105,584 research outputs found
Paul Hofer. Die Kunstdenkmäler des Kantons Bern ; t. III : Die Staatsbauten der Stadt Bern, 1947
No full textAubert Marcel. Paul Hofer. Die Kunstdenkmäler des Kantons Bern ; t. III : Die Staatsbauten der Stadt Bern, 1947. In: Bulletin Monumental, tome 106, année 1948. pp. 237-238
E. & T. Hofer, Proper Peasants. Traditional Life in a Hungarian Village
No full textKarnoouh Claude. E. & T. Hofer, Proper Peasants. Traditional Life in a Hungarian Village. In: L'Homme, 1975, tome 15 n°3-4. Du mariage et de l'inceste. pp. 225-228
Heat Transfer and Film Cooling of Blade Tips and Endwalls
No full textThis paper investigates the flow, heat transfer, and film cooling effectiveness of advanced high pressure turbine blade tips and endwalls. Two blade tip configurations have been studied, including a full rim squealer and a partial squealer with leading edge and trailing edge cutouts. Both blade tip configurations have pressure side film cooling and cooling air extraction through dust holes, which are positioned along the airfoil camber line on the tip cavity floor. The investigated clearance gap and the blade tip geometry are typical of that commonly found in the high pressure turbine blades of heavy-duty gas turbines. Numerical studies and experimental investigations in a linear cascade have been conducted at a blade exit isentropic Mach number of 0.8 and a Reynolds number of 9×105. The influence of the coolant flow ejected from the tip dust holes and the tip pressure side film holes has also been investigated. Both the numerical and experimental results showed that there is a complex aerothermal interaction within the tip cavity and along the endwall. This was evident for both tip configurations. Although the global heat transfer and film cooling characteristics of both blade tip configurations were similar, there were distinct local differences. The partial squealer exhibited higher local film cooling effectiveness at the trailing edge but also low values at the leading edge. For both tip configurations, the highest heat transfer coefficients were located on the suction side rim within the midchord region. However, on the endwall, the highest heat transfer rates were located close to the pressure side rim and along most of the blade chord. Additionally, the numerical results also showed that the coolant ejected from the blade tip dust holes partially impinges onto the endwall.</jats:p
Mythos Andreas Hofer
No full textBetrachtet man den Lebenslauf des Volkshelden Andreas Hofer in der Literatur, findet man in vielen Büchern und Lebensläufen idealisierte Darstellungen seiner Person. Man findet Parallelen zu Jesus Christus, sowie idealisiertes Heldentum des Tirolers. Zahlreiche Autoren versuchen ihre Leser zu polarisieren und rückten den Sandwirt in den jeweiligen historischen Blickwinkel, der der jeweiligen Zeit dienlich war. Die Arbeit zeigt, dass das Haus Habsburg, für das Hofer treu ergeben kämpfte, diesen erst gut 80 Jahre nach dessen Tod in eigener Sache zu schätzen begann, da er zweckdienlich als Werbeträger eingesetzt wurde.
Über den Zeitraum von 200 Jahren wird Andreas Hofer auf unterschiedlichste Form gedacht- sei es mit Denkmälern, Gebäuden, Plätzen, Strassen, Gassen, Schokolade, Bier, T-Shirts, Filmen, Theaterstücken oder Gedenkmünzen. Sein Mythos wird überliefert und am Leben erhalten.
Diese Arbeit schildert einen ausführlichen Lebenslauf Hofers, sowie dessen Mythologisierung. Sie berichtet, wie sich das Bild des Freiheitskämpfers über die Jahre verändert hat, schildert die großen Gedenkfeieren und widmet sich der Rezeption zur Person. All diese Schilderungen können allerdings nur Tatsachen und Fakten aufzählen, geschichtliche Ereignisse, wie Literaturhinweise verdeutlichen, Zusammenhänge herstellen und erklären, durch welche Zusammenhänge und Mittel eine Mythologisierung statt fand
Hofer (Paul). Die Kunstdenkmäler des Kantons Bern ; t. II : Die Stadt Bern (Gescllschafthäuser und Wohnbauten) (Die Kunstdenkmäler der Schweiz)
No full textAubert Marcel. Hofer (Paul). Die Kunstdenkmäler des Kantons Bern ; t. II : Die Stadt Bern (Gescllschafthäuser und Wohnbauten) (Die Kunstdenkmäler der Schweiz). In: Bulletin Monumental, tome 118, n°1, année 1960. p. 86
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
FOLCOM or the costs of tagging
No full textThis paper introduces FOLCOM, a FOLksonomy Cost estimatiOn Method that uses a story-points-approach to quantitatively assess the efforts that are cumulatively associated with tagging a collection of information objects by a community of users. The method was evaluated through individual, face-to-face structured interviews with eight knowledge management experts from several large ICT enterprises interested in either adopting tagging internally as a knowledge management solution, or just in tangible evidence of its added value. As a second theme of our evaluation, we calibrated the parameters of the method based on data collected from a series of six user experiments, reaching a promising prediction accuracy within a margin of ±25% in 75% of the cases
