5,698 research outputs found
SC author and illustrator Kate Salley Palmer signing book
No full textPhotograph of SC author and illustrator Kate Salley Palmer signing boo
Book signing by SC author and illustrator Kate Salley Palmer
No full textPhotograph of Book signing by SC author and illustrator Kate Salley Palme
High-resolution clean-sc
No full textIn this paper a high-resolution extension of CLEAN-SC is proposed: HR-CLEAN-SC. Where CLEAN-SC uses peak sources in “dirty maps” to define so-called source components, HR-CLEAN-SC takes advantage of the fact that source components can likewise be derived from points at some distance from the peak, as long as these “source markers” are on the main lobe of the Point Spread Function (PSF). This is very useful when sources are closely spaced together, such that their PSFs interfere. Then, alternative markers can be sought in which the relative influence by PSFs of other source positions is minimised. For those markers the source components better agree with the actual sources, which allows for better estimation of their locations and strengths. This paper outlines the theory needed to understand this approach and discusses applications to 2D and 3D microphone array simulations with closely spaced sources
SC author and illustrator Kate Salley Palmer talking to event attendees
No full textPhotograph of SC author and illustrator Kate Salley Palmer talking to Rita Lewi
Ca-modified Al–Mg–Sc alloy with high strength at elevated temperatures due to a hierarchical microstructure
No full textAl-Mg alloys are normally prone to lose part of their yield and tensile strength at high temperatures due to insufficient thermal stability of the microstructure. Here, we present a Ca-modified Al–Mg–Sc alloy demonstrating high strength at elevated temperatures. The microstructure contains Al4Ca phases distributed as a network along the grain boundary and Al3(Sc,Zr) nano-particles dispersed within the grains. The microstructure evolution and age-hardening analysis indicate that the combination of an Al4Ca network and Sc-rich nano-particles leads to excellent thermal stability even upon aging at 300 °C. The tensile strength of the alloy for temperatures up to 250 °C is significantly improved by an aging treatment and is comparable with the commercial heat-resistant aluminum alloys, i.e., A356 and A319. At a high temperature of 300 °C, the tensile strength is superior to the above-mentioned commercial alloys, even more so when expressed as the specific strength due to the low density of Ca-modified Al–Mg–Sc alloy. The excellent high-temperature strength results from a synergistic effect of solid solution strengthening, grain boundary strengthening and nanoparticle order strengthening.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Novel Aerospace Material
SC-Square: Overview to 2021.
No full textThis extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights
SC-Square: Overview to 2021.
No full textThis extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights
Subcutaneous Trastuzumab: A Review in HER2-Positive Breast Cancer
No full textCompliance with Ethical Standards Disclosure: The preparation of this review was
not supported by any external funding.
Conflicts of interest: Young-A Heo and Yahiya Syed are salaried employees of Adis/Springer, are responsible for the article
content and declare no relevant conflicts of interest. Additional information about this
Adis Drug Review can be found hereAbstractA subcutaneous (SC) formulation of trastuzumab, a potent humanized anti-Human Epidermal growth factor Receptor 2 (HER2)
receptor monoclonal antibody, with a recombinant hyaluronidase (Herceptin Hylecta™; Herceptin®) is indicated in the USA
and EU for the treatment of HER2-positive breast cancer. In the phase III pivotal HannaH trial, SC trastuzumab was noninferior
to the standard intravenous (IV) formulation of trastuzumab with respect to trough drug concentrations and pathological complete response in patients with HER2-positive early breast cancer. Other clinical outcomes, including event-free survival and
overall survival rates, were generally similar between the formulation groups. SC trastuzumab had a manageable tolerability
profle in patients with HER2-positive early or metastatic breast cancer, with the safety profle being generally similar to that
of the IV formulation. In the phase III PrefHER and MetaspHER trials, more patients preferred SC over IV trastuzumab and
more healthcare professionals expressed satisfaction with the SC formulation. Relative to IV trastuzumab, SC trastuzumab
ofers a quicker and more convenient dosage regimen, thereby potentially improving patient convenience, providing economic
beneft and optimizing the use of medical resources. Thus, given the high preference for SC trastuzumab and its generally
similar efcacy and tolerability profle to that of the IV formulation, SC trastuzumab is the preferred treatment of choice in
patients receiving trastuzumab for the treatment of HER2-positive early or metastatic breast cancer.© Springer Nature Switzerland AG 2019
</p
Supply Chain (SC) Network Optimization
No full textSupply chain network design and optimization is one of the most important strategic decisions that an organization has to make. SC network design decisions are strategic-level SC decisions because they have long-lasting effect on the firms' supply chain performance and the decisions cannot be changed in a short period. In this chapter, the author aims to introduce the concept of SC network optimization to the managers of medium-sized enterprises. The chapter also explains the importance of the SC network optimization studies, educates readers about how they can benefit from the concept, and tries to show how the implementation of SC network optimization/design will improve the competitiveness of these organizations. The readers are also guided through the four steps of SC network optimization process. Finally, the chapter provides a brief review of the SC network optimization literature and proposes future research directions. </jats:p
The turbulence structure of 3D separation (Stall Cells) over an airfoil
No full textThe flow over airfoils that experience separation of the trailing edge type becomes three-dimensional at angles of attack around maximum lift and Stall Cells (SCs) form. SCs are large scale coherent structures of separated flow that consist of two counter-rotating vortices. In the present study the turbulence structure of a SC over a rectangular wing is investigated using Stereo PIV measurements. It is found that the turbulence characteristics of the flow are highly anisotropic and that the Boussinesq approximation is invalid. High values of normal Reynolds stresses in the SC vortices and the separation shear layer region indicates a wandering motion of the former and a flapping motion of the latter. Based on the available data the relation between Reynolds stresses, their production terms and the mean flow gradients is examined. It is found that at the centre of the SC, between the two vortices, the flow characteristics resemble those of a double shear layer while at the vortex region the effect of the vortices leads to double peaks in production terms
- …
