98 research outputs found
Invasive validation of a new oscillometric device (Arteriograph) for measuring augmentation index, central blood pressure and aortic pulse wave velocity
No full textBackground The importance of measuring aortic pulse wave velocity (PWVao), aortic augmentation index (Aix) and central systolic blood pressure (SBPao) has been shown under different clinical conditions; however, information on these parameters is hard to obtain. The aim of this study was to evaluate the accuracy of a new, easily applicable oscillometric device (Arteriograph), determining these parameters simultaneously, against invasive measurements. Methods Aortic Aix, SBPao and PWVao were measured invasively during cardiac catheterization in 16, 55 and 22 cases, respectively, and compared with the values measured by the Arteriograph. Results We found strong correlation between the invasively measured aortic Aix and the oscillometrically measured brachial Aix on either beat-to-beat or mean value per patient basis (r=0.9, P<0.001; r=0.94, P<0.001), which allowed the noninvasive calculation of the aortic Aix without using generalized transfer function. Similarly strong correlation (r=0.95, P<0.001) was found between the invasively measured and the noninvasively calculated central SBPao; furthermore, the BHS assessment of the paired differences fulfilled the 'B' grading. The PWVao values measured invasively and by Arteriograph were 9.41 +/- 1.8 m/s and 9.46 +/- 1.8 m/s, respectively (mean +/- SD); furthermore, the Pearson's correlation was 0.91 (P<0.001). The limits of agreement were 11.4% for aortic Aix and 1.59 m/s for PWVao. Conclusion Aix, SBPao and PWVao, measured oscillometrically, showed strong correlation with the invasively obtained values. The observed limits of agreement are encouragingly low for accepting the method for clinical use. Our results suggest that the PWVao values, measured by Arteriograph, are close to the true aortic PWV, determined invasively. J Hypertens 28: 2068-2075 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
No full textTesticular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,291 SNPs in 986 TGCT cases and 4,946 controls, we selected for follow-up 694 SNPs, which we genotyped in a further 1,064 TGCT cases and 10,082 controls from the UK. We identified SNPs at nine new loci (1q22, 1q24.1, 3p24.3, 4q24, 5q31.1, 8q13.3, 16q12.1, 17q22 and 21q22.3) showing association with TGCT (P < 5 × 10(-8)), which together account for an additional 4-6% of the familial risk of TGCT. The loci include genes plausibly related to TGCT development. PRDM14, at 8q13.3, is essential for early germ cell specification, and DAZL, at 3p24.3, is required for the regulation of germ cell development. Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation
Transparency Vs. Delegitimization? Shrinking Space for Foreign-Funded Organizations in Democracies: Hungary and Israel
No full textIndiana University-Purdue University Indianapolis (IUPUI)The shrinking space for civil society and the increasing number of unfavorable legislation affecting the work of non-governmental organizations continue to be burning issues for global philanthropy. Using a case study approach, this thesis explores how democracies regulate the operation of foreign-funded non-governmental organizations in Hungary and Israel. This thesis examines what the presumed and real motivations of democratic governments are to adapt such regulations and how the political, economic and socio-cultural environments might influence their enactment. This thesis also compares the Hungarian and Israeli regulations to the 1938 Foreign Agents Registration Act
MODELLING AND SIMULATION OF ROCKING SUITCASES
No full textThe rocking motion of two-wheeled suitcases is investigated. A rigid body mechanical model of the suitcase is constructed. All of the possible motion states (both wheels on the ground, one wheel on the ground, none of the wheels on the ground) are taken into account. The switching between the motion states is accomplished by a simple impact model. The motion of the suitcase is investigated through numerical simulations, furthermore the domain of the attraction of the stable rectilinear motion is identified. The model is partly validated by experiments
MODELLING AND SIMULATION OF ROCKING SUITCASES
No full textThe rocking motion of two-wheeled suitcases is investigated. A rigid body mechanical model of the suitcase is constructed. All of the possible motion states (both wheels on the ground, one wheel on the ground, none of the wheels on the ground) are taken into account. The switching between the motion states is accomplished by a simple impact model. The motion of the suitcase is investigated through numerical simulations, furthermore the domain of the attraction of the stable rectilinear motion is identified. The model is partly validated by experiments
The Changing Landscape of U.S. Cross-Border Philanthropy-Analytical Report
No full textThis project has four main goals. First, it expands knowledge on U.S. cross-border philanthropy to promote achievement of the objectives of the U.S. Government (USFS, USAID, and others) and the school. Second, it provides a comprehensive landscape of how funding has changed over time and geography, and identify emerging trends in international partnerships and cross-border philanthropy for U.S. Forest Service partners, United States Agency for International Development/American Schools and Hospitals Abroad (USAID/ASHA) partners, and other organizations that have a similar mission and scope. Third, it identifies the policy levers that positively or negatively influence the capacity and propensity of individuals and organizations to engage in cross-border philanthropic activities. Lastly, it seeks to inform USAID/ASHA partners, practitioners, policymakers, scholars, and the general public of the findings from research projects and offer opportunities for greater discussion about the key topics involved
The Changing Landscape of U.S. Cross-Border Philanthropy-Literature Review
No full textThis project has four main goals. First, it will expand knowledge on U.S. cross-border philanthropy to promote achievement of the objectives of the U.S. Government (USFS, USAID, and others) and the school. Second, it will provide a comprehensive landscape of how funding has changed over time and geography, and identify emerging trends in international partnerships and cross-border philanthropy for US Forest Service partners, United States Agency for International Development/American Schools and Hospitals Abroad (USAID/ASHA) partners, and other organizations that have a similar mission and scope. Third, it will identify the policy levers that positively or negatively influence the capacity and propensity of individuals and organizations to engage in cross-border philanthropic activities. Lastly, it will inform USAID/ASHA partners, practitioners, policymakers, scholars, and the general public of the findings from research projects and offer opportunities for greater discussion about the key topics involved
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