1,201 research outputs found
Sustainable Adjustment of Global Imbalances
No full textThis paper uses NIESR’s global econometric model, NiGEM, to analyse possible adjustment paths for the US current account, if its current level of 6 per cent of GDP proves unsustainable. Nominal exchange rate shifts have only a transitory impact on current account balances, so any long-term improvement of the US current account balance would require a real and sustained reduction in domestic absorption, or a rise in foreign absorption. This could be effected through a sequence of exchange rate movements driven by a gradual rise in the risk premium on US assets. This would induce a permanent change in the real exchange rate, and would also reduce domestic absorption in the US due to a rise in real interest rates. Global policy coordination, which involved raising domestic demand in countries such as China and Japan, could speed the process of adjustment and ease the negative impact on the US economy.global imbalances, real exchange rate realignment, risk premia, US current account
Late Roman amphora 1: a study of diversification
No full textThis paper draws on petrological work done by the author on the most important type of late Roman amphora - LR1, which was widely distributed in the Mediterranean, Red Sea area and western Britain
Letter from D.F. Goggin, Motor Officer, April 5, 1950
No full textIn this letter, D.F. Goggin, Motor Officer, affirms that Tsugitada Kanamori was employed by his organization starting June 8, 1946 and was still employed there at the time this letter was written. He remarks that Kanamori is a loyal and honest employee and recommends him for any position.This collection contains one box of documents belonging to Tsugitada Kanamori. Materials in this collection mostly pertain to Kanamori’s efforts regarding canceling his renunciation and reinstating his American citizenship
Reconstruction of turbulent pipe-flow profiles from laser Doppler velocimetry data
No full textLaser Doppler velocimetry (LDV) is a powerful experimental tool that finds increasing application in industrial research and product development. For example, LDV may be used to support the development of water, heat, and cooling meters as well as the design and validation of the associated testing and calibration facilities. For such applications, a basic quantity of interest is the volume flow rate Q that can be determined through numerical integration of the velocity profile over the measurement grid. However, under realistic experimental conditions, optical disturbances and reflections may cause corrupted and unreliable data at various measurement points. Here, we study a criterium to identify and reconstruct such data points. The reconstruction criterium is based on the standard error associated with each measurement point. Using some of our LDV data, we show that the error in Q with respect to a reference flow rate may be reduced significantly through the reconstruction. Consequently, the reconstruction criterium allows to establish accurate and reliable flow rates that have potential to be used as a primary validation reference
Letter from D.F. Goggin, Motor Officer, to the American Consul, Yokohama, Japan, April 18, 1951
No full textThis letter confirms that Tsugitada Kanamori has worked for D.F. Goggin since June 1946 at the time this letter was written and has been a model employee.This collection contains one box of documents belonging to Tsugitada Kanamori. Materials in this collection mostly pertain to Kanamori’s efforts regarding canceling his renunciation and reinstating his American citizenship
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
Het Ir. D.F. Woudagemaal: De relatie tussen de ingrepen in het Ir. D.F. Woudagemaal en de aanwijzingen als rijksmonument en werelderfgoed
No full textHet Ir. D.F. Woudagemaal is het grootste functionerende stoomgemaal ter wereld. Dankzij de technische en bouwkundige waarde, is het Woudagemaal in 1977 aangewezen als rijksmonument door de Rijksdienst voor het Cultureel Erfgoed (RCE). Jaren later, in 1998, is het door de United Nations Educational, Scientific and Cultural Organization (UNESCO) opgenomen in de werelderfgoedlijst. Dit betekent dat het stoomgemaal uniek is en absoluut niet verloren mag gaan. Sinds de oplevering in 1920 is het stoomgemaal van civiel ingenieur en architect Dirk Frederik Wouda (1880-1961) ieder jaar in gebruik gesteld. Door de jaren heen heeft het stoomgemaal enkele veranderingen ondergaan. Desalniettemin is de wisselwerking tussen de innovaties, conservering en de aanwijzing als erfgoed onderbelicht. Het doel van deze thesis is daarom om de volgende vraag te beantwoorden: wat is de relatie tussen de ingrepen in het Ir. D. F. Woudagemaal en de aanwijzingen als rijksmonument en werelderfgoed?AR2A011Architecture, Urbanism and Building Science
Estimación del exponente de Hurst y la dimensión fractal de una superficie topográfica a través de la extracción de perfiles
