1,720,970 research outputs found
Faktor Risiko dari Rekurensi Kanker Payudara pada populasi Asia: studi Meta-Analisis
No full textRecurrence of breast cancer is a poor prognostic factor that causes the highest incidence and mortality of breast cancer. Based on a report from Global Cancer Observatory (GLOBOCAN) 2O2O, Asia has first rank for new cases and mortality for 5 consecutive years. According to researchers at the ESMO 2020 virtual congress, Asia has the highest proportion of breast cancer recurrence factors compared to non Asia Regions. Several researchers have described the factors for breast cancer recurrence in general, but there is no recent study reporting significant factors for breast cancer recurrence in Asia. Aim. To analyze risk factors from breast cancer recurrence and non recurrence in Asian populations through a meta-analyses approach.Methods. literature search was carried out on 4 databases, Pubmed, ProQuest, Cochrane and Google Scholar until October 2021 with Odds Ratio (OR) of several risk factors according to PRISMA guidelines. This study using relevant keywords and reviewing quality based on New Ottawa Scale (NOS) assessment. The cumulative odds ratio (OR) parameters between studies was analyzed based on the heterogenity test of the fixed effect model (FEM) or random effect model (REM). Result.6 studies obtained on risk factors for breast cancer recurrence found a total of 53.647 patients. Risk factors of age (OR 0,36; CI95%: 0,13-1,01; p=0,05), pathological stage (OR 2,36; CI95%: 1,27- 4,38; p=0,007), ER+ (OR 0,37; CI95%: 0,15-0,93; p=0,03), HER2+ (OR 0,85; CI95%: 0,42-1,73; p=0,65), adjuvant chemotherapy (OR 0,62; CI95%: 0,15-2,52; p=0,51) and radiotherapy (OR 0,90; CI95%: 0,39- 2,05; p=0,79).Conclusion. Risk factors of breast cancer recurrence from Asia population are significant to ER+.Kekambuhan kanker payudara merupakan salah satu prognostik buruk yang menyebabkan jumlah insiden dan mortalitas tertinggi kanker payudara. Berdasarkan laporan dari Global Cancer Observatory (GLOBOCAN) 2020 Asia menempati urutan pertama untuk kasus baru dan mortalitas selama 5 tahun berturut-turut. Menurut peneliti pada kongres virtual ESMO 2020 Asia memiliki proporsi faktor kekambuhan kanker payudara tertinggi dibandingkan dengan wilayah non Asia. Beberapa peneliti telah menjelaskan faktor faktor kekambuhan kanker payudara secara umum, namun belum ada penelitian terbaru yang melaporkan faktor faktor signifikan terjadinya kekambuhan kanker payudara di Asia. Tujuan. Untuk menganalisis faktor risiko dari kelompok rekurensi dan non rekurensi kanker payudara pada populasi Asia melalui pendekatan meta-analisis.Metode.Penelusuran literatur dilakukan pada 4 database, yaitu Pubmed, ProQuest, Cochrane dan Google Scholar sampai Oktober 2021 dengan Odds Rasio (OR) beberapa faktor risiko sesuai dengan panduan PRISMA menggunakan kata kunci yang relevan serta telaah kualitas jurnal berdasarkan penilaian New Ottawa Scale (NOS). Parameter kumulatif Odds Rasio (OR) antar penelitian dianalisis berdasarkan uji heterogenitas fixed effect model (FEM) atau random effect model (REM). Hasil Keenam studi yang diperoleh pada faktor risiko rekurensi kanker payudara didapatkan total pasien sebanyak 53.647. Faktor risiko usia (OR 0,36; IK95%: 0,13-1,01; p=0,05), stadium patologis (OR 2,36; IK95%: 1,27- 4,38; p=0,007), ER+ (OR 0,37; IK95%: 0,15-0,93; p=0,03), HER2+ (OR 0,85; IK95%: 0,42-1,73; p=0,65), kemoterapi ajuvan (OR 0,62; IK95%: 0,15-2,52; p=0,51) dan radioterapi (OR 0,90; IK95%: 0,39- 2,05; p=0,79). Kesimpulan. Faktor risiko dari rekurensi kanker payudara pada populasi Asia yang terbukti signifikan adalah faktor ER+.85 halamanSkripsi Sarjan
Clinicopathlogical Characteristics of Breast Tumor Patients at Prof. Hospital. Dr. Chairrudin P. Lubis University of North Sumatera in 2023
No full textBackground. This study was used to identify the characteristics of patients with benign
and malignant breast tumors, as well as factors that influence the diagnosis. Objective.
