91 research outputs found
Emerging Role of Eruca sativa Mill. in Male Reproductive Health
No full textA growing interest has been drawn to the use of traditional medicinal plants for the treatment of human diseases and, in particular, infertility and reproductive toxicity associated with environmental factors. The Mediterranean basin area is a recognized source of plant species with therapeutic interest. In this frame, Eruca sativa (ES) is an annual edible plant and a member of the Brassicaceae family. A relatively large number of studies, focusing on the biological effects of the extract from the leaves of ES on in vitro and in vivo models of disease, have been published in recent years. The present narrative review aims to analyze the phytochemical constituents, traditional uses, possible pharmacological activities, and recognized effects of ES on male reproductive outcomes. Available investigations have revealed the presence of a number of compounds with antioxidant properties, such as polyphenols, glucosinolates, flavonoids, and carotenoids in extracts from ES. Based on the chemical and pharmacological characteristics of the aforementioned compounds, we show that ES has possible preventive properties and therapeutic uses, especially in the functional derangements of the male reproductive system
Synergistic healing: harnessing snail mucus enriched with carob extract for anti‐inflammatory and antioxidant therapy in ulcerative colitis
No full textBackground: Inflammatory bowel diseases (IBD), including ulcerative colitis, are characterized by chronic inflammation and oxidative stress, necessitating novel therapeutic approaches. This study explores the therapeutic potential of snail mucus derived from snails fed different concentrations of carob (SSCS) and compares its efficacy to aqueous carob extracts (AECS). Both SSCS and AECS are rich in bioactive compounds with potential anti-inflammatory, antioxidant and tissue-regenerative effects. Results: Snail mucus was found to be rich in collagen and allantoin, which are crucial for tissue repair and cell regeneration, whereas carob extracts contained high levels of phenolics, tannins and flavonoids, contributing to their antioxidant properties. In a rat model of acetic acid-induced ulcerative colitis, pretreatment with SSCS, AECS or sulfasalazine significantly alleviated colonic damage. The SSCS30% group exhibited the strongest protective effects, comparable to sulfasalazine, in reducing mucosal injury, inflammation and immune activation. Biochemical analyses demonstrated that SSCS30% effectively decreased systemic inflammation markers (CRP), pancreatic stress indicators (amylase) and liver enzyme levels (AST, ALT, ALP), while enhancing antioxidant defenses and preserving colonic sulfhydryl content. Conclusion: These findings underscore the therapeutic potential of snail mucus, particularly from snails fed a 30% carob-enriched diet, as a promising natural therapy for IBD. Its potent anti-inflammatory, antioxidant and tissue-regenerative properties suggest that the use of SSCS30% could serve as an innovative approach for managing ulcerative colitis and other inflammatory disorders. These findings suggest that carob-enriched snail mucus could serve as a complementary therapy for ulcerative colitis patients, though clinical validation remains necessary. While these preclinical results are promising, further clinical studies are needed to validate the therapeutic potential of this natural combination in human ulcerative colitis. © 2025 Society of Chemical Industry
Protective effect of essential oil of Foeniculum vulgare Mill. against bleomycin-induced pulmonary fibrosis and oxidative stress in rat
No full textBackground: Wild fennel (Foeniculum vulgare Mill.) is a very common plant used in traditional medicine to treat
several diseases. In recent years, scientific research proved its biological properties. However, the protective
effect of fennel against bleomycin-induced pulmonary fibrosis (BLM-IPF) is not yet study.
Purpose: Fennel essential oil (FEO) composition was characterized and its protective effect was assessed.
Methods: GC–MS was employed to determine the chemical composition of fennel essential oil. The antioxidant
activity was evaluated using TAC, DPPH, RAP and ABTS assays. After inducing fibrosis by bleomycin, several
biological assays were used to evaluate the protective effect [proteins content, malondialdehyde MD, thiol group,
superoxide dismutase (SOD) and catalase (CAT)].
Results: FEO was rich in estragole (77.55 %), fenchone (9.23 %), and limonene (9.23 %), and phenolic compounds
and showed a significant antioxidant potential. The effects on BLM-IPF were revealed by disruption and
alteration of oxidative stress biomarkers in lung, liver and kidney. Treatment of rats with FEO improved
abnormal fluctuations in protein and thiol levels, decreased oxidative stress in terms of MDA and also restored
the response of the antioxidant system, measured in terms of SOD and CAT, in lung, liver and kidney. The
biological activity was recorded in a dose response manner. The potential of FEO in limiting the progress of the
histopathologic effects of BLM-IPF was confirmed by microscopic histological observations, with a reduction of
the fibrosis score and the inflammatory index in the FEO treated lung tissue.
