2 research outputs found
Optimasi Formula Lotion Antinyamuk yang Mengandung Minyak Sereh Wangi (Cymbopogon nardus L.) Menggunakan Metode Desain Faktorial
No full textBackground: Mosquitoes can spread viruses, parasites, protozoa, and worms to human. There are many repellence that are made of chemicals that are not safe for the skin. Citronella oil is an effective ingredient at a concentration of 10% as a repellence in lotion preparations. Lotion is a liquid emulsion consisting of two phases, namely the oil phase and the water phase which are stabilized with an emulsifier, containing one or more active ingredients. In this study, optimization of the formula was carried out by varying the excipients concentration to determine its effect on the lotion formula. Objective: To analyze the effect of stearic acid (emulsifier), glycerin (emollient) and their interactions on the physical dosage form of citronella oil repellence lotion ant to evaluate optimum composition of citronella oil repellence lotion. Method: This research was an experimental study with a factorial design of 2 factors, which are stearic acid and glycerin at the maximum and the minimum levels of these 2 factors. The evaluation of the product included homogeneity, lotion spreadability, viscosity, pH, and stability tests at room temperature. The formula optimization parameters analyzed were the response of lotion spreadability and viscosity using Design Expert® 11. Result: The results showed that the citronella oil repellence lotion was homogeneous, pH in accordance with skin physiology of 4.5-6.5, showed adequate viscosity, and good spreadibility. The formula of F1, Fa, Fb, and Fab were stable at 12 weeks of storage. In this study, stearic acid gave the dominant effect on decreasing the spreadability by 62.90% and increasing the viscosity by 92.86%. The optimization of the formula showed that the optimum composition of stearic acid was 10.95 grams and glycerin was 8.16 grams, producing a viscosity of 7471. 73 cP and a spreadability of 6.42 cm. Conclusion: The optimization of the formula performed out on repellence lotion of citronella oil, stearic acid and glycerin, give an effect where stearic acid is dominant in reducing the spreadability and increasing viscosity with the optimum composition obtained for stearic acid is 10.95 grams and glycerin is 8.16 grams.79 HalamanSkripsi Sarjan
Optimasi Formula Lotion Antinyamuk yang Mengandung Minyak Sereh Wangi (Cymbopogon nardus L.) Menggunakan Metode Desain Faktorial
No full textBackground: Mosquitoes can spread viruses, parasites, protozoa, and worms to human. There are many repellence that are made of chemicals that are not safe for the skin. Citronella oil is an effective ingredient at a concentration of 10% as a repellence in lotion preparations. Lotion is a liquid emulsion consisting of two phases, namely the oil phase and the water phase which are stabilized with an emulsifier, containing one or more active ingredients. In this study, optimization of the formula was carried out by varying the excipients concentration to determine its effect on the lotion formula. Objective: To analyze the effect of stearic acid (emulsifier), glycerin (emollient) and their interactions on the physical dosage form of citronella oil repellence lotion ant to evaluate optimum composition of citronella oil repellence lotion. Method: This research was an experimental study with a factorial design of 2 factors, which are stearic acid and glycerin at the maximum and the minimum levels of these 2 factors. The evaluation of the product included homogeneity, lotion spreadability, viscosity, pH, and stability tests at room temperature. The formula optimization parameters analyzed were the response of lotion spreadability and viscosity using Design Expert® 11. Result: The results showed that the citronella oil repellence lotion was homogeneous, pH in accordance with skin physiology of 4.5-6.5, showed adequate viscosity, and good spreadibility. The formula of F1, Fa, Fb, and Fab were stable at 12 weeks of storage. In this study, stearic acid gave the dominant effect on decreasing the spreadability by 62.90% and increasing the viscosity by 92.86%. The optimization of the formula showed that the optimum composition of stearic acid was 10.95 grams and glycerin was 8.16 grams, producing a viscosity of 7471. 73 cP and a spreadability of 6.42 cm. Conclusion: The optimization of the formula performed out on repellence lotion of citronella oil, stearic acid and glycerin, give an effect where stearic acid is dominant in reducing the spreadability and increasing viscosity with the optimum composition obtained for stearic acid is 10.95 grams and glycerin is 8.16 grams.79 HalamanSkripsi Sarjan
