the data presented in the article, the author draws conclusions about the current state of affairs and at the same time delineates perspectives for the development of search engines in the next few years. A special section has been included for comment on the principal recommendations of specialists regarding the optimisation of Internet sites which directly influences their indexing by search engines. On the basis of this, the author delineates the trends which have characterised search engines during this relatively long period of their life cycle
Unlocking the crystal ball: Deciphering recessions through dynamic relationships among leading indicators in Sweden
No full textForecasting economic recessions has been a major topic of interest for economists, decisionmakers and the public alike. In this study we ventured to analyse how changes in economic output or GDP is related to changes in consumer sentiment and house prices in the Swedish economy. For the purpose we employed simple vector autoregression (VAR) methodology that has the benefit of modelling dynamic relationships across time. Our results indicated that consumer sentiment, measured by Consumer Confidence Index, and housing prices, measured by the Housing Index, are indeed related to GDP meaning that these variables can be used for forecasting GDP and potentially be indicative of imminent recessions. Overall, this study contributes to the body of knowledge on economic forecasting and VAR methodologies.
Screening for mild cognitive impairment in patients with cardiovascular risk factors
No full textTeodora Yaneva-Sirakova,1 Latchezar Traykov,2 Julia Petrova,2 Ivan Gruev,3 Dobrin Vassilev1 1Department of Internal Medicine, Cardiology Clinic, 2Department of Neurology, Neurology Clinic, Medical University Sofia, 3Cardiology Clinic, National Transport Hospital “Tsar Boris III”, Sofia, Bulgaria Aim: Cardiovascular risk factors are also risk factors for cognitive impairment. They have cumulative effect in target organ damage. The precise correlation between cardiovascular risk factors and cognitive impairment, as well as assessing the extent to which they may affect cognitive functioning, is difficult to ascertain in everyday clinical practice. Quick, specific, and sensitive neuropsychological tests may be useful in screening for, and the prophylaxis of, target organ damage in hypertensive patients.Methods: We gathered full anamnesis, performed physical examination, laboratory screening and echocardiography. These variables were observed at office and home for all patients, For half of the patients, 24-hour ambulatory blood pressure monitoring and neuropsychological testing using Montreal Cognitive Assessment (MoCA), Mini Mental State Examination (MMSE), Geriatric Depression Scale, and the 4-instrumental activities of daily living scale were undertaken.Results: For a period of 2 years, 931 patients were included after applying the inclusion and exclusion criteria. The mean age was 65.90±10.00 years. Two hundred and sixty three patients (85 [32.32%] males and 178 [67.68%] females) were reevaluated after a mean follow-up period of 12 months (6–20 months). The mean results of MoCA and MMSE were significantly lower (p<0.05) in the group of patients with poorly controlled blood pressure and cardiovascular risk factors. There was mild to intermediate negative correlation between Systematic Coronary Risk Evaluation (SCORE) and the neuropsychological tests’ results.Conclusion: Cardiovascular risk factors play an important role for the development of cognitive impairment in the eastern European population because of their high frequency and interaction. The use of easily applicable neuropsychological tests in everyday clinical practice of specialties other than neurology may help in stratifying the risk for development and progression of mild cognitive impairment in this high-risk group. Keywords: arterial hypertension, cardiovascular risk factors, mild cognitive impairment, MoCA, pulse pressure, systolic pressur
Multitasking in Embedded System Designs
No full textIt is common knowledge in Information Technology (IT) that an embedded system is based on microprocessor and is built to control a function or a range of functions. Although, it is not designed to be programmed by the end user in the same way that a PC is, it is designed to perform one particular task with choices and different options [1-5]. Multitasking is a method by which multiple tasks, also known as processes, share common processing resources, such as CPU. The main aim of this paper is analysis of the design of the embedded systems and a focus on mid-level abstractions for concurrent programs
