3,311 research outputs found
TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis
No full textPurpose: Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the pathogenesis of atherosclerosis and restenosis. This study investigated piperazinedione derived compound TW-01-mediated inhibitory effects on VSMC proliferation and intimal hyperplasia.
Methods: Cell proliferation was determined using [H-3]-thymidine incorporation and MTT assay; cell cycle distribution was measured using flow cytometry; proteins and mRNA expression were determined using western blotting and RT-PCR analyses; DNA binding activity of nuclear factor-kappa B (NF-kappa B), as measured using enzyme linked immunosorbent assays (ELISA); in vivo effects of TW-01 were determined using balloon angioplasty in the rat.
Results: TW-01 significantly inhibited cell proliferation. At the concentrations used, no cytotoxic effects were observed. Three predominant signaling pathways were inhibited by TW-01: (a) extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein kinase (MAPK) activation and its downstream effectors of c-fos, c-jun, and c-myc; (b) DNA binding activity of nuclear factor-kappa B (NF-kappa B); and, (c) Akt/protein kinase B (PKB) and cell cycle progression. Furthermore, TW-01 also inhibited Ras activation, a shared upstream event of each of these signaling cascades. In vascular injury studies, oral administration of TW-01 significantly suppressed intimal hyperplasia induced by balloon angioplasty.
Conclusion: The present study suggests that TW-01 might be a potential candidate for atherosclerosis treatment. (C) 2016 Elsevier Inc. All rights reserved
Data associated with "CO and Dust Properties in the TW Hya Disk From High-Resolution ALMA Observations"
No full textThese are the ALMA TW Hya CO and continuum images and measurement sets published in "CO and Dust Properties in the TW Hya Disk from High-Resolution ALMA Observations.
Data associated with "CO and Dust Properties in the TW Hya Disk From High-Resolution ALMA Observations"
No full textThese are the ALMA TW Hya CO and continuum images and measurement sets published in "CO and Dust Properties in the TW Hya Disk from High-Resolution ALMA Observations.
Development and application of a nested polymerase chain reaction method for the detection of genetically modified soybean in Chinese traditional fermented soy food-sufu.
No full text
TW Hydrae Rotation Maps
No full textA rotation map (line centroids) of CO J = 2-1 emission around TW Hydrae made using the bettermoments package (https://github.com/richteague/bettermoments) including the uncertainties. The original data is available at https://doi.org/10.7910/DVN/PXDKBC (Huang et al. 2018)
TW Hydrae Rotation Maps
No full textA rotation map (line centroids) of CO J = 2-1 emission around TW Hydrae made using the bettermoments package (https://github.com/richteague/bettermoments) including the uncertainties. The original data is available at https://doi.org/10.7910/DVN/PXDKBC (Huang et al. 2018)
Highly efficient laser-driven Compton gamma-ray source
Full text linkThe recent advancement of high-intensity lasers has made all-optical Compton scattering become a promising way to produce ultrashort brilliant gamma-rays in an ultra-compact system. However, so far achieved Compton gamma-ray sources are limited by low conversion efficiency and spectral intensity. Here we present a highly efficient gamma photon emitter obtained by irradiating a high-intensity laser pulse on a miniature plasma device consisting of a plasma lens and a plasma mirror. This concept exploits strong spatiotemporal laser-shaping process and high-charge electron acceleration process in the plasma lens, as well as an efficient nonlinear Compton scattering process enabled by the plasma mirror. Our full three-dimensional particle-in-cell simulations demonstrate that in this novel scheme, brilliant gamma-rays with very high conversion efficiency (higher than 10(-2)) and spectral intensity (similar to 10(9) photons/0.1%BW) can be achieved by employing currently available petawatt-class lasers with intensity of 10(21) W cm(-2). Such efficient and intense gamma-ray sources would find applications in wide-ranging areas. ©2019 The Author(s)
Haemolymph parameters of Pacific white shrimp (Litopenaeus vannamei) infected with Taura syndrome virus.
No full textLight bullets in the spatiotemporal nonlinear Schrodinger equation with a variable negative diffraction coefficient
No full textWe report approximate analytical solutions to the (3+1)-dimensional spatiotemporal nonlinear Schrodinger equation, with the uniform self-focusing nonlinearity and a variable negative radial diffraction coefficient, in the form of three-dimensional solitons. The model may be realized in artificial optical media, such as left-handed materials and photonic crystals, with the anomalous sign of the group-velocity dispersion (GVD). The same setting may be realized through the interplay of the self-defocusing nonlinearity, normal GVD, and positive variable diffraction. The Hartree approximation is utilized to achieve a suitable separation of variables in the model. Then, an inverse procedure is introduced, with the aim to select a suitable profile of the modulated diffraction coefficient supporting desirable soliton solutions (such as dromions, single-and multilayer rings, and multisoliton clusters). The validity of the analytical approximation and stability of the solutions is tested by means of direct simulations
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