842 research outputs found
Letter from Karl I. Zimmerman and T.R. Martinez to Toshiko Chuman
No full textA letter to Toshiko Chuman (nee Nakamura) from Karl I. Zimmerman, District Director of Immigration and Naturalization Service (INS) in Philadelphia, and T.R. Martinez, Acting Chief, Detention, Deportation and Parole Section. The letter regards his release from INS into the custody of her attorney, Wayne M. Collins.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
Letter from Karl I. Zimmerman and T.R. Martinez to Hayao (Sam) Chuman
No full textA letter to Hayao (Sam) Chuman from Karl I. Zimmerman, District Director of Immigration and Naturalization Service (INS) in Philadelphia, and T.R. Martinez, Acting Chief, Detention, Deportation and Parole Section. The letter regards his release from INS into the custody of his attorney, Wayne M. Collins.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
The beta c receptor family - Structural insights and their functional implications
No full textAbstract not availableSophie E. Broughton, Tracy L. Nero, Urmi Dhagat, Winnie L. Kan, Timothy R. Hercus, Denis Tvorogov, Angel F. Lopez, Michael W. Parke
Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling
No full textAbstract not availableSophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Mara Dottore, Barbara J. McClure, Urmi Dhagat, Houng Taing, Michael A. Gorman, Jack King-Scott, Angel F. Lopez, Michael W. Parke
Messing with beta c: a unique receptor with many goals
No full textOur understanding of the biological role of the βc family of cytokines has evolved enormously since their initial identification as bone marrow colony stimulating factors in the 1960's. It has become abundantly clear over the intervening decades that this family of cytokines has truly astonishing pleiotropic capacity, capable of regulating not only hematopoiesis but also many other normal and pathological processes such as development, inflammation, allergy and cancer. As noted in the current pandemic, βc cytokines contribute to the cytokine storm seen in acutely ill COVID-19 patients. Ongoing studies to discover how these cytokines activate their receptor are revealing insights into the fundamental mechanisms that give rise to cytokine pleiotropy and are providing tantalizing glimpses of how discrete signaling pathways may be dissected for activation with novel ligands for therapeutic benefit.Winnie L. Kan, Karen S. Cheung Tung Shing, Tracy L. Nero, Timothy R. Hercus, Denis Tvorogov, Michael W. Parker, Angel F. Lope
On the origins of Cyprideis torosa (Jones, 1850) and a short biography of Professor T.R. Jones
No full textThe original description and taxonomic attribution of Cyprideis torosa (Jones, 1850) is reviewed with reference to the type locality at Grays, Essex, SE England and several of the original specimens are re-illustrated. A short biography of its author, the geologist T.R. Jones, is provided
Season 10 Episode 11: Healthcare Around the World
No full textFans of U.S. health care reform point out that many other countries provide coverage for all their citizens, and no one files for bankruptcy due to medical bills. But how exactly do these countries do it? January Series guest & journalist T.R. Reid, author of The Healing of America: A Global Quest for Better, Cheaper, and Fairer Health Care, tells of his travels comparing systems around the world. Shirley Hoogstra hosts. Episode #1011
On the origins of Cyprideis torosa (Jones, 1850) and a short biography of Professor T.R. Jones
No full textThe original description and taxonomic attribution of Cyprideis torosa (Jones, 1850) is reviewed with reference to the type locality at Grays, Essex, SE England and several of the original specimens are re-illustrated. A short biography of its author, the geologist T.R. Jones, is provided
Translating the biology of B common receptor-engaging cytokines into clinical medicine
No full textThe family of cytokines that comprises IL-3, IL-5, and GM-CSF was discovered over 30 years ago, and their biological activities and resulting impact in clinical medicine has continued to expand ever since. Originally identified as bone marrow growth factors capable of acting on hemopoietic progenitor cells to induce their proliferation and differentiation into mature blood cells, these cytokines are also recognized as key mediators of inflammation and the pathobiology of diverse immunologic diseases. This increased understanding of the functional repertoire of IL-3, IL-5, and GM-CSF has led to an explosion of interest in modulating their functions for clinical management. Key to the successful clinical translation of this knowledge is the recognition that these cytokines act by engaging distinct dimeric receptors and that they share a common signaling subunit called β-common or βc. The structural determination of how IL-3, IL-5, and GM-CSF interact with their receptors and linking this to their differential biological functions on effector cells has unveiled new paradigms of cell signaling. This knowledge has paved the way for novel mAbs and other molecules as selective or pan inhibitors for use in different clinical settings.Harshita Pant, Timothy R. Hercus, Damon J. Tumes, Kwok Ho Yip, Michael W. Parker, Catherine M. Owczarek, Angel F. Lopez, and David P. Husto
Gender dynamics in data collection on reproductive health: field experiences in Kerala, India
No full textReproductive health researchers tend to choose interviewers of the same sex as those interviewed. In many societies, it is considered unacceptable for men to interview women on topics of an intensely personal nature like sexuality or contraceptive use. In this paper, the author analyzes 21 interviews and 16 focus group discussions (FGDs) undertaken during a field study on the Quality of Services in the Indian Family Welfare Programs conducted in Kerala. The analysis was based on the model which identifies the principal participants in the interview as the respondent and the interviewer. In all these cases the contradiction between the gendered roles of the interviewer and interviewee are visible. However, if viewed in the context of the model provided by Briggs, it is clear that these contradictions are due to the differences in the social roles that the interviewers assumed and that the respondents ascribed to them and in the interactional goals of the interviewers and the respondents. Contradictions were also experienced during the FGDs. Educational sessions on contraception are a good tool for gathering sensitive information instead of the conventional interview, where the gendered roles are so crucial to the information gathering exercise itself
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