Interactive Approach to Learning of Sorting Algorithms
No full textToday we live in a society of high technologies, advanced information and com-munication systems in every field, including education. So, in modern education, teachers make full use of the possibilities of modern Information and Communi-cation Technologies (ICT). In this case, the attitude of the teachers towards the use of computers, to achieve the educational goals, is very important. To have the technologies sustained and significant effect, students in secondary and higher schools need to understand how to use them. The goal of this article is to help of students in secondary and higher schools to acquire enough practical program-ming skills and to learn the sorting algorithms, i.e. the article considers basic sort-ing algorithms. We developed and describe here software with name “Visual sorting” that shows visual, the execution of the basic sorting algorithms: Bubble sort; Selection sort; Insertion sort; Merge sort. Also, our software provides inter-active tracking of the performance (step by step) of different sorting algorithms
VARIETY OF CHEMILUMINESCENT METHODS FOR ANTIOXIDANT ACTIVITY: INVESTIGATION OF <i>CRATAEGUS OXYCANTHA</i> EXTRACT
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Results of a national survey ‘It’s time for Lp(a)’ regarding the awareness, attitudes and practices of bulgarian cardiologists for testing lipoprotein(a)
No full textЦел на проучването: „Време е за Lp(a)“ е проучване на Дружеството на кардиолозите в България (ДКБ) за оценка на нивото на познаване и използване на липопротеин(а) – Lp(a), и предизвикателствата, които ограничават извършването на такава липидна оценка. Методи и резултати: В периода юли-август 2024 г. ДКБ проведе онлайн национално допитване с въпроси в три области: професионална информация; информация за обстоятелства, при които кардиолозите обмислят изследване на Lp(a), и въпроси относно причините за ограничено препоръчване на теста. От 585 кардиолози, включили се в проучването, 189 са отговорили на всички въпроси, а 396 са отговорили частично. Делът на клиницистите, които декларират рутинно измерване на Lp(a) с цел стратификация на риска и при фамилна обремененост, е само 18%, като 50% от кардиолозите никога не измерват Lp(a). Най-честите причини да не поръчват изследване на Lp(a) според 55% от кардиолозите са отсъствието на теста в рутинната оценка на липидите и фактът, че изследването не се покрива от НЗОК (54%). От анкетираните 94% споделят, че биха използвали Lp(a), ако тестът е реимбурсиран. 48% от кардиолозите имат нужда от ясни клинични указания относно Lp(a). Според 64% наличието на терапии, насочени към този липопротеин, би довело до по-голяма употреба на теста за Lp(a). Заключение: Резултати показват необходимостта от допълнителни усилия от научните дружества за въвеждане на ясни и подробни клинични насоки, включване в липидни панели и реимбурсиране на изследването, както и образователни инициативи за справяне с ограниченото използване и признаване на Lp(a) за рисков фактор. Aim: “It’s Time for Lp(a)” is a survey of Bulgarian Society of Cardiology (BSC) assessing the awareness and use of lipoprotein(a) – Lp(a), and the challenges that limit this lipid assessment. Methods and results: In the period of July-August 2024, the BSC conducted an on-line national survey with questions in three areas: professional information; information on the clinical circumstances in which cardiologists are considering Lp(a) testing and questions about reasons for limited test recommendation. Of the 585 cardiologists who took part in the survey, 189 answered all of the questions, and 396 answered partially. Only 18% of clinicians declare that they routinely measure Lp(a) primarily for cardiovascular risk stratification and in cases of family history. Additionally, 50% of cardiologists never measure Lp(a) at all. The most common reasons for not referring patients for testing Lp(a), according to 55% of cardiologists, are its absence in standard lipid panel and the fact that the test is not reimbursed (54%). 94% of respondents say that they would use Lp(a) if the test was reimbursed. 48% of cardiologists need clear clinical guidance on the use of Lp(a). According to 64%, the availability of therapies targeting this lipoprotein would lead to a greater use of Lp(a) test. Conclusion: These results indicate the need for further efforts by scientific societies to introduce clear and detailed guidelines, inclusion in lipid panels and reimbursement of testing, as well as educational initiatives to address the limited use and recognition of Lp(a) as a risk factor
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