58,014 research outputs found
RESTRICTION OF EISENSTEIN SERIES AND STARK-HEEGNER POINTS (Analytic, geometric and -adic aspects of automorphic forms and -functions)
Get PDFThe paper [M.-L. Hsieh and S. Yamana, Restriction of Eisenstein series and Stark-Heegner points, arXiv:2002.11858.] was finished later after the conference. The text of this note has some overlapping with the content in [M.-L. Hsieh and S. Yamana, Restriction of Eisenstein series and Stark-Heegner points, arXiv:2002.11858.].This short note is written based on my talk on a joint work with Shunsuke Yamana [HY20] in the RIMS conference "Analytic, geometric and p-adic aspects of automorphic forms and L-functions" during January 20-24, 2020. The author thanks the organizers for their hospitality during the conference
Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase
No full textSubunit VIIa of mammalian cytochrome c oxidase (COX; EC 1.9.3.1) exists in at least two isoforms, one present in all tissue types ('liver' isoform; COX VIIa-L) and the other specific for cardiac and skeletal muscle (COX VIIa-M). We have isolated a full-length cDNA encoding human COX VIIa-M. The deduced polypeptide represents the human ortholog of COX VIIa-M, as it shares 78% identity with bovine COX VIIa-M, but only 63% identity with human COX VIIa-L. Northern-blot analysis of primate tissues demonstrated that COXVIIa-M mRNA is present only in muscle tissues; in contrast, the COXVIIa-L mRNA is present in both muscle and nonmuscle tissues. Southern-blot hybridization of human-rodent cell hybrid genomic DNA indicates that the COXVHa-M gene maps to a single locus on chromosome 19, designated COX7AM. In contrast, COXVIIa-L cDNA probes hybridized to fragments from two COX7AL loci, on chromosomes 4 and 14. © 1992
Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants
No full textYves S. Y. Hsieh, Brendan L. Wilkinson, Mitchell R. O, Connell, Joel P. Mackay, Jacqueline M. Matthews, and Richard J. Payn
Holocene coastal development in an active arc-continent collision zone of eastern Taiwan
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Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway
No full textLH activates a cascade of signaling events that are propagated throughout the ovarian preovulatory follicle to promote ovulation of a mature egg. Critical to LH-induced ovulation is the induction of epidermal growth factor (EGF)-like growth factors and transactivation of EGF receptor (EGFR) signaling. Because the timing of this transactivation has not been well characterized, we investigated the dynamics of LH regulation of the EGF network in cultured follicles. Preovulatory follicles were cultured with or without recombinant LH and/or specific inhibitors. EGFR and MAPK phosphorylation were examined by immunoprecipitation and Western blot analyses. By semiquantitative RT-PCR, increases in amphiregulin and epiregulin mRNAs were detected 30 min after recombinant LH stimulation of follicles and were maximal after 2 h. LH-induced EGFR phosphorylation also increased after 30 min and reached a maximum at 2 h. EGFR activation precedes oocyte maturation and is cAMP dependent, because forskolin similarly activated EGFR. LH-induced EGFR phosphorylation was sensitive to AG1478, an EGFR kinase inhibitor, and to inhibitors of matrix metalloproteases GM6001 and TNFα protease inhibitor-1 (TAPI-1), suggesting the involvement of EGF-like growth factor shedding. LH- but not amphiregulin-induced oocyte maturation and EGFR phosphorylation were sensitive to protein synthesis inhibition. When granulosa cells were cultured with a combination of neutralizing antibodies against amphiregulin, epiregulin, and betacellulin, EGFR phosphorylation and MAPK activation were inhibited. In cultured follicles, LH-induced MAPK activation was partially inhibited by AG1478 and GM6001, indicating that this pathway is regulated in part by the EGF network but also involves additional pathways. Thus, complex mechanisms are involved in the rapid amplification and propagation of the LH signal within preovulatory follicles and include the early activation of the EGF network. Copyrigh
Molecular cloning and sequence analysis of stearoyl-CoA desaturase in milkfish, Chanos chanos
No full textFatty acid desaturation and stearoyl-CoA desaturase expression in the hepatic microsomes of Milkfish, Chanos chanos, under cold shock
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