3,280 research outputs found
Carnet de J.D. CHAUPIN
No full textThis 199-page handbook is a monograph on Notre-Dame de Vaulx, a French village located in the Isère département of the Rhône-Alpes region, authored by J.D. CHAUPIN. It was completed in May 1958 and dedicated by the author to his grand-daughter Danielle Marthe CHAUPIN. The first fifty pages contain a glossary of more than 1500 words and the most popular expressions in matheysin patois.The version available here is a second-generation xerox copy of the manuscript collected by Jacqueline DUC, a specialist of matheysin patois.Ce carnet de 199 pages est une monographie sur le village de Notre-Dame de Vaulx, une commune française située dans le département de l'Isère et la région Rhône-Alpes, rédigée par M. J.D. CHAUPIN. Achevé en mai 1958, il est dédicacé à sa petite fille Danielle Marthe CHAUPIN. Il contient sur une cinquantaine de pages un glossaire de plus de 1500 mots ainsi que les expressions les plus courantes en patois matheysin.La version déposée ici est une photocopie de seconde génération du manuscrit réalisée par Jacqueline DUC, spécialiste des patois matheysins
Oral Anticoagulation for hemodialysis patients with atrial fibrillation: the therapeutic conundrum remains
No full textAvailable online: 26 January 2024John D Horowitz, Natasha M Roger
Stress cardiomyopathy: new clinical and pathogenetic insights
No full textJ.D. Horowitz, T.H. Nguyen, C.J. Neil, K. Singh, C. Chong, J. Licari, B. Rama
Geology of Graham Island, British Columbia
No full textby J.D. Mackenzie.Series ; Bulletin (Geological Survey of Canada : 1921). Geological series ; no. 72. Memoir (Geological Survey of Canada) ; 88. Accompanies Southern portion of Graham Island, Queen Charlotte Islands, British Columbia [cartographic material] / geology, J.D. Mackenzie ; geography, British Admiralty and Department of the Naval Service of Canada, Department of Lands, British Columbia, J.D. MacKenzie ; C.O. Senecal, geographer and chief draughtsman. Two folded maps in pocket
Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation.
No full textNitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure
J.D. Manning: The Life of a WWII Draftee
No full textabstract: The biography of J.D. Manning tells the story of the first man drafted in the United States at the dawn of World War II. Growing up, he lived an ordinary, small-town life in Washburn, Wisconsin. However, due to a clerical error, by the time he was inducted into the military, J.D. had assumed a second identity. While listed under a different name throughout his military service, J.D. decided to turn the military into a career. He extended his service and went on to Officer Candidate School before serving in the war. Ultimately, J.D. died in the Battle of Cherbourg. His story outlines the importance of humanizing war at a time when statistics and numbers tend to impersonalize such a large, historical event. J.D.'s biography provides an understanding of how even the most ordinary, typical life of a drafted solider during WWII can produce an extraordinary story. J.D. was not special. He was but one death in a body count of over 400,000 American soldiers during the war. Yet, his story teaches us that one does not have to be special to be important. Every American soldier has made a contribution to our country, yet only a select few have ever had their stories told. This biography of J.D. will add one more story to the limited collection existing today
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
L'usage du narratif dans le Testament de Joseph
No full text(Résumé de l'ouvrage) Seventeen innovative studies are collected in this volume which has been produced under the aegis of the Centre for Biblical Studies, University of Manchester, and L'Institut des sciences bibliques, Université de Lausanne. The majority of the studies engage with narrative through providing insightful working examples. Building on the many contributions of recent narratological research, for the most part the studies in this collection avoid the technical language of narratology as they present fresh insights at many levels. Some essays focus more on the implied author, some on the implied reader or hearer, and some on the way particular messages are constructed; some of the studies consider how author, message and reader are all interconnected. There are several creative proposals for refining genre definition, from law and wisdom to gospel and apocryphal writings. Some studies highlight the way in which narratives can contain ethical, religious, and cultural messages. Sensitivity to narrative is also shown by some contributors to expose in intruing ways the redactional processes behind the final form of texts. Students of narrative in the ancient world will find much to consider in this book, and others engaged with literary studies more generally will discover that scholars of the worlds of the Bible and Late Antiquity have much to offer them
Clopidogrel "resistance": Pre- vs post-receptor determinants
No full textThe clinical efficacy of the P2Y12 receptor antagonist clopidogrel as an agent to prevent thrombotic events predominantly reflects its anti-aggregatory effects. Stent thrombosis in particular is more likely to occur in patients in whom clopidogrel effect is limited.
"Resistance" to clopidogrel in general should theoretically arise either because of a reduction in plasma concentration of the active metabolite and/or of the downstream intracellular biochemical changes underlying antiplatelet effects. We therefore postulate that "resistance" to clopidogrel arises via a combination of pharmacogenetic, pharmacokinetic and intracellular biochemical mechanisms. Considerable attention has been so far directed to the finding that stent thrombosis occurs more frequently in patients with loss-of-function mutations of CYP2C19, thus limiting clopidogrel bioactivation.
Furthermore, a number of drug-drug interactions may marginally impair responsiveness to clopidogrel, largely via impairment of bioactivation. However, population data also suggest that clopidogrel "resistance" occurs more frequently in patients with acute coronary syndromes than in normal subjects, and that "resistance" is particularly common in obese subjects and with diabetes.
Here we critically review available literature and speculate on the possibility that non-genetic causes of clopidogrel "resistance" may arise from impairments of the intracellular signaling cascade initiated by P2Y12 receptor inhibition. In such cases, "resistance" to clopidogrel may also theoretically occur with other P2Y12 receptor antagonists, irrespective of the need for bioactivation. Delineation of this non-genetic component of "resistance" to P2Y12 inhibitors may facilitate the development of optimal therapeutic strategies for high-risk cardiovascular patients.N.L. Hurst, V.B. Nooney, B. Raman, Y.Y. Chirkov, R. De Caterina, J.D. Horowit
Home-based intervention: the next step in treatment of chronic heart failure?
No full textJ.D. Horowit
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