This study aims to show the prevalence of benign and malignant breast tumors and their
characteristics. Method. The study was conducted with a descriptive approach using
secondary data from patient medical records at Prof. dr. Chairuddin P. Lubis Hospital,
University of North Sumatra. Results. The study showed that benign breast tumors were
mostly found in patients under 30 years of age, which was 60.6%. The most common type
of benign breast tumor was fibroadenoma mammae, which reached 69.7%. Meanwhile,
malignant breast tumors were more commonly found in patients aged 41-50 years
(37.9%) and were dominated by the histopathological type of invasive carcinoma of no
special type (80.3%). In addition, patients with malignant breast tumors tended to have
positive LVI status (59.1%) and high histopathological grading grade III, which indicated
the possibility of cancer cells spreading to other organs. Malignant breast tumor patients
were mostly unemployed (65.2%) and married (83.3%), while benign breast tumors were
more common in unmarried patients (60.6%). Most malignant breast tumor patients were
postmenopausal (63.6%). In terms of histopathology, this study showed that malignant
breast tumors generally had a histopathological type of invasive carcinoma of no special
type (80.3%), with a high histopathological grade of grade III of 63.6%, and positive LVI
status (59.1%). Conclusion. The results of this study can be used as health education
about breast tumors and to strengthen early detection programs through routine
examinations to reduce the incidence of breast cancer in advanced stages.82 PagesSkripsi Sarjan
Karakteristik Penderita Kanker Payudara di Rumah Sakit Umum Pendidikan Haji Adam Malik Tahun 2014-2016
No full textLatar belakang. Kanker payudara memiliki prevalensi yang cukup tinggi baik di negara
berkembang maupun negara maju dikarenakan peningkatan morbiditas dan mortalitas selama
bertahun-tahun. Berdasarkan Pathological Based Registration di Indonesia, KPD menempati
urutan pertama dengan frekuensi relatif sebesar 18,6% dan lebih dari 80% kasus ditemukan
berada pada stadium yang lanjut, dimana upaya pengobatan sulit dilakukan. Tujuan. Penelitian
ini bertujuan untuk memperoleh karakteristik umum dan khusus penderita kanker payudara di
Rumah Sakit Umum Pusat Haji Adam Malik tahun 2014-2016. Metode. Rancangan penelitian
bersifat obervasional dengan metode deskriptif. Pengambilan sampel dilakukan dengan
menggunakan teknik total sampling. Hasil penelitian. Berdasarkan karakteristik umum, mayoritas
penderita kanker payudara berusia 40-49 tahun yang berjumlah 33 orang (34,7%), berpendidikan
SMA dengan jumlah 41 orang (43,2%), tidak bekerja dengan jumlah 65 orang (68,4%), dan tidak
memiliki riwayat keluarga yang berjumlah 91 orang (95,8%). Berdasarkan karakteristik khusus,
mayoritas penderita kanker payudara berada pada stadium IIIB yang berjumlah 42 orang
(44,2%) dengan ukuran tumor T4b berjumlah 50 orang (52,6%), stage N1 berjumlah 40 orang
(42,1%), dan bermetastasis di paru berjumlah 11 orang (40,7%) pada stadium IV, terdiagnosis
dengan gambaran IDC dengan jumlah 68 orang (71,6%), ER berstatus negatif dengan jumlah 70
orang (73,7%), 67 orang (70,5%) dengan PR berstatus negatif, 31 orang (32,6%) dengan her2
bernilai positif, dan 49 orang (51,6%) dengan ki-67 berstatus positif. Kesimpulan. Kanker
payudara di RSUP Haji Adam Malik sebagian besar dialami oleh wanita usia muda yang tidak
bekerja dan sudah berada pada stadium IIIB dan IV.Background. Breast cancer has a high prevalence in both developing and developed countries due
to years of increased morbidity and mortality. Based on Pathological Based Registration in
Indonesia, KPD ranks first with a relative frequency of 18.6% and more than 80% of cases are
found at an advanced stage, where treatment efforts are difficult. Aim. This study aims to obtain
general and specific characteristics of breast cancer patients at RSUP Haji Adam Malik in 2014-
2016. Method. The research was designed in observational with descriptive method. The sampling
had been done using total sampling technique. Results. Based on the general characteristics, the
majority of breast cancer patients were 33 people aged 40-49 years (34.7%), 41 people (43.2%)
finished high school education, 65 people (68.4%) did not work, and 91 people (95.8%) did not
have a family history. Based on special characteristics, the majority of breast cancer sufferers