Conclusion: These results, proved that FEO could attenuate BLM-induced PF, thus suggesting that the latter could
serve as a potential therapeutic approach for PF
Aqueous extract of Eruca Sativa protects human spermatozoa from mitochondrial failure due to bisphenol A exposure
No full textYoussef al-Sebai as a novelist
No full textBu çalışmada, 20. yüzyıl Mısır edebiyatının önemli kısa hikâye ve roman yazarlarından biri olan Yusuf es-Sibâ'î'nin hayatı, edebî kişiliği ve romanları incelenmektedir. Sibâ'î'nin yaşadığı dönem; sosyal, siyasi ve kültürel açıdan önemli pek çok olaya şahitlik etmiştir. Bu olaylar arasında, 1919 ve 1952 devrimleri, Arap-İsrail savaşı, Mısır'ın öncülük ettiği Arap birliğinin kuruluşu, kadınların bireysel ve toplumsal hak ve özgürlüklere kavuşması gibi önemli gelişmeler yer almaktadır. Bu olaylara kayıtsız kalmayan Sibâ'î, romanları aracılığıyla Mısır'ın siyasi hayatını, bağımsızlık mücadelesini ve bu süreçte yaşanan önemli gelişmeleri kurgusal aleme taşımıştır. Bu durum yazarın romanlarının, sosyal, siyasi ve kültürel anlamda zengin bir içeriğe sahip olmasını sağlamıştır. Sibâ'î'nin fantastik, gerçekçi, romantik ve psikolojik türden kaleme aldığı romanlarında ağırlıklı olarak romantik bir eğilim kendini gösteriyor olsa da romantizmi ve realizmi aynı çatı altında başarılı bir şekilde birleştirdiği görülmektedir. Bu sayede, romanlarında gerçekçi ve romantik unsurları harmanlamış ve okuyucuya etkileyici bir okuma deneyimi sunmuştur. Ayrıca Sibâ'î'nin eserleri, Mısır edebiyatında bir dönüm noktası olarak kabul edilmektedir. Bu eserler, dönemin siyasi ve toplumsal sorunlarına dair kayda değer birer belge niteliği taşımaktadır. Bu yönüyle de yazarın eserleri Mısır edebiyatının önemli bir parçasıdır ve gelecek kuşaklara aktarılması gereken bir miras olarak değerlendirilmelidir.This work focuses on the life and literary works of Youssef al-Sebai, one of the leading short story and novel writers of 20th century Egyptian literature. The period in which the author lived witnessed many important events from political, social, and cultural perspectives. Among these events were the 1919 and 1952 revolutions, the Arab-Israeli war, the establishment of the Arab unity led by Egypt, and the achievement of individual and societal rights for women. Youssef al-Sebai did not remain indifferent to these events and addressed the significant developments that occurred during Egypt's political life and struggle for independence through his works. His works demonstrate that they have a rich content in terms of social, political, and cultural meanings. Youssef al-Sebai used fantastic, realistic, romantic and psychological genres in his works. Although a romantic tendency is mainly observed in his novels, the author successfully combined romanticism and realism under the same roof. In this way, he blended realistic and romantic elements in his works and provided readers with an impressive reading experience. Furthermore, Youssef al-Sebai's works are considered a turning point in Egyptian literature. These works are regarded as important documents on the political and societal issues of their time. In this sense, the author's works are an important part of Egyptian literature and should be recognized as a legacy that needs to be passed down to future generations
Protective action of Eruca sativa leaves aqueous extracts against Bisphenol A-caused in vivo testicular damages
No full textGlobularia alypum L. Modulates Inflammatory Markers in Human Colon and Shows a Potential Antioxidant Role in Myeloid Leukemic Cells
No full textGlobularia alypum (GA), a plant of the Globulariacea family, has long been used as a traditional cure for inflammatory and metabolic illnesses. In addition to various in vitro model studies, the current work focuses on the antioxidant and anti-inflammatory properties of GA in human colon biopsies. The phenol components in GA aqueous extract (GAAE) were identified by Liquid Chromatography-Electrospray Ionization Mass Spectrometry. The antioxidant ability of GAAE was tested in vitro utilizing chemiluminescence and flow cytometry using fluorescent yeasts n conjunction with PLB-985-human myeloid leukemia cells. Experiments on human colon biopsies after a biopsy challenge with Escherichia coli-lipopolysaccharides aimed to see if GAAE had an anti-inflammatory impact on human colon inflammation. Western blotting was used to assess the expression of several inflammatory markers. According to the findings, GAAE had a significant influence on hydrogen peroxide and cellular reactive oxygen species. GAAE inhibited the activities of cyclooxygenase 2 and nuclear factor B in inflamed biopsies, indicating anti-inflammatory action. The present study is the first to show that GA has a beneficial effect on human colon inflammation, thanks to its significant antioxidant activity in vitro. According to these preliminary data, GA may be utilized to treat a range of human inflammatory illnesses
The Role of Increased Gastric Acid Secretion and Reactive Oxygen Species in the Pathophysiology of Reflux Esophagitis
No full textBiorefining of microalgae to prepare novel high added value ingredients
