1,754 research outputs found

    De boven- en ondergrond van de stad als een samenhangend systeem: The surface and subsurface of the city as a united system

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    No healthy city without a healthy surface. And yet the soil and its associated eco- and water system are a final piece in area development practice. What if we were to draw cross-sections through the above- and underground city more often and pay more attention to the 'technical space' of nature and the city below ground level? Can we achieve a more sustainable design of urban space with this?Accepted Author ManuscriptEnvironmental Technology and DesignPractice Chair Urban Area Developmen

    Author inscription in Poems

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    This edition includes an author's inscription, "with the regards of J.T. Fields."Fields, James Thomas, 1817-1881

    Design studio performance in complex spatial projects: lessons from The Netherlands

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    The Netherlands has a strong design tradition in planning for the built environment. After a period of neglect, attention for the role of design studios has resurged, particularly for addressing complex spatial projects. These area-based projects have impacts that cut across local to regional scales, so setting up a design process that addresses these scales and engages a wide range of relevant parties proves helpful for formulating design briefs and identifying potential spatial outcomes. This paper discusses the role of the design studio in the Dutch practice, exploring to what extent it helps in identifying the integrated outcomes desired

    Measuring industry-science links through inventor-author relations: A profiling method

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    In this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;

    Implementation of a microclimate design model in the early design of new building projects: Case study Ecohof Noorderveer in the Netherlands

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    Given the ongoing global urbanization and the rise of heat, flooding, and drought in cities, the integration of climate adaptive measures based on “ecosystem functions and services” becomes imperative in design. This study details the implementation process of a microclimate design model in the design and retrofitting of the housing project Ecohof Noorderveer in Wormerveer, the Netherlands. The model, which quantifies local urban heat and mitigating measures through ecosystem functionalities, was incorporated into the program of requirements. The design process followed a research-by-design trajectory, involving iterative creative collaboration among all stakeholders, including future residents, the municipality, the water board, and the architect. The research employed the CFIR method to compare anticipated implementation outcomes with actual results. The findings suggest that introducing the microclimate design model into the program of requirements proved beneficial for the implementation process in the early design stage. The research-by-design approach was also deemed helpful, contingent on careful involvement of all participants in the knowledge-sharing process. This implementation method demonstrates significant potential for scaling up to standard urban development projects.Materials and EnvironmentPractice Chair Urban Area DevelopmentMaterials- Mechanics- Management & Desig

    Reverse engineering of industrially relevant phenotypes in yeast: An integrated approach

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    Reverse engineering is the study of discovering the structure, function and operation of a device or system with the express aim to reconstruct its key functionalities. This principle is applied to many disciplines, from military, through computer engineering, to health, but also in metabolic engineering. In this context, reverse metabolic engineering examines a particular functionality or phenotype of a cell or culture and subsequently aims to reconstruct it, with the aid of targeted genetic modification, in another cell or culture. Even with increasing knowledge on targeted metabolic engineering, microbial production platforms for fuels and chemicals are often obtained by non-targeted approaches, such as mutagenesis or evolutionary engineering. Reverse engineering of the interesting traits of these microbial platforms not only provides the potential to implement and combine them in other hosts, but also allows for the protection of the resulting intellectual property. The major challenge in reverse metabolic engineering is the elucidation of the molecular mechanisms underlying the phenotype of the strains of interest. In this thesis, various techniques were evaluated for their application in reverse metabolic engineering of a diverse range of industrially relevant phenotypes in the yeast Saccharomyces cerevisiae. Simultaneously, the different analytical methods that were used in these studies were evaluated for their individual and combined contributions.BiotechnologyApplied Science

    Time-lapse seismic monitoring of subsurface stress dynamics

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    Civil Engineering and Geoscience
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