were in stage IIIB, amounting 42 people (44.2%) with T4b tumor size totaling 50 people (52.6%),
stage N1 numbering 40 people (42.1%), and metastasizing in the lung were 11 people (40.7%) in
stage IV. There were 68 people (71.6%) diagnosed with IDC, 70 people (73.7%) with negative
status of ER, 67 people (70.5 %) with negative status of PR, 31 people (32.6%) with positive
values of her2, and 49 people (51.6%) with positive status of ki-67. Conclusions. Most breast
cancers at RSUP Haji Adam Malik were experienced by young women who did not work and were
already in stage IIIB and IV.Skripsi Sarjan
Hubungan Lama Pertumbuhan Nodul Tiroid dengan Kejadian Karsinoma Tiroid di RSUP Haji Adam Malik 2020-2023
No full textIntroduction. Thyroid carcinoma is one of the endocrine malignancies that is
quite dangerous and is recorded to occupy 1 - 4% of all malignancies in the
world. One of the most common clinical manifestations is thyroid nodules. The
duration from the appearance of a thyroid nodule until the patient consults a
doctor is not yet known for certain whether it influences the development of the
nodule into a malignancy. Objective. To determine the relationship between the
duration of thyroid nodule growth and the incidence of thyroid carcinoma at H.
Adam Malik General Hospital for the period January 2020 – September 2023.
Method. The research design uses observational analytical methods with a crosssectional
approach. The sampling technique was carried out using total sampling,
where the population in this study was 173 people, including 92 thyroid
carcinoma patients and 81 benign thyroid nodule patients at the H. Adam Malik
Medan Central General Hospital in 2020 - 2023. Results and discussion. The
majority of thyroid carcinoma patients have duration od nodules 3 - 5 years
(27.2%), whereas in patients with benign thyroid nodules it takes 1 - 2 years
(37.0%) before consulting a doctor. Based on the results of chi-square analysis, it
shows that there is no significant relationship between the duration of thyroid
nodules growth and the incidence of thyroid carcinoma as evidenced by the pvalue
>0.05 (0.109). Conclusion. There is no significant relationship between the
duration of thyroid nodule growth and the incidence of thyroid carcinoma. The
prevalence of thyroid carcinoma patients reached 53%, while that of benign
thyroid nodule patients reached 47%.95 HalamanSkripsi Sarjan
Karakteristik Penderita Kanker Payudara Berdasarkan Usia Menarche di Rumah Sakit Umum Pusat Haji Adam Malik Tahun 2014-2017
No full textLatar belakang. Kanker payudara merupakan penyakit kanker yang sering didiagnosis di dunia. Kanker payudara terjadi akibat pertumbuhan sel payudara yang abnormal sehingga menjadi ganas. Di Indonesia, kanker payudara merupakan kanker yang paling sering terjadi pada perempuan.Hingga saat ini, penyebab kanker payudara belum diketahui dengan jelas. Ada banyak faktor risiko yang dapat meningkatkan terjadinya kanker payudara salah satunya adalah usia menarche (menstruasi pertama) dini. Tujuan. Penelitian ini bertujuan untuk memperoleh karakteristik penderita kanker payudara berdasarkan usia menarche di Rumah Sakit Umum Pusat Haji Adam Malik tahun 2014-2017. Metode. Rancangan penelitian bersifat obervasional dengan metode deskriptif. Pengambilan sampel dilakukan dengan menggunakan teknik total sampling. Hasil Penelitian. Berdasarkan karakteristik umum, sebagian besar penderita kanker payudara berusia 40-49 tahun (38,5%), telah menyelesaikan pendidikan SMA (45,2%), tidak bekerja (66,3%), dan tidak memiliki riwayat keluarga (94,2%).Secara umum, sebagian besar penderita kanker payudara berada pada stadium IIIB (41,3%), terdiagnosis dengan gambaran Invasive Ductal Carcinoma (78,8%). Mayoritas memiliki reseptor estrogen (ER) berstatus negatif (67,3%), reseptor progesteron negatif (65,4%), her2 bernilai positif (33,6%), dan ki-67 berstatus positif (55,7%). Mayotitas penderita kanker payudara memiliki usia menarche ≤ 12 tahun yang berjmlah 53 orang (51%). Berdasarkan usia menarche, pasien dengan menarche dini mengalami kanker payudara stadium III, tetapi tidak memberikan gambaran spesifik terhadap histopatologi dan imunohistokimia Kesimpulan.Usia menarche hanya memberikan gambaran karakteristik pada stadium tetapi tidak memberikan karakteristik spesifik terhadap distribusi histopatologi dan immunohistokimia.Background. Breast cancer is one