No full textLe bioraffinage des microalgues apportent très souvent une valeur ajoutée. La microalgue Tetraselmis chuii est une source prometteuse d’une variété de biomolécules potentiellement valorisable. Cependant, l’extraction et la récupération de ces composés avec une meilleure qualité reste un défi technologique en raison des problèmes inhérents liés à leur disponibilité et leur stabilité. Dans le cadre de ce travail de thèse, les composés hydrosolubles notamment les protéines de T. chuii ont été extraites soit à une traitement soit par extrusion, soit par macération. Leur récupération a été réalisée par filtration membranaire. La première partie de cette thèse consiste à optimiser par plan d’expériences des deux procédés appliquées pour l’extraction des protéines hydrosolubles à partir des microalgues lyophilisées. Un rendement d’extraction maximal de protéines (78,38%) a été obtenu dans les conditions optimales de macération suivantes : Une concentration en biomasse lyophilisé de 7,5 g.L-1, une température de 20°C et un pH égale à 12, avec 2 heures d’extraction. Dans les conditions d'extrusion optimisées, le rendement protéique maximal a atteint 25,02 % pour une vitesse de rotation de la vis de 400 tr/min, une température de 25°C et un débit de 1 kg.h-1aprés quelques minutes d’extraction. Ainsi un couplage entre macération/extrusion, pour avoir un rendement protéique un peu plus élevé de 27,10% après 5h d’extraction. La deuxième partie s’est focalisée sur la récupération après macération, par filtration sur des membranes ayant différents seuils de coupure, des protéines solubles. La filtration avec toutes les membranes est quasi-similaire pour concentrer les protéines avec une pureté entre 13-16%. La filtration sur une membrane de 300 kDa a montré une augmentation de récupération de 67% des protéines dans le retentât comparativement à la filtration sur 3 kDa, 15 kDa, 50 kDa et 150 kDa. Ainsi la sélectivité est toujours inférieure à 1 pour toutes les membranes.Biorefining microalgae often provides added value. The microalga Tetraselmis chuii is a promising source of a variety of potentially valuable biomolecules. However, extracting and recovering these compounds with improved quality remains a technological challenge due to the inherent problems associated with their availability and stability. In this thesis, water-soluble compounds, in particular T. chuii proteins, were extracted either by treatment, extrusion or maceration. They were recovered by membrane filtration. The first part of this thesis consists of optimising the two processes applied for the extraction of water-soluble proteins from freeze- dried microalgae by experimental design. A maximum protein extraction yield (78.38%) was obtained under the following optimal maceration conditions: A freeze-dried biomass concentration of 7.5 g.L-1, a temperature of 20°C and a pH equal to 12, with 2 hours of extraction. However, the recovery of soluble proteins following treatment by the extrusion process was significantly affected by the temperature, flow rate and screw rotation speed. Under optimised extrusion conditions, the maximum protein yield reached 25.02% for a screw rotation speed of 400 rpm, a temperature of 25°C and a flow rate of 1 kg.h-1after 15 min of extraction. Thus a coupling between maceration/extrusion, to obtain a protein yield of 27.10% at 5h of extraction. The second part focused on the recovery of soluble proteins after maceration, by filtration on membranes with different cut-off thresholds. Filtration using all the membranes was almost identical, concentrating the proteins to a purity of between 13-16%. Filtration on a 300 kDa membrane showed a 67% increase in protein recovery in the retentate compared with filtration on 3 kDa, 15 kDa, 50 kDa and 150 kDa. Selectivity was always less than 1 for all membranes
Yusuf al-Sebai and Thematic and Technical Review of His Novel Called “Ardh al-Nefaq”
No full textYüksek Lisans TeziModern Arap Edebiyatının önde gelen şahsiyetlerinden olan Yusuf es-Sibâʽî, Mısır halkı tarafından çok değer gören biri olmuştur. Aynı zamanda
siyasetçi ve gazeteci olan edip, eserlerinde toplumsal problemlere yer vererek
halkın sorunlarına çözüm yolu aramıştır. Sade ve süssüz üslubu ile halk
içerisinden biri gibi davranarak eserlerini kaleme almıştır. Kendisini toplumsal
sorunlara adayan es-Sibâʽî, romantizm, realizm, mizah ve fantastik türleri aynı
kapta harmanlamış, bu hali ile okuyucuların beğenisine sunmuştur.
Çalışma giriş, birinci bölüm ve ikinci bölümden oluşmaktadır. Giriş
bölümünde Mısır’ın modernleşme süreci ile Mısır’da roman hakkında bilgi
verilmiştir. Birinci bölümde yazarın hayatı, gençlik yılları, vefatı ve edebi
kişiliği incelenmiştir. İkinci bölümde ise Arzu’n-Nifâk romanı teknik ve tematik
açıdan tahlil edilmiştir.Yusuf al-Sebai, one of the prominent figures of modern Arabic literature,
has been appreciated by the Egyptian people. This literary man, who is also a
politician and journalist, sought a solution to the problems of the people by
including social problems in his works. He acted like one of the people and wrote
his works with unsophisticated and unembellished style. Sibâ'i devoted himself to
social problems and combined romanticism, realism, humor and fantasy genres
in the same pages and presented it to the readers in this form.
The present study consists of an introduction and two main chapters. In
the part of introduction, information about the modernization process of Egypt
and the novel in Egypt have been given. In the first chapter, the life, youth and
death of the author has been examined. Furthermore, the author's literary
personality has been analyzed. Subsequently, in the second part, " Ardh al-Nefaq" has been evaulated in terms of technique and thematic
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