2,294 research outputs found
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday
Get PDFAdvances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development
What I know about my ancestors, and their families : also, some account of my wife's ancestors, and their families /
No full textIncludes index."This book is donated by Dr. Victor J. Andrew, great grandson of the author, who copied it from the original manuscript which is in the possession of Mr. Morton O. Perkins, grandson of the author, and who still lives on the author's farm."Reprint of: What I know about my ancestors, and their families : also some account of my wife's ancestors, and their families / Edward Perkins. Weymouth, Ohio : Perkins, 1888.Mode of access: Internet
Measuring and analyzing German and Spanish customer satisfaction of using the iPhone 4S Mobile Cloud service
Get PDFThis paper presents the customer satisfaction analysis for measuring popularity in the Mobile Cloud, which is an emerging area in the Cloud and Big Data Computing. Organizational Sustainability Modeling (OSM) is the proposed method used in this research. The twelve-month of German and Spanish consumer data are used for the analysis to investigate the return and risk status associated with the ratings of customer satisfaction in the iPhone 4S Mobile Cloud services. Results show that there is a decline in the satisfaction ratings in Germany and Spain due to economic downturn and competitions in the market, which support our hypothesis. Key outputs have been explained and they confirm that all analysis and interpretations fulfill the criteria for OSM. The use of statistical and visualization method proposed by OSM can expose unexploited data and allows the stakeholders to understand the status of return and risk of their Cloud strategies easier than the use of other data analysis
Memo from Victor J. Ryan, Asst. Project Director, Heart Mountain, to Division Heads-Section Heads-Timekeepers, June 10, 1944
No full textMemorandum of understanding from Victor Ryan to Division and Section Heads regarding "termination of evacuee workers for cause or disciplinary reasons.The Japanese American Archival Collection documents the people, places, and daily life of Japanese Americans, primarily those who lived in the once thriving community of pre-war Florin in the Sacramento region, as well as the conditions in American incarceration camps during World War II. The approximately 7,000 original items include personal and official letters, photographs, diaries, arts and crafts, newsletters, textiles, camps artifacts, yearbooks and other publications
Rational Approach to the Design of Bioactive Peptidomimetics: Recent Developments in Opioid Agonist Peptides
No full textPharmacological management of severe and chronic pain remains a difficult achievement with currently available analgesic drugs. The design and development of potent opioid analogs with reduced tolerance, dependence, respiratory depression, and other unwanted side effects, could be of great value in the clinical treatment of chronic pain. The hierarchical approach to peptidomimetic design has dramatically advanced over the past three decades; a significant target in research since the discovery of multiple opioid receptors has been to develop highly potent and selective opioid receptor peptidomimetics that overcome the problems related to scarce bioavailability, enzymatic degradation, and low safety profile of natural peptides.
Peptide drug design is a high multidisciplinary area that often relies on the state-of-the-art of organic chemistry, pharmacology, and biochemistry, computational methods and biophysical methods for determining the structural, conformational, topographical, and dynamic properties of designed ligands. With the aim to explore the recent advancements in opioids research, in this chapter, particular attention has been paid on the structural modifications of natural opioid peptides to obtain potent, selective, and stable opioid agonists. In addition, we focused our attention on μ/δ mixed agonists and novel approaches based on multitarget ligands, as discussed in section “Future Perspectives and Conclusions.
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A Norwegian grey zone: Knut Rød, Victor Lind and 'The crucial year, 1942'
No full textThis article uses Primo Levi’s concept of “the grey zone” to explore Knut Rød’s involvement in the transfer of 532 Norwegian Jews from Oslo to Auschwitz in 1942. Rød, the police chief in charge of the operation, was subsequently exonerated of any crime on the grounds that he had simultaneously used his position to help members of Milorg – the Norwegian Resistance. The legal and moral basis of this verdict has been questioned by the artist Victor Lind in a series of artworks, including his “countermonument” The Perpetrator (2005)
Kosciusko [music] /
No full textFor voice and piano.; Cover title.; "Introduced & sung by Miss Nella Webb."; Cover carries portraits of Nella Webb (by Rudolph Buchner), Charles Vaude and Moritz Lutzen.; Words printed as text on p. [4].; "During Moritz Lutzen's visit to Australia he offered a prize for the best lyric, by an Australian author to be set to music by himself. The prize was awarded to Charles Vaude, for his lyric 'Kosciusko,' and Miss Nella Webb produced this song with instantaneous success."--P. [4].; Also available online http://nla.gov.au/nla.mus-an8393500; 1913, by Victor J. Draper, Sydney.; NLA's NL copy from the collection of Keith Watson. ANL
Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors
No full textWe
report the development of macrocyclic melanocortin derivatives
of MT-II and SHU-9119, achieved by modifying the cycle dimension and
incorporating constrained amino acids in ring-closing. This study
culminated in the discovery of novel agonists/antagonists with an
unprecedented activity profile by adding pieces to the puzzle of the
melanocortin receptor selectivity. Finally, the resulting 19- and
20-membered rings represent a suitable frame for the design of further
therapeutic ligands as selective modulators of the melanocortin system
Comparison of renin-specific IgG and antibody fragments in studies of blood pressure regulation
No full text Page H404: Dzau, Victor J., Richard I. Kopelman, A. Clifford Barger, and Edgar Haber. Page H404: Dzau, Victor J., Richard I. Kopelman, A. Clifford Barger, and Edgar Haber. “Comparison of renin-specific IgG and antibody fragments in studies of blood pressure regulation.” The author line should read Dzau, Victor J., Richard I. Kopelman, A. Clifford Barger, Jürg Nussberger, and Edgar Haber. Dr. Nussberger was inadvertently listed in the acknowledgments instead of as an author.Comparison of renin-specific IgG and antibody fragments in studies of blood pressure regulation.” The author line should read Dzau, Victor J., Richard I. Kopelman, A. Clifford Barger, Jürg Nussberger, and Edgar Haber. Dr. Nussberger was inadvertently listed in the acknowledgments instead of as an author. </jats:p
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Structure-activity studies of delta-selective opioid analogues
No full textThe two structurally different peptides DPDPE and Dermenkephalin show a similar remarkably high affinity and selectivity for the delta opioid receptor subtype. An effort has been made to gain some insight into the factors responsible for the recognition ability of these two molecules by synthesizing some DPDPE-Dermenkephalin peptide hybrids and some conformationally restricted Dermenkephalin analogues. The results of the binding and the in-vitro bioassays have been compared with those of the parent peptides. A general decrease in receptor affinity has been observed in the peptide hybrids while the dermenkephalin analogues have shown a wider range of affinities and selectivities. The above findings contribute to the understanding of the structural requirements of the delta receptor, provide information about the sensitivity of Dermenkephalin to enzymatic degradation, and indicate directions for future research
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