2,013 research outputs found
A new heuristic for the total tardiness problem with parallel machines
No full textBiskup D, Herrmann J. A new heuristic for the total tardiness problem with parallel machines. Discussion paper / Fakultät für Wirtschaftswissenschaften, Universität Bielefeld. Bielefeld: Universität Bielefeld; 2007.Scheduling jobs against due dates is one of the most important and best examined objectives in scheduling theory and practice. In this paper the parallel machine version of the well-known total tardiness problem is considered. The objective is to minimize the total tardiness of the jobs, while for all jobs an individual due date is given. The single machine version has been proven to be NP-hard, hence it is unlikely to find polynomially bounded optimization algorithms. Consequently, we concentrate on developing an efficient heuristic. Our extensive computational results confirm that our new heuristic is capable to deliver near optimal results
Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex
No full textCampylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation
Die Römische Republik /
No full textWer sich für antike Geschichte interessiert, greift zu dieser knappen und gut lesbaren Geschichte der Römischen Republik, geschrieben von einem der bekanntesten Althistoriker Deutschlands. Jochen Bleicken (1926-2005) führt den Leser von der Zeit der Etrusker bis zum Ende der Republik, das die Herrschaft Caesars besiegelte. Alle wichtigen Phasen der republikanischen Geschichte entfalten sich: die Ständekämpfe, Aufstieg Roms zur Weltherrschaft - und die zugehörigen ungeheuren kriegerischen Auseinandersetzungen -, Ursachen und Beginn der inneren Krise seit den Gracchen, die Restauration unter Sulla und schließlich: die Auflösung der Republik und die Begründung der Monarchie. Aloys Winterling Jochen Bleicken, 1926-2005, war Professor für Alte Geschichte an der Universität Göttingen und u.a. Mitherausgeber von "Oldenbourg Grundriss der Geschichte" und der HISTORISCHEN ZEITSCHRIFT.Wer sich für antike Geschichte interessiert, greift zu dieser knappen und gut lesbaren Geschichte der Römischen Republik, geschrieben von einem der bekanntesten Althistoriker Deutschlands. Jochen Bleicken (1926-2005) führt den Leser von der Zeit der Etrusker bis zum Ende der Republik, das die Herrschaft Caesars besiegelte. Alle wichtigen Phasen der republikanischen Geschichte entfalten sich: die Ständekämpfe, Aufstieg Roms zur Weltherrschaft - und die zugehörigen ungeheuren kriegerischen Auseinandersetzungen -, Ursachen und Beginn der inneren Krise seit den Gracchen, die Restauration unter Sulla und schließlich: die Auflösung der Republik und die Begründung der Monarchie. Aloys Winterling Jochen Bleicken, 1926-2005, war Professor für Alte Geschichte an der Universität Göttingen und u.a. Mitherausgeber von "Oldenbourg Grundriss der Geschichte" und der HISTORISCHEN ZEITSCHRIFT.Mode of access: Internet via World Wide Web.Description based on online resource; title from PDF title page (publisher's Web site, viewed 08. Jul 2019
Synthesis of 2,3,6,7-tetrabromoanthracene
No full textSchäfer C, Herrmann F, Mattay J. Synthesis of 2,3,6,7-tetrabromoanthracene. Beilstein Journal of Organic Chemistry. 2008;(4): 41.The first synthesis of 2,3,6,7-tetrabromoanthracene is presented, starting from benzene in a straightforward four step synthesis
Lithium extraction from geothermal brines in the Upper Rhine Graben: A case study of potential and current state of the art
No full texthttp://dx.doi.org/10.13039/501100006360 BMWKhttp://dx.doi.org/10.13039/100021130 Bundesministerium für Wirtschaft und Klimaschut
Essentials of services marketing / Jochen Wirtz, Christopher Lovelock.
