3,672 research outputs found

    PredIDR: Accurate prediction of protein intrinsic disorder regions using deep convolutional neural network

    No full text
    The involvement of protein intrinsic disorder in essential biological processes, it is well known in structural biology. However, experimental methods for detecting intrinsic structural disorder and directly measuring highly dynamic behavior of protein structure are limited. To address this issue, several computational methods to predict intrinsic disorder from protein sequences were developed and their performance is evaluated by the Critical Assessment of protein Intrinsic Disorder (CAID). In this paper, we describe a new computational method, PredIDR, which provides accurate prediction of intrinsically disordered regions in proteins, mimicking experimental X-ray missing residues. Indeed, missing residues in Protein Data Bank (PDB) were used as positive examples to train a deep convolutional neural network which produces two types of output for short and long regions. PredIDR took part in the second round of CAID and was as accurate as the top state-of-the-art IDR prediction methods. PredIDR can be freely used through the CAID Prediction Portal available at https://caid.idpcentral.org/portal or downloaded as a Singularity container from https://biocomputingup.it/shared/caid-predictors/

    Pak energiearmoede gericht aan

    No full text
    De verduurzaming van onze woningvoorraad is naast een technische operatie ook een verdelingsvraagstuk. Huishoudens met lage inkomens in slechte woningen moeten prioriteit krijgen bij het renovatiebeleid. En totdat iedereen in een duurzaam huis woont, moeten huishoudens die in de knel komen door hoge energieprijzen, worden gecompenseerd.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Urban Development Managemen

    Optimizing the remanence magnetism method for steel fracture detectionin structures - Theoretical development

    No full text
    Bei der Dissertation von Herrn Chol-I Pak handelt es sich um die Entwicklung der magnetostatischen Grundlagen für das zerstörungsfreie Remanenzmagnetismus-Verfahren. Das Remanenzmagnetismus-Verfahren wird zur Bruchortung von Spannbewehrungen in Bauwerken angewendet. Aufgrund komplizierter Bewehrungskonstellationen und ferromagnetischer Eigenschaften von Bewehrungen lassen sich Magnetfelder nicht einfach analysieren. Magnetfelder aus Bewehrungen können wegen ihrer gezogenen Form durch die Finite-Elemente-Methode häufig nur mit großen Schwierigkeiten modelliert und gelöst werden. Die theoretische Entwicklung dieses Verfahrens ist zur Erhöhung der Aussagekräftigkeit und Erweiterung des Einsatzgebiets notwendig. Das Ziel dieser Dissertation ist es, das aufmagnetisierende Feld des Großmagneten und das Remanenzfeld von Bewehrungen analytisch zu simulieren. Weiterhin wird theoretisches Basiswissen zur Analyse der Position und des Zustands von Bewehrungen erforscht. Um das gesamte magnetostatische System aus Großmagnet, Luft und verschiedenen Bewehrungen analytisch simulieren zu können, wird der Ansatz von magnetischen Ladungen bzw. magnetischen Monopolen eingesetzt, und es werden grundlegende Theorien für magnetische Monopole entwickelt. Diese Theorien werden zur Herleitung der Formeln zur Lokalisierung und Zustandsanalyse von Bewehrungen angewendet. Die hergeleiteten Formeln werden zuerst mit Ergebnissen aus FEM-Modellen verglichen. Zur Verifizierung der entwickelten Theorien werden dann Laborversuche durchgeführt und die Theorien, wenn erforderlich, modifiziert. Zuletzt wird die Überführung der hergeleiteten Formel in die praktische Anwendung dargestellt.This thesis develops the magneto static principles that are the basis for the non-destructive remanence magnetism method. The remanence magnetism method is used for fracture detection in the steel reinforcement of structures. Due to complicated reinforcement constellations and the ferromagnetic nature of the steel it is no simple task to analyze the magnetic fields. The magnetic fields of the reinforcing steel can often only be modelled and solved with great difficulty using finite element analysis due to their drawn form. The theoretical development of this method is necessary to increase its significance and expand its range of applications. The goal of this dissertation is to analytically simulate the magnetizing field of the large magnet and the remanence field of the reinforcement. Furthermore the basic theoretical knowledge for analyzing the position and condition of the reinforcing steel is explored. The proposal of magnetic charges, or rather magnetic monopoles and the basic theories of magnetic monopoles are developed to simulate the complete magneto static system of the large magnet, air envelope, and varying reinforcement types and constellations. These theories are utilized to derive formulas used for the localization and condition analysis of reinforcement. The derived formulas are first compared with the results from FEM models. To verify the developed theories laboratory tests are conducted and the theories, if necessary, are modified. Finally the implementation of the derived formulas into their practical applications are presented

    Forced vibrations of a mass on a nonlinear spring.

    Full text link
    Republic of Korea Navy author.http://archive.org/details/forcedvibrations109451223

    New Approach to 1:1 and 3:1 Internal Resonances

    No full text

    Colloidal engines for innovative tests of information thermodynamics

    Full text link
    Recent theoretical developments in information thermodynamics elucidated the link between the acquired information and the entropy production through measurement and feedback control by generalizing the fluctuation theorems and the second law of thermodynamics. We summarize here our recent experimental studies based on the colloidal system that have been conducted to test the theoretical findings of information thermodynamics. In particular, we present the design principles of error-free and noisy information engines consisting of a colloidal particle in an optical trap that is capable of performing nearly error-free measurement and ultrafast feedback control. Our perspectives on future experimental studies are also presented. ?? 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

    Formal report industrial with Tetra Pak

    No full text
    The author was assigned to Tetra Pak Global Informatino Management (TPIM) as s ServiceDesk engineer. Beside resolving problems and issues, the author was also assigned several projects involving physical network management, creation of a personnel database, checking of inventory as well as the authoring of software user-guides

    China - south coast, Tien Pak to Macao [cartographic material] /

    No full text
    Hydrographic chart of the South China Sea from Tien Pak Harbour to Macau. Relief shown by soundings and contours.; In lower left margin: Small corrections ... 1937-79.; In lower right margin: 2212.; Prime meridian: Greenwich.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map-brsc1. Insets: Hui-Ling-San Harbour. Scale [ca. 1:48,440] -- Haucheun Island, Namo Harbour. Scale [ca. 1:48,760] -- St. John Island, Shito Bay. Scale [ca. 1:48,120] -- Macao Harbour, from a Portuguese government plan of 1923. Scale [ca. 1:50,000]
    corecore