4,304 research outputs found
Erratum: 3D bioprinted in vitro secondary hyperoxaluria model by mimicking intestinal-oxalatemalabsorption-related kidney stone disease (Applied Physics Reviews (2022) 9 (041408) DOI: 10.1063/5.0087345)
No full text© 2023 Author(s).This article was originally published online on 21 November 2022 with an incorrect affiliation identifier for author Dong-Woo Cho. It is correct as it appears above. All online versions of this article were corrected on 23 November 2022. AIP Publishing apologizes for this error.11Nsciescopu
Unimodality of Betti numbers for Hamiltonian circle actions with index-increasing moment Maps
No full textThe unimodality conjecture posed by Tolman in [L. Jeffrey, T. Holm, Y. Karshon, E. Lerman and E. Meinrenken, Moment maps in various geometries, http://www.birs.ca/workshops/2005/05w5072/report05w5072.pdf] states that if (M,ω) is a 2n-dimensional smooth compact symplectic manifold equipped with a Hamiltonian circle action with only isolated fixed points, then the sequence of Betti numbers {b0(M),b2(M),...,b2n(M)} is unimodal, i.e. bi(M) ≤ bi+2(M) for every i < n. Recently, the author and Kim [Y. Cho and M. Kim, Unimodality of the Betti numbers for Hamiltonian circle action with isolated fixed points, Math. Res. Lett. 21(4) (2014) 691-696] proved that the unimodality holds in eight-dimensional case by using equivariant cohomology theory. In this paper, we generalize the idea in [Y. Cho and M. Kim, Unimodality of the Betti numbers for Hamiltonian circle action with isolated fixed points, Math. Res. Lett. 21(4) (2014) 691-696] to an arbitrary dimensional case. We prove the conjecture in arbitrary dimension under the assumption that the moment map H : M → R is index-increasing, which means that ind(p) < ind(q) implies H(p) < H(q) for every pair of critical points p and q of H, where ind(p) is the Morse index of p with respect to H. © World Scientific Publishing Company1111sciescopu
Systems biology for reverse aging
No full textCellular senescence is an irreversible and permanent cell cycle arrest in response to internal and external stresses. Its unresponsiveness to growth factor signals distinguishes it from a potentially reversible state, quiescence. Cellular senescence can inhibit tumor development by blocking proliferation of damaged cells, but as senescent cells become accumulated in a tissue, they can contribute to the promotion of agerelated diseases such as cancer by secreting inflammatory cytokines [1]. © 2021 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The antihypertensive effects of the Jamaican Cho-Cho (Sechium edule)
No full textThe experiments reported in this study constitute a preliminary investigation into the possible hypotensive effect of the Jamaican Cho-Cho (Sechium edule). Experiments were conducted in a random and blind fashion on two sub species of Sechium edule. Both the pulp and the peel were examined for hypotensive activity. Water-soluble extracts were prepared from these components of the fruit and injected into anaesthetised rats. Various cardiovascular parameters were measured including heart rate, mean arterial pressure (MAP) and several ECG intervals. We report that all extracts tested produced a fall in blood pressure with little change in ECG intervals. Extract B produced the least change in heart rate with a fall in MAP of approximately 23 mmHg. Changes in heart rate with all extracts appeared to be minimal as an ED25 value could only be determined for extract A, and ED10 values could not be evaluated for extracts C and D. The mechanism(s) by which these extracts produce their hypotensive effects could not be determined in these preliminary experiments. However, it appears not to involve direct effects on cardiac tissue. This conclusion is based on the finding that it took a minimum of 10 to 15 seconds for the hypotensive action to manifest post bolus. Future experiments will be aimed at delineating the mechanism(s) involved in decreasing MAP.Peer reviewedfinal article publishe
Nota su Eschilo, Cho. 65
No full textThe author defends the reading ἄκραντος in the sense of “unfinished” in Aesch. Cho. 65
The ticking clocks of Herman Melville
No full textHerman Melville lived to see the world around him transform from the old ways to the new during the mid 19th century. While innovations in technology, labor and economy are commonly credited to this period, the reliance on mechanical time was arguably just as influential. During this period, Melville was faced with a time that favored the clock over the measurements of the sun. This thesis argues that in "Bartleby, the Scrivener" and "The Paradise of Bachelors, and the Tartarus of Maids," Melville was struggling with the evolving publishing industry and the changing world around him
The ticking clocks of Herman Melville
No full textHerman Melville lived to see the world around him transform from the old ways to the\ud
new during the mid 19th century. While innovations in technology, labor and economy\ud
are commonly credited to this period, the reliance on mechanical time was arguably just\ud
as influential. During this period, Melville was faced with a time that favored the clock\ud
over the measurements of the sun. This thesis argues that in ???Bartleby, the Scrivener???\ud
and ???The Paradise of Bachelors, and the Tartarus of Maids,??? Melville was struggling with\ud
the evolving publishing industry and the changing world around him
Lathrobium sinense HERMAN 2003
No full textLathrobium sinense HERMAN, 2003 Material examined: Japan: 1 , 1 [both brachypterous], Hokkaido, Kaihatsu-cho-minami, 15 m, 25. VII.1991, leg. Smetana [J7] (CNC, cAss); 1 , Honshu, Toshigi Pref., Nikko National Park, Senjogahara, 1400 m, 15. VII.1980, leg. A. & Z. Smetana (CNC). Comment: This widespread wing-dimorphic species was previously known from numerous localities in China and one (Senjogahara) in Honshu (ASSING 2013f). The above specimens from Hokkaido represent a new island record.Published as part of Assing, Volker, 2015, New species and additional records of Lathrobium and Elytrobium from the Palaearctic region, with special reference to the fauna of East Yunnan (Coleoptera: Staphylinidae: Paederinae), pp. 41-74 in Beiträge Zur Entomologie = Contributions to Entomology 65 (1) on page 66, DOI: 10.21248/contrib.entomol.65.1.41-74, http://zenodo.org/record/475388
An ‘omics approach towards CHO cell engineering
No full textBiotechnology and Bioengineering, 110, 1255–1271Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial production of biopharmaceutical products, such as monoclonal antibodies, human growth hormones, cytokines, and blood-products. Recent advances in recombinant DNA technology have resulted in the bioengineering of CHO cells that have robust gene amplification systems and can also be adapted to grow in suspension cultures. In parallel, recent advances in techniques and tools for decoding the CHO cell genome, transcriptome, proteome, and glycome have led to new areas of study for better understanding the metabolic pathways in CHO cells with the long-term goal of developing new biologics. This review paper discusses the recent advances in bioengineering strategies in CHO cell lines and the impact of the knowledge gained by CHO cell genomics, transcriptomics, and glycomics on the future of CHO-cell engineering.National Institute of General Medical Scienceshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1002/bit.2484
Considering spurious timeout in proxy for improving TCP performance in wireless networks
No full textIn this paper, we introduce a new proxy that effectively prevents unnecessary retransmissions of Transmission Control Protocol data segments from flowing over a wireless link on a path with sudden delay. The proposed Spurious Timeout Detection (STD) algorithm detects spurious timeout based on the data and acknowledge sequence number. It responses to spurious timeout by filtering unnecessary data transmissions that can cause spurious fast retransmission. Simulation result shows that proposed STD algorithm performs better than, or as well as, other end-to-end mechanisms in a certain range of data rate. (C) 2003 Published by Elsevier B.V.
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