849 research outputs found
Improving the performance of the trolley supply chain with a focus on visibility.
No full textThe lack of visibility, significant investment and a presumption of fleet shrinkage falter the decision-making process of a Dutch airline. Five decision areas have been identified and for each decision area improvements strategies or alternatives have been designed. Selecting the best alternative per decision area is a multi-criteria decision making problem. Therefore, a more sophisticated method is required to support the decision-maker. For this problem the novel Best-Worst Multi-Criteria Decision Making Method (BWM) has been selected. The BWM has been successfully applied to select the best alternative per decision area. Next steps for the airline are the implementation of the chosen alternatives.SEPAMTransport & LogisticsTechnology, Policy and Managemen
Buckfast Abbey Archaeological Projects 1982-2016 Photographic Archive
No full textThis photographic archive is intended to augment the two publications on the abbey's archaeology by S.W. Brown (Proceedings of the Devon Archaeological Society 46, 1988, 13-89; and Devon Archaeological Society Occasional Paper 21, 2018) and the series of more detailed interim archive reports appearing on the ADS website (unpublished grey literature, accessible via author Stewart Brown)
Chapter 3 3D Structure 2. Three Dimensional Structure of Oligosaccharides Explored by NMR and Computer Calculations
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Residual dipolar couplings as new conformational restraints in isotopically 13C-enriched oligosaccharides
No full textAbstractWe report the measurement of residual dipolar couplings for 13C-enriched NeuNAcα2-3Galβ1-4Glc in a dilute liquid-crystalline medium. These couplings provide long-range conformational restraints that hitherto have not been available for oligosaccharides. We utilise these restraints in dynamical simulated annealing calculations, which support current models of the solution behaviour of the trisaccharide
Environment-insensitive two-photon ratiometric probe for in cellulo quantitative measurement of hydrogen peroxide
No full textThe quantitative analysis of a biological analyte directly through fluorescence imaging is essential in biomedical sciences but remains as a challenge owing to the environment-sensitive nature of fluorescence intensity. We show that a fluorescent hydrogen peroxide probe based on an in cellulo super-bright benzothiazolyl-benzocoumarin dye of which emission properties are insensitive to environmental changes offers a reliable and practical means for the quantitative analysis of hydrogen peroxide in cells and tissues directly through ratiometric imaging both under one-photon and two-photon excitation conditions. Different cellular hydrogen peroxide concentrations were determined for several cell lines and also for tumour and normal tissues. © 2021 The Author(s)11Nscopu
Structure and dynamics in oligomannose-type oligosaccharides. Biochemistry
No full textABSTRACT: Using a combination of 'H N M R nuclear Overhauser effect measurements, molecular orbital calculations, and molecular dynamics simulations, we have determined the tertiary structure and dynamic properties of the oligomannose oligosaccharide Mana6(Mana3)Mana6(Mana3)Manp4GlcNAc~4GlcNAc. While the calculated potential surfaces for the majority of the glycosidic linkages could be described by a single deep potential well, similar calculations for the M a n a l d M a n a and Mana 1-6Manp linkages described a diffuse, shallow well, suggesting that a larger degree of flexibility exists about the latter. These conclusions are supported by the results of molecular dynamics simulations, which suggest that the N M R data should be interpreted in terms of a degree of flexibility about the M a n a l d M a n p and Manal-6Mana linkages. In contrast, a similar series of investigations suggests that the conformation of the M a n a l d M a n B linkage in Mana2Man6(Mana2Man~3)Mana6(Mana2Mana2Mana3)Man~4GlcNAc~4GlcNAc is more restricted, resulting in an overall structure that is "restrained". High-resolution *H nuclear magnetic resonance is a well-established method for the derivation of the three-dimensional structures of biomolecules in solution. The use of two-di-mensional coherence-transfer methods such as 'H-lH corre
Molecular simulation of porous silica and B-alumina, using a scalable method for electrostatic interactions
No full textApplied Science
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