2,145 research outputs found
Replication data and online supplement for: "Resilience in Free/Libre/Open Source Software: Do founder decisions impact development activity after crisis events?"
No full textReplication data and online supplement for the Master's thesis, "Resilience in Free/Libre/Open Source Software: Do founder decisions impact development activity after crisis events?" by Wm Salt Hale.
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Data Overview
License
The documentation provided for this project is released under a Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA 4.0) https://creativecommons.org/licenses/by-sa/4.0/.
The code provided for this project is released under the GNU General Public License version 3 (GNU GPLv3) https://www.gnu.org/licenses/gpl-3.0.
The data was collected from the Debian Project. All data provided for this project is released under the GNU General Public License version 3 (GNU GPLv3) https://www.gnu.org/licenses/gpl-3.0 as possible, or the Open Publication License, Draft v1.0 or later (OPLv1+) https://www.debian.org/opl where required. Details on Debian licensing is available on this page: https://www.debian.org/license.
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Wm Salt Hale</a
Letter from Wm. H. Conser, June 25, 1943
No full textTyped correspondence from Wm. H. Conser, President of the Santa Maria Valley Chamber of Commerce, addressed to whom it may concern about Rev. A. A. Heist, Pastor of the Methodist Church. The correspondence discusses the resolutions passed by the Santa Maria Valley Chamber of Commerce.The Bishop James Chamberlain Baker Collection includes letters, documents, and articles about Japanese Americans during World War II. Subjects in the collection include Japanese Americans mass removal, Pearl Harbor and the aftermath, religion, and support from the non-Japanese American community. The collection was digitized and made accessible online by CSUDH Gerth Archives and Special Collections
A Proposal for WM Interprocess Communication
No full textThis report proposes and explores an interprocess synchronization and communication mechanism compatible with the proposed WM protection mechanism -- which is a "capability" based mechanism[Den66]. Despite the advantages of capabilities, early capability systems, including one by the author [Wul80], failed to have a major impact on practical security primarily because of the overhead of domain switching [Col88]. Thus, before committing to a capability mechanism for WM, we want to be sure that we don't make the same mistake again. Thus, this report explores the mechanism in just enough detail to answer whether or not it is practical. Although our main goal is a mechanism for synchronization and communication among protection domains, if possible we would also like a single mechanism that can be used in the place of conventional interrupts, traps, "supervisor calls", entries to protected subsystems, and simple user-to-user interprocess communication. The mechanism we will explore is much-simplified version of the Ada rendezvous [Ada83] in which the WM hardware performs all of the the necessary housekeeping, but software is still able to specify macroscopic policy decisions. At the outset, we stipulate that what we propose may be "too much to put into hardware". But it may not. Our purpose here is to define the mechanism is sufficient detail to be able to meaningfully ask and answer the question "is a hardware implementation practical and desirable"
Lack of association of HLA class I genes and TNF α-308 polymorphism in toluene diisocyanate-induced asthma
No full textBACKGROUND: Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5-15% of the exposed population suggesting an underlying genetic susceptibility. METHODS: To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects. RESULTS: Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects. CONCLUSIONS: These results suggest that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma
Tools of using social media in business-to-business marketing and branding
Get PDFTässä opinnäytetyössä tarjotaan ohjeita yrityksille kuinka he voivat paremmin markkinoida ja brändätä tuotteitansa. Nämä ohjeet koostuvat erilaisten sosiaalisen median alustojen hyödyntämisestä, joista pääasiassa keskitytään Instagramin ja YouTuben hyödyntämiseen toimeksiantajan pyynnöstä.
Tämä opinnäytetyö on tehty WM-Plast Oy:n pyynnöstä ja heidän omistamaa Evermatic -tuotelinjaa ajatellen. WM-Plast Oy on suomalainen yritys, jonka päätoimipiste sijaitsee Suomessa Kankaanpäässä. Tämä työ tehtiin osana oppilasprojektia jossa yritykselle toteutettiin markkinatutkimus vuoden 2019 aikana. Yhtenä markkinatutkimuksen loppupäätelmistä todettiin yrityksen huono näkyvyys sosiaalisen median kanavissa ja yritys ilmaisi halunsa kehittää tätä opinnäytetyön avulla. Tämän työn tarkoitus on siis ohjata WM-Plast tuottamaan parempaa mainontaa tuotteilleen. Tutkimalla näitä markkinointimetodeja, pyritään tarjoamaan tietoa siitä minkälaisia mahdollisuuksia nämä alustat tarjoavat, mitä eri vaihtoehtoja WM-Plast voi hyödyntää harjoittaessaan online-markkinointia, ja mitä tämä voisi tuottaa yritykselle tulevaisuudessa.