of the most diagnosed cancer in the world. Breast cancer starts when the breast cell grows abnormally and turns malignant. In Indonesia, breast cancer is the most diagnosed cancer in women.Up to now, the cause of breast cancer has not been identified yet. There are many factors that increases the risk of breast cancer, one of them is the early age of menarche. Objective. This study aims to obtain characteristics of breast cancer patients based on age of menarche in RSUP Haji Adam Malik in 2014-2017. Method. The study was designed in observational with descriptive method. The sampling had been done using total sampling technique. Results. Based on general characteristics, the majority of breast cancer patients are in the range of 40-49 years old (38,5%), graduated high school (45,2%), unemployed (66,3%), and do not have family history (94,2%). Majority of patients have stadium IIIB breast cancer (41,3%). The most diagnosed histopathology is Invasive Ductal Carcinoma (78,8%). Majority of breast cancer patients have negative estrogen receptor (67,3%), negative progesterone receptor (67,3%), negative her2 (66,3%) and positive ki-67 (67,3%). Fifty three breast cancer patients (51%) have early menarche. Based on the age of menarche, the patient with early menarche mostly has stage three breast cancer, but the age of menarche does not give a specific characteristic in histopathology and immunohistochemistry. Conclusion. Age of menarche gives specific characteristic in staging but not in histopathology and immunohistochemistry.84 HalamanSkripsi Sarjan
Effectiveness of Doxorubicin and Paclitaxel Chemotherapy Regimens on Tumor Size of Breast Cancer Patients at Prof. Dr. Chairuddin P. Lubis Hospital, University of North Sumatra in 2023-2024
No full textIntroduction: Breast cancer (BC) is a leading cause of cancer mortality in women globally, with rising incidence in Indonesia. Neoadjuvant chemotherapy (NAC), particularly the combination of doxorubicin and paclitaxel, is effective in locally advanced BC for reducing tumor size, lowering cancer stage, and improving breast-conserving surgery rates. This study evaluates the efficacy of this regimen in tumor size reduction among BC patients treated at Prof. Dr. Chairuddin P. Lubis Hospital, Universitas Sumatera Utara.
Methods: This observational analytic study utilized a cross-sectional design with secondary data from medical records of BC patients treated with doxorubicin and paclitaxel chemotherapy between January 2023 and December 2024. Inclusion criteria included locally advanced BC, histopathological confirmation, and completion of at least three chemotherapy cycles. Tumor size reduction was evaluated using WHO RECIST criteria, and data were analyzed with the Chi-square test.
Results: Sixty patients (mean age 48.28 ± 8.89 years) were included, with most being stage III (58.3%), grade 2 (50%), and histologically categorized as no special type (75%). Tumor size decreased significantly from 6.52 ± 3.62 cm to 4.57 ± 2.48 cm (p < 0.001). Based on WHO criteria, 36 patients (60%) achieved partial response, while 24 (40%) had stable disease. No cases of complete response or progressive disease were observed. A significant association between chemotherapy and tumor size reduction was identified (p < 0.001).
Discussion: The combination of doxorubicin and paclitaxel demonstrated significant efficacy in tumor size reduction for advanced BC, particularly in non-special type histology. The findings align with previous studies but underscore the need for personalized treatment approaches for subtypes such as triple-negative BC, which may exhibit lower response rates.
Conclusion: The doxorubicin and paclitaxel regimen effectively reduced tumor size in patients with locally advanced BC. While it is suitable for non-special type and stage III BC, personalized strategies should be explored for improving outcomes in specific subtypes.80 PagesTesis Magiste
Overexpression Human Epidermal Growth Factor (Her-2) Sebagai Faktor Prediktor Metastasis Kelenjar Getah Bening Sentinel Pada Kanker Payudara Stadium Awal Di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas Sumatera Utara
No full text67Introduction: Breast cancer is a malignancy in breast tissue that can originate
from the ductal epithelium or lobules. Axillary lymph node status has become one
of the strongest prognostic factors in women with early stage breast cancer.
