3,077 research outputs found
Jennie will you love? Jennie will you love me? Jennie will you love? [first line of chorus]
No full textstrophic with choruspiano and voiceTo Miss Ellen E. Rider.Johns Hopkins University, Levy Sheet Music Collection, Box
035, Item 119Written and Composed By John H. Hewitt.Sung with great Applause by Mr. N. Collins.Gillingha
Jennie will you love? Jennie will you love me? Jennie will you love? [first line of chorus]
No full textstrophic with choruspiano and voiceTo Miss Ellen E. Rider.Johns Hopkins University, Levy Sheet Music Collection, Box
035, Item 119Written and Composed By John H. Hewitt.Sung with great Applause by Mr. N. Collins.Gillingha
Post cards (4) 1890
No full text(1) Post card to Peter H.L. Bradt, Jordan from J.E. Beckett, dated at Hewitt, 11 March
1890, inquiring about a farm rental.
(2) Post card to Peter Bradt, Jordan, Ont. from H. Truman, dated at Homer, 30 April
1890. Truman writes “when you are ready to thresh your hay let me know & I will
come & see it is properly done…”
(3) Post card to P.H.L. Bradt, Pelham Union, dated at Woodstock, 18 August 1890.
The name of the writer is unclear. The note states “…sorry wd like to have seen
you…come up and see us when you get the chance—could you?”
(4) Post card to Peter H.L. Bradt, Jordan, Ont. from Bowes & McWilliams, dated at
Montreal, 16 September 1890, re: an order of pears and apples
Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs
No full textMuscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying mechanisms and treatments of muscular dystrophies, analogous strength-based measurements in this disease model are lacking. Here we describe the first demonstration of the direct measurement of muscular strength in dystrophin-deficient C. elegans mutants using a micropillar-based force measurement system called NemaFlex. We show that dys-1(eg33) mutants, but not dys-1(cx18) mutants, are significantly weaker than their wild-type counterparts in early adulthood, cannot thrash in liquid at wild-type rates, and display mitochondrial network fragmentation in the body wall muscles as well as abnormally high baseline mitochondrial respiration. Furthermore, treatment with prednisone, the standard treatment for muscular dystrophy in humans, and melatonin both improve muscular strength, thrashing rate, and mitochondrial network integrity in dys-1(eg33), and prednisone treatment also returns baseline respiration to normal levels. Thus, our results demonstrate that the dys-1(eg33) strain is more clinically relevant than dys-1(cx18) for muscular dystrophy studies in C. elegans. This finding in combination with the novel NemaFlex platform can be used as an efficient workflow for identifying candidate compounds that can improve strength in the C. elegans muscular dystrophy model. Our study also lays the foundation for further probing of the mechanism of muscle function loss in dystrophin-deficient C. elegans, leading to knowledge translatable to human muscular dystrophy
Recommended from our members
Preliminary Geologic Map of the North Half of the Union Pass Quadrangle, Mohave County, Arizona
No full textPreliminary Geologic Map of the North Half of the Union Pass Quadrangle, Mohave County, Arizona. Includes one map sheet with cross section at 1:24,000 map scale.On 1/17/2014, F.L. Hillemeyer's name was removed from the author list per his request. (The request was forwarded to AZGS by J.E. Faulds.)Documents in the AZGS Document Repository collection are made available by the Arizona Geological Survey (AZGS) and the University Libraries at the University of Arizona. For more information about items in this collection, please contact [email protected]
Building and Defining Behavioral Economics
No full textContains fulltext :
95156.pdf (Publisher’s version ) (Closed access)George Loewenstein, a prominent behavioral economist, recalls thatIn 1994, when Thaler, Camerer, Rabin, Prelec and I spent the year at the Center for Advanced Study in the Behavioral Sciences, we had a meeting to make a kind of final decision about what to call what we were doing. Remarkably, at that time, the name behavioral economics was not yet well established. I actually advocated “psychological economics,” and Thaler was strong on behavioral economics. I'm kind of glad that he prevailed; I think it's a better, catchier, label, although it creates confusion due to association with Behaviorism. (G. Loewenstein, personal email to author, June 16, 2008
