715 research outputs found
sj-docx-1-mpp-10.1177_23814683231171363 – Supplemental material for Estimating the Cost of 3 Risk Prediction Strategies for Potential Use in the United Kingdom National Breast Screening Program
No full textSupplemental material, sj-docx-1-mpp-10.1177_23814683231171363 for Estimating the Cost of 3 Risk Prediction Strategies for Potential Use in the United Kingdom National Breast Screening Program by Stuart J. Wright, Martin Eden, Helen Ruane, Helen Byers, D. Gareth Evans, Michelle Harvie, Sacha J. Howell, Anthony Howell, David French and Katherine Payne in MDM Policy & Practice</p
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Mock-up example of Cliniface 3D facial ‘Hereditary Angioedema treatment and monitoring report’ Parental consent was obtained from the parent (Gareth Baynam) of the child whose image is appearing in Fig 3 who is also the corresponding author.
No full textMock-up example of Cliniface 3D facial ‘Hereditary Angioedema treatment and monitoring report’ Parental consent was obtained from the parent (Gareth Baynam) of the child whose image is appearing in Fig 3 who is also the corresponding author.</p
Teachers' Toolkit for Supporting Students with Albinism in African Classrooms.
No full textA series of activities and resources developed with partners in Malawi and Zambia as part of the the Albinism in Malawi and Zambia (AIMZ) project at Coventry University. The materials offer teacher educators, teachers, NGO's etc a series of activities and supporting materials to explore the development of good practice in educating students with albinism in inclusive settings
Copper-catalyzed borylative couplings with C−N electrophiles
No full textCopper-catalyzed borylative multicomponent reactions (MCRs) involving olefins and C−N electrophiles are a powerful tool to rapidly build up molecular complexity. The products from these reactions contain multiple functionalities, such as amino, cyano and boronate groups, that are ubiquitous in medicinal and process chemistry programs. Copper-catalyzed MCRs are particularly attractive because they use a relatively abundant and non-toxic catalyst to selectively deliver high-value products from simple feedstocks such as olefins. In this Minireview, we explore this rapidly emerging field and survey the borylative union of allenes, dienes, styrenes and other olefins, with imines, nitriles and related C−N electrophiles.</p
Groups of Automorphisms of Riemann Surfaces and Maps of Genus p+1 Where p is Prime
No full textWe classify compact Riemann surfaces of genus g, where g−1 is a prime p, which have a group of automorphisms of order ρ(g−1)for some integer ρ≥1, and determine isogeny decompositions of the corresponding Jacobian varieties. This extends results of Belolipetzky and the second author for ρ>6, and of the first and third authors for ρ= 3, 4, 5 and 6. As a corollary we classify the orientably regular hypermaps (including maps) of genus p+1, together with the non-orientable regular hypermaps of characteristic −p, with automorphism group of order divisible by the prime p; this extends results of Conder, Širáň and Tucker for maps
Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy
No full textAim In breast cancer patients, post chemotherapy weight gain is linked with increased risk of cancer recurrence. We prospectively studied a cohort of premenopausal women receiving contemporary chemotherapy following a diagnosis of breast cancer to examine factors predicting weight increase. Methods Between May 2005 and January 2008, 523 patients from the Prospective Outcomes in Sporadic versus Hereditary(POSH) cohortcohort entered this sub-study comparing weight prior to chemotherapy and weight and waist/hip measurements 12-months following chemotherapy. Results Data from 380 patients were available. Mean (standard deviation [SD]) pre-treatment body mass index (BMI) was 26.3 [5.6] kg/m2; 30% women gained > 5% body weight during the study period. Lower BMI at diagnosis predicted greater subsequent post treatment weight gain (4.3% relative weight gain for those in the 1st quartile of BMI compared to 0.8% for those in the 4th quartile; r=-0.22; p<0.001). No link to chemotherapy regimens, cigarette smoking, previous parity or chemotherapy induced amenorrhoea was noted. A total of 44% of women had central obesity (post-treatment waist measurement of >88cm). Conclusions Almost a third of premenopausal patients receiving adjuvant chemotherapy for breast cancer will gain clinically significant weight and over 40% will have central obesity 12-months following diagnosis. A greater weight gain is predicted by lower pretreatment BMI
Modular synthesis of stereodefined benzocyclobutene derivatives via sequential Cu- and Pd-catalysis
No full textBenzocyclobutenes (BCBs) are of growing interest in materials and medicinal chemistry, although general routes for their provision remain underexplored. A modular, divergent and stereoselective Cu- and Pd-catalyzed assembly/cyclization sequence allows the synthesis of densely functionalized BCBs, from readily accessible imine, allene and diboron precursors. Preliminary results have identified enantioselective conditions for our protocol, and highlighted, for example, its applicability to the synthesis of BCBcontaining peptides. By simple variation of experimental conditions or substrate modification, our strategy was expanded to deliver indoline and quinoline derivatives, suitable for further manipulations
Edge-transitive embeddings of complete graphs
No full textBuilding on earlier work of Biggs, James, Wilson and the author and on the Graver-Watkins description of the 14 classes of edge-transitive maps, we complete the classification of the edge-transitive embeddings of complete graphs, including those with non-empty boundary.</p
Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic
No full textBACKGROUND: Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including 1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice. METHOD: 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC (n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D (n = 87), or written advice (n = 37). Change in weight and health behaviours were assessed at 12-months.RESULTS: Weight loss at 12 months was -6.3% (-8.2, -4.5) in BCPP, -6.0% (-7.9, -4.2) in MDPP and -3.3% (-6.2, -0.5) in the written group (p = 0.451 across groups). The percentage losing ≥10% weight in these groups were respectively 34%, 23% and 14% (p = 0.038 across groups).DISCUSSION: BCPP and MDPP programmes resulted in more women achieving ≥10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted. Clinical Trial Registration ISRCTN16431108.</p
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