163,859 research outputs found
The animal suffering
No full textHepp J. La souffrance animale. In: Bulletin de l'Académie Vétérinaire de France tome 130 n°4, 1977. pp. 469-474
Le pharmacien Eugène-Emile Hepp (1819-1871) : J. Heran, Il y a 150 ans : le rapport de Persoz sur l'étudiant Hepp
No full textLabrude Pierre. Le pharmacien Eugène-Emile Hepp (1819-1871) : J. Heran, Il y a 150 ans : le rapport de Persoz sur l'étudiant Hepp. In: Revue d'histoire de la pharmacie, 82ᵉ année, n°300, 1994. p. 110
Kontrastive Textologie
No full textDie kontrastive Textologie führt sprach- und kulturvergleichende Analysen nach empirischen Kriterien aus. Gegenstand der Analyse sind Texte, die unterschiedliche Kulturen unter vergleichbaren kommunikativen Rahmenbedingungen widerspiegeln. Der Aufsatz zeigt, wie Leseförderkonzepte entwickelt werden können, die auf dem Vergleich von parallelen Textexemplaren in unterschiedlichen Kulturen gründen
Morphologie: Komposition und Derivation
No full textBetrachtungsweise der Wortbildung (WB) durch die kognitive Linguistik: Die Bedeutung der WB kann einerseits durch die Analyse des jeweiligen Wortbildungsverfahrens (Motivierung und Transparenz), andererseits durch den Einbezug des Kontexts erschlossen werden. Die verbindung der beiden betrachtungsansätze präzisiert die Bedeutungsfestlegung
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Industry Dynamics during Times of Disruption: Essays on Technological Regimes and a Pandemic from a Complex System Perspective
No full textHepp J. Industry Dynamics during Times of Disruption: Essays on Technological Regimes and a Pandemic from a Complex System Perspective. Bielefeld: Universität Bielefeld; 2022
Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels
No full textThe cytosolic redox status modulates ion channels and receptors by oxidizing/ reducing their sulfhydryl ( SH) groups. We therefore analyzed to what degree SH modulation affects hippocampal susceptibility to hypoxia. In rat hippocampal slices, severe hypoxia caused a massive depolarization of CA1 neurons and a negative shift of the extracellular DC potential, the characteristic sign of hypoxia- induced spreading depression ( HSD). Oxidizing SH groups by 5,5 '- dithiobis 2- nitrobenzoic acid ( DTNB, 2 mM) postponed HSD by 30%, whereas their reduction by 1,4- dithio- DL- threitol ( DTT, 2 mM) or alkylation by N- ethylmaleimide ( 500 mu M) hastened HSD onset. The DTNB- induced postponement of HSD was not affected by tolbutamide ( 200 mu M), DL- 2- amino- 5-phosphonovaleric acid ( 150 mu M), or 6- cyano- 7- nitroquinoxaline- 2,3-dione ( 25 mu M). It was abolished, however, by Ni2+ ( 2 mM), withdrawal of extracellular Ca2+, charybdotoxin ( 25 nM), and iberiotoxin ( 50 nM). In CA1 neurons DTNB induced a moderate hyperpolarization, blocked spontaneous spike discharges and postponed the massive hypoxic depolarization. DTT induced burst firing, depolarized glial cells, and hastened the onset of the massive hypoxic depolarization. Schaffer- collateral/ CA1 synapses were blocked by DTT but not by DTNB; axonal conduction remained intact. Mitochondria did not markedly respond to DTNB or DTT. While the targets of DTT are less clear, the postponement of HSD by DTNB indicates that sulfhydryl oxidation increases the tolerance of hippocampal tissue slices against hypoxia. We identified as the underlying mechanism the activation of BK channels in a Ca2+- sensitive manner. Accordingly, ionic disregulation and the loss of membrane potential occur later or might even be prevented during short- term insults. Therefore well- directed oxidation of SH groups could mediate neuroprotection
Textstruktur und sprachliche Merkmale in Referaten italienischer Germanistikstudenten
No full textÜberlegungen zu einer zwischen Mündlichkeit und Schriftlichkeit anzusiedelnden Textsorte oder Diskursart, dem Referat, wobei insbesondere auf den italienischen universitären DaF-Kontext Bezug genommen wird. Grundlage der Analyse bildet ein Korpus von Referaten italienischer Germanistikstudenten aus dem ersten Jahr des zweijährigen Masterstudiengangs für europäische und amerikanische Sprach- und Literaturwissenschaften an einer italienischen Universität
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