The IPHAS catalogue of H alpha emission-line sources in the northern Galactic plane
No full textWe present a catalogue of point-source H alpha emission-line objects selected from the INT/WFC Photometric Ha Survey (IPHAS) of the northern Galactic plane. The catalogue covers the magnitude range 13 <= r' <= 19.5 and includes Northern hemisphere sources in the Galactic latitude range -5 degrees < b < 5 degrees. It is derived from similar to 1500 deg(2) worth of imaging data, which represents 80 per cent of the final IPHAS survey area. The electronic version of the catalogue will be updated once the full survey data become available. In total, the present catalogue contains 4853 point sources that exhibit strong photometric evidence for Ha emission. We have so far analysed spectra for similar to 300 of these sources, confirming more than 95 per cent of them as genuine emission-line stars. A wide range of stellar populations are represented in the catalogue, including early-type emission-line stars, active late-type stars, interacting binaries, young stellar objects and compact nebulae.
The spatial distribution of catalogue objects shows overdensities near sites of recent or current star formation, as well as possible evidence for the warp of the Galactic plane. Photometrically, the incidence of Ha emission is bimodally distributed in (r' - i'). The blue peak is made up mostly of early-type emission-line stars, whereas the red peak may signal an increasing contribution from other objects, such as young/active low-mass stars. We have cross-matched our H alpha-excess catalogue against the emission-line star catalogue of Kohoutek & Wehmeyer, as well as against sources in SIMBAD. We find that fewer than 10 per cent of our sources can be matched to known objects of any type. Thus IPHAS is uncovering an order of magnitude more faint (r' > 13) emission-line objects than were previously known in the Milky Way
Testing protoplanetary disc dispersal with radio emission
No full textWe consider continuum free–free radio emission from the upper atmosphere of protoplanetary discs as a probe of the ionized luminosity impinging upon the disc. Making use of previously computed hydrodynamic models of disc photoevaporation within the framework of extreme-ultraviolet (EUV) and X-ray irradiation, we use radiative transfer post-processing techniques to predict the expected free–free emission from protoplanetary discs. In general, the free–free luminosity scales roughly linearly with ionizing luminosity in both EUV- and X-ray-driven scenarios, where the emission dominates over the dust tail of the disc and is partial optically thin at cm wavelengths. We perform a test observation of GM Aur at 14–18?GHz and detect an excess of radio emission above the dust tail to a very high level of confidence. The observed flux density and spectral index are consistent with free–free emission from the ionized disc in either the EUV- or the X-ray-driven scenario. Finally, we suggest a possible route to testing the EUV- and X-ray-driven dispersal model of protoplanetary discs, by combining observed free–free flux densities with measurements of mass-accretion rates. On the point of disc dispersal one would expect to find an M?2? scaling with free–free flux in the case of EUV-driven disc dispersal or an ?* scaling in the case of X-ray-driven disc dispersa
The Benefits of Being Economics Professor A (and not Z)
No full textAlphabetic name ordering on multi-authored academic papers, which is the convention in the economics discipline and various other disciplines, is to the advantage of people whose last name initials are placed early in the alphabet. As it turns out, Professor A, who has been a first author more often than Professor Z, will have published more articles and experienced afaster growth rate over the course of her career as a result of reputation and visibility. Moreover, authors know that name ordering matters and indeed take ordering seriously: Several characteristics of an author group composition determine the decision to deviate from the default alphabetic name order to a significant extent.performance measurement, incentives, economists, name ordering
Pinchi Lake Mercury Belt, British Columbia:
No full textby J.E. Armstrong.Paper (Geological Survey of Canada) ; 42-11
- …