Several studies have been conducted to evaluate the relationship of HER-2 with
detection, metastasis, and prognosis of breast cancer. This study is aimed at
evaluating overexpression of HER2 as a prognostic factor in breast cancer with
sentinel lymph node metastases.
Methods: This is an analytic study with cross sectional research design.
Results: In this study, a sample of 51 people was obtained. Most types of breast
cancer are invasive ductal carcinoma in 40 patients (78.4%), then invasive no
other specific type in 7 patients (13.7%), then invasive lobular carcinoma and
DCIS in 2 patients (3.9%). From the results of statistical tests found no
relationship between overexpression of HER-2 with sentinel lymph node
metastases (p = 0.255). Patients who had HER2 expression had a 1.477 times
greater risk of having sentinel lymph node metastases compared to a group of
patients with no HER2 expression.
Conclusion: There is no relationship between HER-2 overexpression with the
occurrence of sentinel lymph node metastases.Kanker payudara merupakan keganasan pada jaringan payudara yang dapat
berasal dari epitel duktus maupun lobulusnya. Kanker payudara adalah kanker
yang paling sering ditemukan pada wanita, dengan angka insidensi 43,1 per
100.000 orang. Diperkirakan terdapat 1.671.149 kasus baru kanker payudara yang
terdiagnosis pada tahun 2012. Status kelenjar getah bening aksila telah menjadi
salah satu faktor prognostik terkuat pada wanita dengan kanker payudara stadium
awal. (Schröder et al., 2018) Diseksi kelenjar getah bening (ALND) telah lama
digunakan sebagai metode untuk mengidentifikasi metastasis kelenjar getah
bening aksila, dan saat ini sudah mulai digantikan dengan metode lain yang lebih
non-invasif yaitu biopsy kelenjar getah bening sentinel (SLNB). Biopsi kelenjar
getah bening sentinel merupakan suatu teknik invasif minimal yang dapat
mengkonfirmasi adanya metastasis kelenjar getah bening regional pada kanker.
(Nieweg, Uren, & Thompson, 2015) Biopsi kelenjar getah bening sentinel dapat
dilakukan dengan beberapa teknik mapping limfatik yaitu dengan mengunakan
blue-dye, radiotracer atau kombinasi keduanya.
Penelitian ini merupakan penelitian analitik dengan desain penelitian cross
sectional. Penelitian dilakukan di rumah sakit pendidikan FK USU. Sampel
penelitian ini adalah penderita kanker payudara yang memenuhi kriteria inklusi
dan eksklusi di rumah sakit pendidikan FK USU. Data yang sudah dikumpulkan,
diolah, dan dianalisis melaui statistik dan disajikan dalam bentuk tabel. Data
dianalisis dengan menggunakan uji chi square.
Berdasarkan penelitian ini, didapatkan jenis kanker terbanyak adalah invasive
ductal carcinoma. Secara histologi, ditemukan paling banyak kanker payudara
dengan grade 3. Ukuran tumor yang di dapatkan pada T2 dengan 40 pasien
(86,3%). Dari pemeriksaan immunohistokimia dan pemeriksaan sentinel biopsi
didapatkan bahwa tidak ada hubungan antara overexpression HER-2 dengan
terjadinya metastasis kelenjar getah bening sentinel (P > 0,05).Tesis Magiste
Overexpression Human Epidermal Growth Factor (Her-2) Sebagai Faktor Prediktor Metastasis Kelenjar Getah Bening Sentinel Pada Kanker Payudara Stadium Awal Di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas Sumatera Utara
No full text67Introduction: Breast cancer is a malignancy in breast tissue that can originate
from the ductal epithelium or lobules. Axillary lymph node status has become one
of the strongest prognostic factors in women with early stage breast cancer.
Several studies have been conducted to evaluate the relationship of HER-2 with
detection, metastasis, and prognosis of breast cancer. This study is aimed at
evaluating overexpression of HER2 as a prognostic factor in breast cancer with
sentinel lymph node metastases.
Methods: This is an analytic study with cross sectional research design.
Results: In this study, a sample of 51 people was obtained. Most types of breast
cancer are invasive ductal carcinoma in 40 patients (78.4%), then invasive no
other specific type in 7 patients (13.7%), then invasive lobular carcinoma and
DCIS in 2 patients (3.9%). From the results of statistical tests found no
relationship between overexpression of HER-2 with sentinel lymph node
metastases (p = 0.255). Patients who had HER2 expression had a 1.477 times
greater risk of having sentinel lymph node metastases compared to a group of
patients with no HER2 expression.