Hofer (Paul). Die Kunstdenkmäler des Kantons Bern. T. I : Die Statd Bern (Die Kunstdenkmäler der Schweiz) ; Dejung (Emanuel), Zürcher (Richard) et Hoffmann (Hans). Die Kunstdenkmäler des Kantons Zürich. T. VI : Die Stadt Wintherthur, die Statd Zurich (Die Kunstdenkmäler der Schweiz)
No full textAubert Marcel. Hofer (Paul). Die Kunstdenkmäler des Kantons Bern. T. I : Die Statd Bern (Die Kunstdenkmäler der Schweiz) ; Dejung (Emanuel), Zürcher (Richard) et Hoffmann (Hans). Die Kunstdenkmäler des Kantons Zürich. T. VI : Die Stadt Wintherthur, die Statd Zurich (Die Kunstdenkmäler der Schweiz). In: Bulletin Monumental, tome 111, n°1, année 1953. pp. 96-97
Method development for analysis of 8-oxodG as a biomarker for oxidative stress
No full textOxidative damage to DNA gives oxidation of DNA bases and strand breaks that can cause mutations leading to cancer. Various forms of agents are capable of oxidising DNA in vivo including peroxides, singlet oxygen and UV- or gamma-irradiation. Oxidation of DNA bases occurs mainly at dG, giving stable DNA adducts such as 8-oxodG and FapydG.The use of 8-oxodG as a biomarker (expressed as the ratio 8-oxodG/dG) requires well- controlled workup conditions because 8-oxodG can be formed during the workup procedure. This may result in false high levels with difficulties in determining the true background levels, and differences between control and exposed tissue as a result. Existing methods require time consuming and warm (37°C) workup steps to extract and hydrolyse DNA before analysis. Since natural levels of 8-oxodG are low, a sensitive analytical tool is required when working with low mg amounts of cells.In this thesis, methods for workup procedures and analysis of 8-oxodG in DNA using HPLC/EC/UV and 32P-HPLC were developed. 32p was found to strongly oxidise dG into 8- oxodG and a HPLC pre-separation step was developed before 32p- postlabelling of 8-oxodG. Factors such as the purity of solutions, temperature, incubation time, peroxide removal and amount of cells during the sensitive workup procedure were found important, affecting the 8- oxodG/dG ratio. A fast (=10 min) cold (0°C), high salt non-phenol DNA extraction method procedure was developed to reduce the artifactual 8-oxodG formation. In addition, the use of catalase and the electron acceptor TEMPO was found to be protective against artifactual oxidation.A new hydroxylation mechanism of carbon compounds by peroxides is suggested, where transition metals mediate the two-electron reduction of H202, with one-electron oxidation of the reducing agent and compound respectively. This produces carbon radical cations, which are hydroxylated in water. For dG oxidation in a H202ascorbate system, this mechanism is shown to be thermodynamically favourable to a one-electron reduction of H202, producing OH° and, in addition, added OH° scavengers were found to be ineffective. Peroxide oxidation of DNA is likely, if forming DNA radical cations, to give mainly oxidation of G due to electron transfer in DNA, compared to systems generating the more randomly adding OH° (such as gamma- radiolysis of water).Background 8-oxodG/dG ratios in human lymphocytes were found to be much lower than previously reported. Oxidation of dG to 8-oxodG during workup was found to be relatively constant and to fit a mathematically defined curve that can help in estimating the true background level and the artifactual formation of 8-oxodG.As the degree of workup formation of 8-oxodG can vary on different days, it is important to include control samples during each round of workup and analysis.List of scientific papersI. Moller L, Hofer T (1997). "[32P]ATP mediates formation of 8-hydroxy-2-deoxyguanosine from 2-deoxyguanosine, a possible problem in the 32P-postlabeling assay. " Carcinogenesis 18(12): 2415-9 https://pubmed.ncbi.nlm.nih.gov/9450489II. Hofer T, Moller L (1998). "Reduction of oxidation during the preparation of DNA and analysis of 8-hydroxy-2-deoxyguanosine. " Chem Res Toxicol 11(8): 882-7 https://pubmed.ncbi.nlm.nih.gov/9705749III. Moller L, Hofer T, Zeisig M (1998). "Methodological considerations and factors affecting 8-hydroxy-2-deoxyguanosine analysis. " Free Radic Res 29(6): 511-24 https://pubmed.ncbi.nlm.nih.gov/10098456IV. Zeisig M, Hofer T, Cadet J, Moller L (1999). "32P-postlabeling high-performance liquid chromatography (32P-HPLC) adapted for analysis of 8-hydroxy-2-deoxyguanosine. " Carcinogenesis 20(7): 1241-5 https://pubmed.ncbi.nlm.nih.gov/10383896V. Hofer T (2000). "Oxidation of 2-deoxyguanosine by H202-ascorbate: evidence against free OH and thermodynamic support for two-electron reduction of H2O2." J Chem Soc, Perkin Trans 2: 210-3VI. Hofer T, Moller L (2001). "Optimization of the workup procedure for the analysis of 8-oxo-7, 8-dihydro-2-deoxyguanosine with electrochemical detection." (Submitted)</p
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