350 research outputs found
Testimony of Henry Erlich
No full textErlich was a witness for the defense and Chair of the Human Genetics Department at Cetus Corporation. He testified on February 13th and 14th
Sounds Local, 1998 March 21
No full textInterview with author Margot Adler about her novel, Heretic's Heart: A Journey through Spirit and Revolution, and her life as an activist and student at Berkeley; Reese Erlich reports on a cappella and jazz groups Oakland's SoVoSo and Boston's Vox One; Man in the Iron Mask (film) review by WHQR's film commentator, Steve Taylor; Overview of upcoming events on the cultural calendar
The Influence of American Anthropology on the Work of Vera Stein Erlich
No full textBoravak i studij kulturne antropologije u SAD veoma je utjecao na rad Vere Erlich. Prvobitno zanimanje za psihologiju porodice i obrazovanja i za položaj žene u patrijarhalnom društvu preusmjerila je na antropološku analizu promjena u patrijarhalnom društvu i porodici. Na njezino novo znanstveno usmjerenje najviše su utjecali kulturni antropolozi Kroeber i Redfield, kao i pripadnici smjera »kultura i ličnost«. Poput sljedbenika te antropološke tradicije, Vera Erlich nailazila je također na poteškoće u objašnjavaju unutarnje dinamike promjena u patrijarhalnom društvu. Definiravši ga kao društvo koje živi po principu moralnog integriteta, reda i koherentnosti, sve potrese i promjene tog reda morala je pripisati »vanjskim faktorima«.Living and studying anthropology in Berkeley in the 1950's and the 1960's had a profound effect on Vera Erlich's scientific orientation. Her primary interest in psychology, education and the status of women shifted towards the anthropological analysis of changes in patriarchal family and society. The most natural theoretical link between the two phases of her intellectual development was the "culture and personality” school which at that time dominated American anthropology.
In this article, by analyzing two major Erlich’s books (Family in Transition, Princeton 1966; and In the Company of Man, Zagreb 1968), the author traces the theoretical influence of Kroeber, Benedict, Mead, Redfield and some others on Vera Erlich’s concepts of culture, cultural style, mentality, patriarchal society etc.
In conclusion, it is pointed out that Vera Erlich could not resolve the contradiction of stability vs. change in patriarchal cultural order. While explaining stability by "inner factors’ of coherence, moral integrity and order, she attributed cultural change to "outside factors" — such as emancipation from the rule of Turks in South Slay areas. The problem is shared by "culture and personality" tradition in general, since it cannot account for the dynamics and contradictions of culture except at the level of the socialization of individual
HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infections
No full textOne of the mechanisms by which viruses can evade the host’s immune system is to modify the host’s DNA methylation pattern. This work aims to investigate the DNA methylation and gene expression profile of COVID-19 patients, divided into symptomatic and asymptomatic, and healthy controls, focusing on genes involved in the immune response. In this study, changes in the methylome of COVID-19 patients’ upper airways cells, the first barrier against respiratory infections and the first cells presenting viral antigens, are shown for the first time. Our results showed alterations in the methylation pattern of genes encoding proteins implicated in the response against pathogens, in particular the HLA-C gene, also important for the T-cell mediated memory response. HLA-C expression significantly decreases in COVID-19 patients, especially in those with a more severe prognosis and without other possibly confounding co-morbidities. Moreover, our bionformatic analysis revealed that the identified methylation alteration overlaps with enhancers regulating HLA-C expression, suggesting an additional mechanism exploited by SARS-CoV-2 to inhibit this fundamental player in the host’s immune response. HLA-C could therefore represent both a prognostic marker and an excellent therapeutic target, also suggesting a preventive intervention that conjugate a virus-specific antigenic stimulation with an adjuvant increasing the T-cell mediated memory response
Association of CTLA-4 variation with type I diabetes in Filipinos
No full textThe role of non-HLA single nucleotide polymorphisms from a panel of candidate genes in genetic susceptibility to type I diabetes (TID) among Filipinos was examined by PCR/SSOP typing of 90 patients and 94 controls, previously typed for the HLA class I and class II loci. We report the association of CTLA-4 A49G variation (cytotoxic T-lymphocyte associated-4) to TID among Filipinos, consistent with some but not all previous reports in other ethnic groups. The G allele frequency (0.61 versus 0.45, P=0.003) and GG genotype frequency (0.42 versus 0.22, P=0.004) were each increased in patients compared to controls, respectively. Among Filipinos, the CTLA-4 genotypes are associated with disease only in the presence of the predisposing DR3, 4, and 9 haplotypes (P=0.012). Compared to the AA genotype, the increased risk of diabetes predisposition is greatest in genotype GG bearing the DR susceptible alleles (DR3, 4, and 9) (odds ratio=4.6, P=0.001), demonstrating that non-HLA loci, acting in concert with HLA, can play potent roles in modifying susceptibility to TID
Mother-activist: the interwar autobiography of Sofia Dubnow-Erlich
No full textTematem artykułu jest studium przypadku – analiza fragmentów autobiografii Sofii Dubnow-Erlich dotyczących okresu międzywojennego. Bliższe spojrzenie na teksty autobiograficzne autorstwa związanej z Bundem aktywistki i literatki umożliwia prześledzenie jej podejścia do własnych planów życiowych, a także szerszy ogląd żydowskiej historii aktywizmu, działalności intelektualnej i politycznej w II Rzeczypospolitej. Lektura wspomnień pozwala również uchwycić perspektywę genderową i pokazać, czy i w jakim stopniu płeć kulturowa wpływała na podejmowane przez autorkę działania.The subject of this article is a case study based on analysis of Sofia Dubnow-Erlich’s autobiography fragments concerning the interwar period. A closer look at the autobiographical texts written by the activist and writer associated with the Bund allows to trace her approach to her own life plans. It also gives a broader look at the Jewish history of activism, and intellectual and political activity in the Second Polish Republic. Reading the memoirs allows us to capture the gender perspective and shows whether and to what extent the gender influenced the actions taken by the author
Homozygosity for the Ala allele of the PPARγ2 Pro12Ala polymorphism is associated with reduced risk of coronary artery disease.