Tämän tutkimuksen metodina käytettiin määrällistä tutkimusta. Työ on rakennettu niin että ensimmäiset kappaleet käyvät läpi markkinointi- ja brändäysmahdollisuuksia näiltä sivustoilta. Tämän lisäksi kirjoittaja käy läpi terminologiaa ja eri tavoitteita yrityksen näkökulmasta. Lopuksi tutkimuksen jälkeen kirjoittaja tarjoaa ehdotuksia, kuinka näitä asioita pystyttäisiin hyödyntämään yrityksen nykyisen markkinoinnin osana tai lisänä.In this bachelor thesis, the author will provide an outline for companies on how they can utilize different tools in their efforts when marketing and branding their products in social media. These tools consist of different kinds of social platforms, and the main focus will be set on Instagram and Youtube as requested by the commissioning Company.
The thesis is done based on the request of WM-Plast and their Evermatic line of products. WM-Plast oy is a Finnish company based in Kankaanpää, Finland. The author was part of a project where a group of students provided market research for the commissioning company during the year 2019, and as one of the results from the project noticed that there was a need for the company to improve appearance on social media to provide better promotion for their products. By researching these different marketing methods, the author aims to offer insight on what these kinds of channels are capable of, what different options the company has when applying online marketing, and what this could generate for the commissioning company.
The methodology of this thesis is to first inspect the marketing and branding capabilities of these sites. Explaining the terms in-depth and what the actual targets should be from a business perspective. This is done through quantitative research and will be concluded by giving suggestions on how this can be implemented in the current marketing strategy of WM-Plast Oy
SNP technology and Alzheimer’s disease
No full textOne major goal of genetic research is to understand the role of genetic variation. By far the most common type of such variation in humans involves single DNA bases, and is termed single nucleotide polymorphism (SNP). With sufficient technological solutions, one strong belief is that SNPs can enable the mapping of disease genes involved in complex genetic disorders.Alzheimer’s disease (AD) is a complex disorder characterized by progressive cognitive decline and memory impairment. Some individuals acquire this form of dementia before the age of 65 (referred to as early-onset or familial AD) but most often AD occurs late in life. It is in the early- onset form, however, where causative mutations have been found in three different genes; APP, PSEN1, & PSEN2. Other than these, the only additional risk factor identified for AD is the epsilon 4 allele of the APOE gene. Together these only account for a fraction of AD, leaving room for studies to identify additional AD susceptibility genes.In the initial investigation of this thesis, polymorphisms in the PSEN1, PSEN2, APOE and VLDL-R genes were tested for association with early-onset Alzheimer's disease (EOAD). Aside from confirming the well-established APOE-epsilon4 association, an allele of the PSEN2 showed a significant disease association. In an attempt to verify the PSEN2 association and localize the potential pathogenic variant, a series of eight additional SNPs, located throughout the PSEN2 gene, were tested for association with EOAD. None of the tested markers showed significant disease association upon replication in a second set of cases and controls.The remainder of the thesis describes the invention and development of a novel technique for scoring SNPs. The method, called Dynamic Allele Specific Hybridization (DASH), is a great improvement in both throughput and reliability compared to traditional techniques. The crucial step in the procedure is the heating of the DNA duplex (formed from hybridization of the PCR- amplified target with an allele-specific probe) whilst measuring the fluorescence of a double-strand specific intercalating dye. SNP alleles are detected and scored by comparative analysis of the melting profiles.Improvements to the initial DASH format are detailed in the final two papers of this thesis. A novel alternative in fluorescence detection, termed induced fluorescent resonance energy transfer (iFRET), is introduced. IFRET employs energy transfer between a generic intercalating dye and an FRET acceptor attached to the allele-specific probe. This system retains the spectral-multiplex potential offered by traditional FRET systems, while reducing costs and improving fluorescence signal intensities. Aside from detection, DASH was converted from a microtiter-plate format to an array format which greatly improved flexibility and simplified the assay procedure. The complete DASH-2 system is examined in terms of multiplex options, throughput, cost and accuracy.List of scientific papersI. Brookes AJ, Howell WM, Woodburn K, Johnstone EC, Carothers A (1997). Presenilin-I, presenilin-II, and VLDL-R associations in early onset Alzheimers disease. Lancet. 