Conclusion: There is no relationship between HER-2 overexpression with the
occurrence of sentinel lymph node metastases.Kanker payudara merupakan keganasan pada jaringan payudara yang dapat
berasal dari epitel duktus maupun lobulusnya. Kanker payudara adalah kanker
yang paling sering ditemukan pada wanita, dengan angka insidensi 43,1 per
100.000 orang. Diperkirakan terdapat 1.671.149 kasus baru kanker payudara yang
terdiagnosis pada tahun 2012. Status kelenjar getah bening aksila telah menjadi
salah satu faktor prognostik terkuat pada wanita dengan kanker payudara stadium
awal. (Schröder et al., 2018) Diseksi kelenjar getah bening (ALND) telah lama
digunakan sebagai metode untuk mengidentifikasi metastasis kelenjar getah
bening aksila, dan saat ini sudah mulai digantikan dengan metode lain yang lebih
non-invasif yaitu biopsy kelenjar getah bening sentinel (SLNB). Biopsi kelenjar
getah bening sentinel merupakan suatu teknik invasif minimal yang dapat
mengkonfirmasi adanya metastasis kelenjar getah bening regional pada kanker.
(Nieweg, Uren, & Thompson, 2015) Biopsi kelenjar getah bening sentinel dapat
dilakukan dengan beberapa teknik mapping limfatik yaitu dengan mengunakan
blue-dye, radiotracer atau kombinasi keduanya.
Penelitian ini merupakan penelitian analitik dengan desain penelitian cross
sectional. Penelitian dilakukan di rumah sakit pendidikan FK USU. Sampel
penelitian ini adalah penderita kanker payudara yang memenuhi kriteria inklusi
dan eksklusi di rumah sakit pendidikan FK USU. Data yang sudah dikumpulkan,
diolah, dan dianalisis melaui statistik dan disajikan dalam bentuk tabel. Data
dianalisis dengan menggunakan uji chi square.
Berdasarkan penelitian ini, didapatkan jenis kanker terbanyak adalah invasive
ductal carcinoma. Secara histologi, ditemukan paling banyak kanker payudara
dengan grade 3. Ukuran tumor yang di dapatkan pada T2 dengan 40 pasien
(86,3%). Dari pemeriksaan immunohistokimia dan pemeriksaan sentinel biopsi
didapatkan bahwa tidak ada hubungan antara overexpression HER-2 dengan
terjadinya metastasis kelenjar getah bening sentinel (P > 0,05).Tesis Magiste
Clinicopathological Features of Young-Onset Breast Cancer Patients Based on Molecular Subtypes at H. Adam Malik Hospital
No full textIntroduction: Breast cancer is a major global health issue, and its incidence among young women (aged <40 years) is increasing. This study aims to analyze the clinicopathological features of young-onset breast cancer (YOBC) patients at H. Adam Malik Hospital, Medan, focusing on molecular subtypes and their association with clinical outcomes. YOBC tends to present with more aggressive disease and poorer prognosis than in older women, often showing higher grades and more advanced stages at diagnosis.
Methods: This descriptive observational study with a cross-sectional design reviewed medical records of breast cancer patients aged <40 years treated at H. Adam Malik Hospital from January 2017 to December 2022. Data on demographics, tumor characteristics, lymph node involvement, metastasis, histopathology, and molecular subtypes (Luminal A, Luminal B, HER-2 positive, and triple-negative breast cancer) were collected and analyzed descriptively.
Results: A total of 104 patients were included. The mean age was 35.8 years (SD 4.05), with a median age of 37 years. The majority of patients presented with advanced disease (stage IV: 51%), large tumors (T4: 69.2%), and significant lymph node involvement (N1: 55.8%). Invasive ductal carcinoma (IDC) was the most common histopathological type (46.2%), and poorly differentiated tumors (Grade III) were predominant (39.4%). The HER-2 positive molecular subtype was the most frequent (37.5%), followed by Luminal B (29.8%) and triple-negative (21.2%). Most cases had negative estrogen receptor (ER: 69.2%) and progesterone receptor (PR: 68.3%) expression, while HER-2 expression was positive in 59.6% of patients.
Conclusion: YOBC at H. Adam Malik Hospital is characterized by advanced-stage disease, aggressive histological features, and a predominance of HER-2 positive and Luminal B molecular subtypes. These findings emphasize the need for early detection and targeted therapeutic strategies in this population.97 PagesTesis Magiste
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