No full textFractal Geometry was created as an alternative to interpret and represent more accurately the different forms present in nature. Thus, in this article, which is born of the research Project grade entitled “Simulation of random fields type fractional brownian motion applied to the geosciences space observations study” presents an alternative to estímate of a surface the Hurst Exponent and its Fractal Dimension through the evaluation of some topographic profiles drawn from the same, the surface, which are presented as important parameters in this geometry. To achieve the goal was extracted in the first instance a mosaic of Digital Elevation Model generated from Colombia official plates at 1:100.000 scale, getting to the work surface representative values in the Hurst Exponent between 0.53 and 0.79, while on other side scored to the surface a characteristic value for the Fractal Dimension of 2.42, catalog allowing topographic surfaces as objects of fractal nature.La geometría fractal nace como una alternativa para interpretar y representar de manera más precisa las diferentes formas presentes en la naturaleza. Es así como en este artículo, el cual nace del trabajo de investigación del proyecto de grado titulado “Simulaciones de campos aleatorios tipo movimiento browniano fraccionado aplicadas al estudio de observables espaciales en geociencias” se presenta una alternativa para estimar el exponente de Hurst y la dimensión fractalde de una superficie a través de la evaluación de algunos perfiles topográficos extraídos de la misma, los cuales se presentan como parámetros importantes dentro de dicha geometría.Para lograr el objetivo se extrajo, en primera instancia, un mosaico del Modelo Digital de Elevación generado de las planchas oficiales de Colombia a escala 1:100.000, obteniendo para la superficie de trabajo valores representativos entre 0,53 y 0,79 en el exponente de Hurst, mientras que por otro lado se obtuvo un valor característico para la dimensión fractal de dicha superficie de 2,42; permitiendo así catalogar las superficies topográficas como objetos de naturaleza fractal
Descubrimiento de una escultura monolítica en el Cerro Mazatepetl, Magdalena Contreras, D.F.. 28. Arqueología
No full textGendrop, Paul, 1990. Arte prehispánico en Mesoamérica, México, Trillas, Centro de Investigaciones Arquitectónicas, Escuela Nacional de Arquitectura, UNAM, 1990.Nicholson, H.B., “The Chapultepec cliff sculpture of Moctezuma Xocoyotzin”, en: El México Antiguo, Revista internacional de Arqueología, Etnología, Folklore, Prehistoria, Historia Antigua y Lingüística mexicanas, t. IX, México, Sociedad Alemana Mexicanista de México, 1961, pp. 379-444.Santana Sandoval, Andrés, “La ceja azul o elemento ‘C’ en las pinturas murales de Cacaxtla y su significado”, en: Cacaxtla. Proyecto de Investigación y Conservación, México, Conaculta-Gobierno de Tlaxcala-INAH-Consejo estatal de Cultura, Tlaxcala, 1980a, pp. 53- 65.____, “El simbolismo de las pinturas murales del templo de Venus y el templo rojo”, en: Cacaxtla. Proyecto de Investigación y Conservación, México, Conaculta-Gobierno de Tlaxcala-INAH y Consejo estatal de Cultura Tlaxcala, 1990b, pp. 67-75.Santos Ramírez, Joel, “Informe parcial trabajos de exploración de la estructura ‘A’, del sitio Maztepetl, Cerro del Judío, Magdalena Contreras, D.F.”, en: Archivo del Proyecto Arqueológico, 2000, (mecanuscrito)
Bilateral and unilateral arm training improve motor function through differing neuroplastic mechanisms: a single-blinded randomized controlled trial
No full textBACKGROUND AND PURPOSE:
This randomized controlled trial tests the efficacy of bilateral arm training with rhythmic auditory cueing (BATRAC) versus dose-matched therapeutic exercises (DMTEs) on upper-extremity (UE) function in stroke survivors and uses functional magnetic resonance imaging (fMRI) to examine effects on cortical reorganization.
METHODS:
A total of 111 adults with chronic UE paresis were randomized to 6 weeks (3×/week) of BATRAC or DMTE. Primary end points of UE assessments of Fugl-Meyer UE Test (FM) and modified Wolf Motor Function Test Time (WT) were performed 6 weeks prior to and at baseline, after training, and 4 months later. Pretraining and posttraining, fMRI for UE movement was evaluated in 17 BATRAC and 21 DMTE participants.
RESULTS:
The improvements in UE function (BATRAC: FM Δ = 1.1 + 0.5, P = .03; WT Δ = -2.6 + 0.8, P < .00; DMTE: FM Δ = 1.9 + 0.4, P < .00; WT Δ = -1.6 + 0.7; P = .04) were comparable between groups and retained after 4 months. Satisfaction was higher after BATRAC than DMTE (P = .003). BATRAC led to significantly higher increase in activation in ipsilesional precentral, anterior cingulate and postcentral gyri, and supplementary motor area and contralesional superior frontal gyrus (P < .05). Activation change in the latter was correlated with improvement in the WMFT (P = .01).
CONCLUSIONS:
BATRAC is not superior to DMTE, but both rehabilitation programs durably improve motor function for individuals with chronic UE hemiparesis and with varied deficit severity. Adaptations in brain activation are greater after BATRAC than DMTE, suggesting that given similar benefits to motor function, these therapies operate through different mechanisms
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