350(9074): 336-7. https://pubmed.ncbi.nlm.nih.gov/9251642II. Howell WM, Brookes AJ (2002). Evaluation of multiple presenilin 2 SNPs for association with early-onset sporadic Alzheimer disease. Am J Med Genet. 111(2): 157-63. https://pubmed.ncbi.nlm.nih.gov/12210343III. Howell WM, Jobs M, Gyllensten U, Brookes AJ (1999). Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms. Nat Biotechnol. 17(1): 87-8. https://pubmed.ncbi.nlm.nih.gov/9920276IV. Howell WM, Jobs M, Brookes AJ (2002). iFRET: an improved fluorescence system for DNA-melting analysis. Genome Res. 12(9): 1401-7. https://pubmed.ncbi.nlm.nih.gov/12213777V. Jobs M, Howell WM, Stromqvist L, Brookes AJ (2003). DASH-2: Flexible, low-cost and high-throughtput SNP gentyping by Dynamic Allele Specific Hybridization on membrane arrays. [Manuscript]</p
Consistency among WM/GM and between WM and GM matter changes in Group 1.
No full text<p>The correlation matrix among all ROIs, including both GM and WM matter, are given.</p
Spatial Metaphors of Ambiguity in Roman Culture
Get PDFThis is the author accepted manuscript. The final version is available from the Paideia Institute via the link in this recordThis chapter takes a somewhat different approach to the topic of ambiguity in Latin literature from
the others in this volume. Taking as a given that Latin speakers were mindful of the capacity of
some words, phrases, and even whole sentences to convey multiple different meanings, other
chapters examine a range of literary settings where lexical or syntactic ambiguities appear to be
exploited deliberately by Latin authors for imaginative aims. I equally assume an awareness of
ambiguity on the part of Latin speakers, but in this paper I interrogate how they conceived of this
and other types of multiplicity of meaning.1
In other words, I look at how Latin speakers went
about representing ambiguity to themselves and how they understood ambiguity as part of their
experience generally. I start by showing that Latin speakers’ conventional understanding of
ambiguity is delivered metaphorically via the image of PATHS DIVERGING. I also show, however,
that in certain technical contexts the image of CENTRALITY is used, permitting the delineation of
two different kinds of ambiguous meaning relations. I go on to argue that what provides the
motivation for, and thus makes sense of, these twin images is Latin’s regular conceptualization of
“meaning” itself in terms of a linear spatial metaphor. I conclude by suggesting that Latin’s spatial
metaphorics of ambiguity anticipate certain aspects of contemporary linguistic theory – but also
more than this: that it constituted a feature of Roman society’s signifying order, contributing to the
valuation of this phenomenon in the culture
Contradiction of Ideas in George Bernard Shaws Mrs Warrens Profession
Get PDFMrs Warrens Profession categorized as play unpleasant by its author George Bernard Shaw, is
one of world most famous and controversial plays. The play, unlike other play during its era,
uses the corruption and hypocrisy from the upper class of Victorian Era society as the theme.
The play is purposed by the author as a scathing criticism to its theme. This purpose is
materialized on the ideas represented by the two major female characters in the play. Uniquely,
these ideas differs greatly to one on another until it looks like a there is decent contradiction on
it. From this point, this paper aims at finding out ideas represented by the two major female
characters. There are two major female characters being analyzed, Vivie Warren, a Cambridge
graduate and Mrs Warren, both Vivie Warrens estranged mother and a brothel owner. The
finding of the major female characters ideas takes lengthy but worthful steps. The writer first has
to read the script of the play five times. The first and second one are to know the overall of the
drama and take notes of interesting things on the play. When the writer does those two steps
above he also selects the narrations and dialogs in the play are related to the topics and also reads
and analyzes other books and sources related to the topics of the thesis. Those steps above are
essential to gather data that will be used to reveal setting, characters, plot and, theme of the play
in order to do the analysis. He later read the play three more times to group the topics on the
play, categorizes the idea of the major female characters and make sure all ideas are on its
correct place
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