4,305 research outputs found
A PC parallel port button box provides millisecond response time accuracy under Linux
No full textFor psychologists, it is sometimes necessary to measure people's reaction times to the nearest millisecond. This article describes how to use the PC parallel port to receive signals from a button box to achieve millisecond response time accuracy. The workings of the parallel port, the corresponding port addresses, and a simple Linux program for controlling the port are described. A test of the speed and reliability of button box signal detection is reported. If the reader is moderately familiar with Linux, this article should provide sufficient instruction for him or her to build and test his or her own parallel port button box. This article also describes how the parallel port could be used to control an external apparatus
Twentieth-Century Varieties Reflecting Mediaeval Settlement in Normandy: combining modern and historical dialectology
No full textThe article demonstrates how the methods of modern dialectology can be used together with established dialectological and toponymic findings to inform our understanding of present-day variation. The linguistic data used are from the ‘Atlas
Linguistique et Ethnographique Normand’, whose data were collected in the 1970s, and in which many of the words given to researchers are probably Norman as opposed to French. The comparison of these data with the known settlement patterns
of Vikings in Normandy in the ninth to eleventh centuries shows clearly that the Vikings’ mediaeval settlement patterns are reflected in isoglosses which can be drawn based on the Atlas’ twentieth-century data, and the statistics of the modern
methods show how strong the correlation is
Millisecond accuracy video display using OpenGL under Linux
No full textTo measure people’s reaction times to the nearest millisecond, it is necessary to know exactly when
a stimulus is displayed. This article describes how to display stimuli with millisecond accuracy on a
normal CRT monitor, using a PC running Linux. A simple C program is presented to illustrate how this
may be done within X Windows using the OpenGL rendering system. A test of this system is reported
that demonstrates that stimuli may be consistently displayed with millisecond accuracy. An algorithm
is presented that allows the exact time of stimulus presentation to be deduced, even if there are relatively
large errors in measuring the display time
Frontmatter (Titlepage, Table of Contents, Author List, PC List, Reviewer List)
No full textFront matter including table of contents, author list, PC list, and reviewer list
Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.
No full textCopyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.PURPOSE: In spite of intense research efforts, pancreatic ductal adenocarcinoma remains one of the most deadly malignancies in the world. We and others have previously identified a subpopulation of pancreatic cancer stem cells within the tumor as a critical therapeutic target and additionally shown that the tumor stroma represents not only a restrictive barrier for successful drug delivery, but also serves as a paracrine niche for cancer stem cells. Therefore, we embarked on a large-scale investigation on the effects of combining chemotherapy, hedgehog pathway inhibition, and mTOR inhibition in a preclinical mouse model of pancreatic cancer. EXPERIMENTAL DESIGN: Prospective and randomized testing in a set of almost 200 subcutaneous and orthotopic implanted whole-tissue primary human tumor xenografts. RESULTS: The combined targeting of highly chemoresistant cancer stem cells as well as their more differentiated progenies, together with abrogation of the tumor microenvironment by targeting the stroma and enhancing tissue penetration of the chemotherapeutic agent translated into significantly prolonged survival in preclinical models of human pancreatic cancer. Most pronounced therapeutic effects were observed in gemcitabine-resistant patient-derived tumors. Intriguingly, the proposed triple therapy approach could be further enhanced by using a PEGylated formulation of gemcitabine, which significantly increased its bioavailability and tissue penetration, resulting in a further improved overall outcome. CONCLUSIONS: This multimodal therapeutic strategy should be further explored in the clinical setting as its success may eventually improve the poor prognosis of patients with pancreatic ductal adenocarcinoma
High efficiency implementation of PC and PC stable algorithms yields three-dimensional graphs of information flow for the Earth' atmosphere
No full textSeptember 3, 2014.Causal discovery algorithms have recently been applied to several climate applications. In particular, in prior work we have developed methods to recover pathways of interaction in the global climate system, using the classic PC algorithm. However, standard implementations of the PC algorithm cannot handle the large number of variables and temporal models required for this application. This technical report shows that a more efficient implementation of the PC algorithm can provide speed gains of a factor of 1,000 or more. This in turn enables us to calculate graphs of information flow with much higher resolution grids. Furthermore, we can now - for the first time ever - calculate information flow graphs that extend over three dimensions, i.e. rather than just including one layer of the planet's atmosphere we can now capture interactions across several height layers
Um simulador integrado pra laboratorios de computação
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoO uso de computadores para aprendizagem abre novas possibilidades no ensino de nível superior, possibilitando especialmente uma interação maior entre os alunos e as disciplinas de diferentes cursos. O presente trabalho implementa um simulador adequado para o ensino de graduação de cursos de computação nas áreas de hardware, como circuitos digitais, arquitetura de computadores e automação industrial. O simulador desenvolvido usa um ambiente único, onde é possível a simulação de sistemas híbridos compostos por dispositivos digitais e analógicos. Ao contrário de sistemas comerciais este simulador é aberto, permitindo a criação de componentes definidos pelo usuário e, adicionalmente proporciona a integração de equipamentos externos através de um interface de hardware e software. O próprio código é disponível, e pode servir como exemplo de programação de sistemas C, tal como, sistemas CAD e CAM
State variable simulation package for IBM-PC
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
Researchers can access this thesis by asking their local university, institution or public library to
make a request on their behalf. Monash staff and postgraduate students can use the link in the References field
Degradation of bisphenol-a-polycarbonate (BPA-PC) optical lenses under simulated harsh environment conditions
No full textThis paper investigates degradation and failure mechanisms of BPA-PC lenses in simulated harsh environment conditions. Exposure of secondary optics in Light Emitting Diode LED-based systems or any other similar applications to environmental stresses can adversely effect the performance and lifetime of products. This paper simulates a harsh environment condition, using a salt bath oven. Salt spray exposure/ageing tests at 45° C were carried out up to four months. Fourier transform infrared-attenuated total reflection FTIR-ATR spectrometer and Lambda 950 Ultraviolet-Visible (UV-VIS) spectrophotometer were used to study the optical and chemical characteristics of aged plates. Results showed that salt bath exposure test resulted in the severe deterioration of optical characteristics BPA-PC samples. Degradation of optical properties of BPA-PC plates is attributable to the oxidation of samples.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Components, Technology and Material
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