No full textSeveral studies suggest that the peroxisome proliferator-activated receptor gamma (PPAR gamma) is involved in atherogenesis. The Pro12Ala polymorphism in the gene encoding PPAR gamma (PPAR gamma 2gene) influences the risk for type 2 diabetes. Two population-based studies have shown that the Ala allele is associated with reduced carotid intimal-medial thickness (IMT). However, studies focusing on acute clinical events have yielded conflicting results. Our aim was to evaluate the role of the Pro12Ala PPAR gamma 2 polymorphism on the risk of coronary artery disease (CAD) in an Italian population with a case-controlled genetic association study in which 478 CAD patients and 218 controls were genotyped for the Pro12Ala polymorphism. CAD was diagnosed by angiography. We found that homozygotes for the Ala12 allele had a significantly reduced risk of CAD after adjusting for diabetes, sex, age, body mass index (BMI), smoking, lipids and hypertension (OR = 0.007; 95% C. I. = 0.00-0.32 p < 0.011). In this case-control study, homozygosity for the Ala allele at codon 12 of the PPAR gamma 2 gene resulted in reduced risk of CAD. This is consistent with reports from previous studies focusing on atherosclerosis and myocardial infarction
Author´s response :
No full textThe mitochondrial hypervariable regions I and II have proven to be a useful target for analysis of forensic materials, in which the amount of DNA is limited or highly degraded. Conventional mitochondrial DNA (mtDNA) sequencing can be time-consuming and expensive, limitations that can be minimized using a faster and less expensive typing assay.We have evaluated the exclusion capacity of the linear array mtDNA HVI/HVII region-sequence typing assay (Roche Applied Science) in 16 forensic cases comprising 90 samples. Using the HVI/HVII mtDNA linear array, 56% of the samples were excluded and thus less than half of the samples require further sequencing due to a match or inconclusive results. Of all the samples that were excluded by sequence analysis, 79% could be excluded using the HVI/HVII linear array alone. Using the HVI/HVII mtDNA linear array assay, we demonstrate the potential to decrease sequencing efforts substantially and thereby reduce the cost and the turn-around time in casework analysis.</p
Meson Condensation and Holographic QCD
No full textQuantum Chromodynamics (QCD), which describes the strong nuclear force, is difficult to solve both analytically and numerically. We use a five-dimensional model of QCD motivated by the Anti-de Sitter/Conformal Field Theory (AdS/CFT) duality originally proposed by Maldacena. We discuss how this model and other variations in the literature represent chiral symmetry breaking, and test whether these models correctly reproduce chiral symmetry beyond leading order. We compare the predictions of two models, one which is correct to leading order, and another which is correct beyond leading order. The model correct to leading order does not properly predict the pion condensation phase transition, whereas the model with the correct beyond leading order qualitatively agrees with chiral perturbation theory in its description of pion condensation. Using these two models, we calculate certain observables and find agreement with experiment to within 15%
Generalizing Holographic Superconductors
No full textWe consider a family of holographically dual models of superconductivity to test the robustness of holographic superconductor models in general. Following the treatment of Hartnoll et al. and
Albrecht et al., we introduce the basic holographic model and then
develop a family of similar models by varying a parameter in the
spacetime metric of the holographic theory. We then calculate several observables and compare with actual superconductor observables. This helps determine whether these holographic models actually explain superconductivity or if the agreement between the
theories and experiment is a coincidence
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