6,094 research outputs found
Howell, Timothy Keith (SC 1144)
No full textFinding aid only for Manuscripts Small Collection 1144. Desert Storm letters (9) written by Timothy Keith Howell to the Snider family of Louisville and a letter from James C. Snider explaining the collection and providing information about Howell and his friends
The role of the epidermal growth factor receptor and its ligands in the regulation of the bronchial epithelial phenotype in smoking related lung disease
No full textCigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD). A common symptom in this condition is that of chronic mucus hypersecretion (CMH), a regular cough productive of sputum. A number of pathological changes are seen in the airways of subjects with COPD and CMH. These changes are provoked by cigarette smoke and recent evidence suggests that the epidermal growth factor receptor (EGFR), which is found in bronchial epithelial cells (BECs), plays a key role in mediating these changes. When activated by smoke, the EGFR promotes release of pro-inflammatory cytokines from BECs and up-regulates mucin gene expression. This is an important mechanism in the process of differentiation of epithelial cells to a mucus secreting goblet cell phenotype. Activation of the EGFR requires cleavage of its ligands by a group of membrane-bound metalloproteinases. In this work it is shown that any of the ligands for the EGFR found in BECs can produce an increase in expression of the pro-inflammatory cytokine interleukin 8 (IL-8) and the secreted mucin MUC5AC. In addition an auto-induction of EGFR ligand expression is seen which may be important in modulating the effects of chronic exposure to noxious stimuli like smoke. The effects of cigarette smoke on release of EGFR ligands with subsequent EGFR activation is confirmed with smoke promoting IL-8 release and increasing expression of both IL-8 and MUC5AC. Doxycycline inhibits the release of EGFR ligands in BECs exposed to smoke. This inhibition reduces the release of IL-8 from the cells and attenuates the mucin gene response. Agents which reduce EGFR ligand shedding from BECs may provide a novel therapeutic target for treatment of CMH in smoking related lung disease.</p
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Jean Sibelius: progressive techniques in the symphonies and tone-poems
No full textAs an analytical and critical survey of Sibelius' symphonies and tone-poems, this study is designed to fill a significant gap in the research of this composer which hitherto has been primarily concerned with historical and musicological issues. Those analytical investigations which exist, typically as a supplement to more biographical concerns, have not made use of modern techniques nor are they comprehensive. Beyond this self-evident purpose of processing analytical findings, the thesis aims not only to demonstrate a symposium of Sibelius' compositional techniques but also to give a new perspective to these achievements.The layout and presentation of material has been designed to facilitate this dual purpose, dispensing with a mere catalogue of analyses in favour of grouping their findings into considerations of larger issues. Thus, Part I - 'The Symphonies' - reflects the layered analytical approach to each work in chapters which move from the general to the particular (Style, Form, Tonality, Thematic Process) selecting examples from the entire genre appropriate to each issue. The final chapter in this section concludes by synthesising those areas in a detailed analysis of a single work. Part II - 'The Tone-Poems' - opens with a more general discussion of the two genres in question revealing cChtrasts and consistencies. Thereafter, their survey divides into two apparently chronological sections, though in fact the distinction is a stylistic one and complements internal considerations of the symphonies themselves.The application of reductive, layered analysis appears to be new in this context and its findings reveal a more progressive compositional attitude than has previously been credited to a figure generally viewed as reactionary. Its evidence, notably in the areas of extended tonality and formal compression, suggests an historical placing for Sibelius within twentieth-century musical developments, indicating both his awareness of the problems facing composers of the period and his personal solutions. The final chapter discusses this essentially speculative topic, its more subjective standpoint balancing the analytical objectivity which constitutes the majority of the thesis. Its conclusion is modest: Sibelius as neither reactionary nor revolutionary, but, nevertheless, progressive
North-south environmentalisms: Friends of the Earth International (FOEI)
No full textBrian Doherty and Timothy Doyl
Money piece by Timothy P. Agnew, chief executive officer of the Finance Author
No full textMoney piece by Timothy P. Agnew, chief executive officer of the Finance Authority of Maine, about the increased availability of credit for Maine\u27s small businesses
Timothy Meyer serves as a contributing author for UN report
No full textAssistant Professor Timothy Meyer served as a contributing author for the United Nations Industrial Development Organization\u27s report titled Networks for Prosperity: Connecting Development Knowledge Beyond 2015. The document, which was released during November, analyzes the nexus between the global connectedness of a country and its economic success, sustainability and government effectiveness. Meyer was one of only approximately 20 academic and practical experts from around the world selected to serve as a contributor after a global call for proposals.
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Selected Contributions of Sister Mary Berenice Beck, O.S.F. to Nursing in the United States, 1923-1956
No full textby Sister M. Timothy Costello.Typescript.Thesis (M.S.N.)--Catholic University of America.Bibliography: leaves 44-47.Also available in microfilm
The Baptismal Liturgy of Theodore of Mopsuestia
No full textTimothy A. Curtin.Typescript.Thesis (S.T.D.)--Catholic University of America, 1971.Bibliography: leaves 368-393
Warwick Smith and Tim Greville (students at Narrabundah College) with Dr Michael Howell (Head of the Department of Zoology)
No full textDepartment of Zoology - Exchanges, Retirements - Dr. Timothy G. Marples, Dr. Peter Janssens, Mr. Ralph Ogden, Ms. Jenny Grigg, Mr. Tony Argyle, Warwick Smith, Tim Greville, Dr. Michael Howell, Kristin Ardlie, Dr. Bill Cowden, Dr. Peter Hunt, Dr. Ian Clark, Brad Imhaff, David Happold & other
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