No full textIncludes bibliographical references and indexes.(xxxii, 670 pages) :Essentials of Services Marketing, 3e, is meant for courses directed at undergraduate and polytechnic students, especially those heading for a career in the service sector, whether at the executive or management level. It delivers streamlined coverage of services marketing topics with an exciting global outlook with visual learning aids and clear language. It has been designed so that instructors can make selective use of chapters and cases to teach courses of different lengths and formats in either services marketing or services management
Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma Effects on treatment-related side effects and survival
No full textBackground Primary chemoradiotherapy (CRT) is the standard treatment for locally advanced anal carcinoma. This study compared volumetric intensity-modulated arc therapy (VMAT) to 3-dimensional conformal radiotherapy (3DCRT) in terms of treatment-related side effects and survival. Patients and methods From 1992-2014, 103 consecutive patients with anal carcinoma UICC stage I-III were treated. Concomitant CRT consisted of whole pelvic irradiation, including the iliac and inguinal lymph nodes, with 50.4 Gy (1.8 Gy per fractions) by VMAT (n = 17) or 3DCRT (n = 86) as well as two cycles of 5-fluorouracil and mitomycin C. Acute organ and hematological toxicity were assessed according to the Common Terminology Criteria (CTC) for Adverse Events version 3.0. Side effects a parts per thousand yen grade 3 were scored as high-grade toxicity. Results High-grade acute organ toxicity CTC a parts per thousand yenaEuro parts per thousand 3 (P < 0.05), especially proctitis (P = 0.03), was significantly reduced in VMAT patients. The 2-year locoregional control (LRC) and disease-free survival (DFS) were both 100 % for VMAT patients compared with 80 and 73 % for 3DCRT patients. Conclusion VMAT was shown to be a feasible technique, achieving significantly lower rates of acute organ toxicity and promising results for LRC and DFS. Future investigations will aim at assessing the advantages of VMAT with respect to late toxicity and survival after a prolonged follow-up time
Einzel- und Paarintervention für depressive Koronarpatienten
No full textDepressive symptoms in patients presenting with coronary heart disease have an impact on quality of life, health behavior, and prognosis. The psychotherapeutic interventions which had been tested for their efficacy in previous randomized controlled trials, showed only minor effects. A stepwise approach consisting of individual and group psychotherapeutic interventions was tested for efficacy in a German multicenter study. The presented paper describes the therapeutic procedure for two individual sessions and one couple session by means of case examples. The main focus was to determine depressive symptoms along with underlying maladaptive personality traits such as negative affectivity and social inhibition (type D pattern). Depressive mood, disappointments and mortifications both in private and professional life and also during the previous treatment are verbalized. Dysfunctional relation patterns and maladaptive sickness behavior are taken up by the psychotherapist and alternative behavior patterns are developed. The objective of the couple session is strengthening the partnership resources and offering relief of fears and worries relative to the heart disease. The psychotherapeutic procedure is psychodynamically oriented but also contains cognitive-behavioral and interactional treatment approaches
Analysis, interpretation, and the local dimension of economic transformation: What went wrong and why?
No full textTransformation has been put in motion by a variety of both endogenous and exogenous forces. Although not any process was under the control of those countries, their choice of goals and instruments was anyway particularly great, at least theoretically. However, transformation was implemented as a rather narrowly defined and technically circumscribed problem-solving process aiming at applying sound general principles of economics and management to reach well-defined goals. It turned out to generate new problems and resulted in different outcomes in different countries and, within individual countries, in different territories. This paper treats transformation as innovation and considers that it had to deal with different dimensions, including both general principles and local features, opportunities, and constraints, and both analysis based on problem-solving, and interpretation of the new situation. These dimensions should have been managed simultaneously, but failed to do so. The paper provides a general explanation for the failure in managing simultaneously the various components of transformation and considers what the 2008 international crisis has revealed of the implementation of 20 years of transformation.Transformation, Local development, Reform, Analysis, Interpretation, Crisis, Washington Consensus, Innovation
Do They Always Say No? German Consumers and Second-Generation GMO Foods
No full textEuropean consumers and, in particular, German consumers are known to be very critical towards the introduction of genetically modified (GM) foods. It is analyzed here whether German consumers do reject second-generation GMO foods, too. Whereas first-generation GM crops induced producer-related benefits, second-generation GM crops are associated with consumer-oriented benefits like an improvement of nutritional quality. The determinants of demand for second-generation GM rapeseed oil are investigated within an online survey of 1556 German consumers. It is elaborated how two functional properties of that product matter; i.e. long-chain ϖ3 fatty acids and the cholesterol-lowering effect of phytosterols. It turns out that GMO rapeseed oil is neglected by 74 % of all respondents. Output traits, however, will increase the probability of purchases of GMO rapeseed oil. This is more the case for long-chain ϖ3 fatty acids than for phytosterols.consumer behavior, second generation, GMO foods, rapeseed oil, Consumer/Household Economics, Food Consumption/Nutrition/Food Safety,
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