159 research outputs found
Ceプニクタイトの異常磁性とP-f混成機構についての実験的研究(VI. Ce化合物系,価数揺動状態の総合的研究,科研費研究会報告)
No full textこの論文は国立情報学研究所の電子図書館事業により電子化されました
Effects of modulatory agents on neurally-mediated responses of trout intestinal smooth muscle in vitro
No full textMediators and mechanisms responsible for the inhibitory modulation of trout intestinal smooth muscle were examined using a series of putative mediators and substances known to modulate neurotransmission in mammalian systems. Frequency response relationships to transmural stimulation and concentration response relationships to 5-hydroxytryptamine, carbachol, and substance P were established on paired segments of rainbow trout intestine in vitro in the presence and absence of putative modulatory agents. Modulation of neurally-mediated contractions of trout intestine was achieved with dibutyryl cyclic AMP and forskolin, agents that increase intracellular levels of cyclic AMP. The effect appears to be at the level of the smooth muscle, since the adenylate cyclase activator, forskolin, inhibited muscarinic and serotoninergic contractions as well as transmurally stimulated contractions. Substance P-induced contractions were unaffected by forskolin. The endogenous agonists/neurotransmitters which would increase cyclic AMP levels in rainbow trout intestinal smooth muscle are as yet unknown. The effects do not appear to be modulated by vasoactive intestinal peptide (VIP), calcitonin, calcitonin gene-related peptide (CGRP), or agents that activate beta-adrenoceptors. Prostaglandin E(2) (PGE(2)) and alpha(2)-adrenergic agonists are possible agents which will decrease contractility of the smooth muscle. They were only active in the proximal intestine and on transmurally stimulated contractions. The effects of both PGE(2) and alpha(2)-agonists appear to be prejunctional, decreasing release of contractile neurotransmitters in the enteric nervous system.PT: J; CR: AHRENS RC, 1984, PHARMACOTHERAPY, V4, P105 ALDMAN G, 1992, GEN COMP ENDOCR, V88, P287 BAUER V, 1982, BRIT J PHARMACOL, V76, P569 BRINK C, 1981, J PHARMACOL EXP THER, V217, P592 BURKA JF, 1983, J PHARMACOL EXP THER, V225, P427 BURKA JF, 1989, CAN J PHYSIOL PHARM, V67, P477 BURKA JF, 1992, AQUACULTURE, V100, P321 BURNSTOCK G, 1958, BRIT J PHARMACOL CHE, V13, P216 BURNSTOCK G, 1959, Q J MICROSC SCI, V100, P199 CARPENTER JR, 1986, J PHARMACOL METHOD, V15, P283 COLEMAN RA, 1994, PHARMACOL REV, V46, P205 DARNELL J, 1990, MOL CELL BIOL DOCKRAY GJ, 1988, ISI ATLAS-PHARMACOL, P40 DREW GM, 1978, BRIT J PHARMACOL, V64, P293 FOUCHEREAUPERON M, 1990, BIOCHEM BIOPH RES CO, V172, P582 FOUCHEREAUPERON M, 1994, NEUROPEPTIDES, V26, P267 FURNESS JB, 1980, NEUROSCIENCE, V5, P1 GROVE DJ, 1992, J EXP BIOL, V163, P33 HAZEL JR, 1992, J COMP PHYSIOL B, V162, P593 HILLS JM, 1983, EUR J PHARMACOL, V88, P371 HOLMGREN S, 1982, CELL TISSUE RES, V223, P141 HOLMGREN S, 1983, COMP BIOCHEM PHYS C, V74, P229 HOLMGREN S, 1985, NEUROSCIENCE, V14, P683 JENSEN J, 1991, GEN COMP ENDOCR, V83, P388 KANEKO T, 1989, FISH PHYSIOL BIOCHEM, V7, P337 KITAZAWA T, 1986, BRIT J PHARMACOL, V89, P259 KITAZAWA T, 1988, COMP BIOCH PHYSL C, V91, P585 KITAZAWA T, 1989, BRIT J PHARMACOL, V98, P781 KITCHEN I, 1984, TXB IN VITRO PRACTIC LABURTHE M, 1981, ADV PHYSL SCI, V12, P175 LEFKOWITZ RJ, 1990, GOODMAN GILMANS PHAR, P84 MARTIAL K, 1994, P NATL ACAD SCI USA, V91, P4912 NILSSON S, 1984, MAR BIOL LETT, V5, P127 NILSSON S, 1993, PHYSL FISHES, P279 OHTANI R, 1989, CELL TISSUE RES, V258, P35 REID SD, 1991, J EXP BIOL, V158, P199 RUFFOLO RR, 1994, PHARMACOL THERAPEUT, V61, P1 SEAMON KB, 1981, P NATL ACAD SCI USA, V78, P3363 TIMMERMANS PBM, 1981, J AUTON PHARMACOL, V1, P171 UNDERHAY J, 1994, B AQUACUL ASS CANADA, V942, P42 WATSON S, 1995, TRENDS PHARM SCI S, V16, P10 WEISS B, 1977, ADV PHARMACOL CHEMOT, V14, P189; NR: 42; TC: 4; J9: FISH PHYSIOL BIOCHEM; PG: 10; GA: UN243Source type: Electronic(1
Nutrition, Immunity and Viral Infections
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Nutrition, Immunity and Viral Infections
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
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