192,241 research outputs found
Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein
Get PDFThe regulation of differentiation is particularly important in microbial eukaryotes that inhabit multiple environments. The parasite Trypanosoma brucei is an extreme example of this, requiring exquisite gene regulation during transmission from mammals to the tsetse fly vector. Unusually, trypanosomes rely almost exclusively on post-transcriptional mechanisms for regulated gene expression. Hence, RNA binding proteins are potentially of great significance in controlling stage-regulated processes. We have previously identified TbZFP1 as a trypanosome molecule transiently enriched during differentiation to tsetse midgut procyclic forms. This small protein (101 amino acids) contains the unusual CCCH zinc finger, an RNA binding motif. Here, we show that genetic ablation of TbZFP1 compromises repositioning of the mitochondrial genome, a specific event in the strictly regulated differentiation programme. Despite this, other events that occur both before and after this remain intact. Significantly, this phenotype correlates with the TbZFP1 expression profile during differentiation. This is the first genetic disruption of a developmental regulator in T. brucei. It demonstrates that programmed events in parasite development can be uncoupled at the molecular level. It also further supports the importance of CCCH proteins in key aspects of trypanosome cell function
Share your story: Intensive exposure treatment for adult and adolescent complex posttraumatic stress disorder
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208564.pdf (Publisher’s version ) (Open Access)Radboud University, 08 november 2019Promotores : Minnen, A. van, Becker, E.S. Co-promotor : Hendriks, G.J.177 p
Datasets for "Pulsational pair-instability supernovae in gravitational-wave and electromagnetic transients" from Hendriks et al 2023.
No full text<p>Data related to the paper "Pulsational pair-instability supernovae in gravitational-wave and electromagnetic transients" by Hendriks et al 2023 <a href="https://doi.org/10.1093/mnras/stad2857">https://doi.org/10.1093/mnras/stad2857</a>.</p><ul><li>`EVENTS_V2.2.2_SEMI_HIGH_RES*.tar.gz: main PPISN prescription variation simulation results for the GW mergers. These contain configurations for the populations and the convolved merger results which in turn contain merger rates, merger properties and events that preceded the mergers (RLOF episodes, SNe). These results are used in figures 2, 3, 6, and 7. Figure 8 uses the SFR used in one of these simulations.</li><li>`EVENTS_V2.2.2_MID_RES*.tar.gz`: PPISNe prescription variation results for the transient rate evolution. These contain configurations for the populations and the convolved merger results which in turn contain merger rates, merger properties and events that preceded the mergers (RLOF episodes, SNe). These results are used in figure 4.</li><li>`grid_single_mass_metallicity_data.tar.gz`: data containing single-star remnant-mass data as a function of initial mass vs. final mass for our fiducial model and three variations: Farmer 2019 PPISN prescription, M_extra_ppisn_ML=10 Msun (i.e. where 10 solarmass of additional mass loss occur for each PPISN), M_co_shift_ppisn=-5 Msun (i.e. the CO core mass range that undergoes PPISN is shifted to lower masses by 5 solarmass). This data is used in figure 5.</li><li>`schematic_overview_data.tar.gz`: data containing single-star remnant-mass data as a function of pre-SN core mass for our fiducial models and several variations: Farmer 2019 PPISN prescription, M_extra_ppisn_ML = 5 Msun, M_co_shift_ppisn=-5 Msun, M_co_shift_ppisn=+5 Msun. This data is used in figure 1.</li><li>`paper_ppisne_scripts-main.tar.gz`: git-repository that contains the routines to generate the figures. The readme in this script should contain enough information, but relevant to the data here: the user needs to store the files contained in this zenodo repository in a directory that they point to at with an environment variable called `paper_PPISNe_Hendriks2023_data_dir`. These scripts are also hosted on <a href="https://gitlab.com/dhendriks/paper_ppisne_scripts">https://gitlab.com/dhendriks/paper_ppisne_scripts</a></li></ul>
Connecting the dots in integrated water management : a critical analysis of a tangled concept
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107671.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 30 mei 2013Promotores : Hendriks, A.J., Keulartz, F.W.J. Co-promotor : Lenders, H.J.R.222 p
Diffuse gliomas: exploiting molecular and metabolic characteristics for improved diagnosis and therapy
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141392.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 15 juni 2015Promotor : Wesseling, P. Co-promotores : Leenders, W.P.J., Hendriks, W.J.A.J
Diabetes and anastomotic healing in the intestine. An experimental study.
No full textItem does not contain fulltextKatholieke Universiteit Nijmegen, 10 december 1999Promotores : Wobbes, T., Hendriks, T.185 p
Fate and effects of ionisable organic compounds and nanoparticles: At the interface of theory and experimentation
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200106.pdf (Publisher’s version ) (Closed access)Radboud University, 28 maart 2018Promotores : Ragas, A.M.J., Hendriks, A.J.305 p
The biological role of the receptor-like protein tyrosine phosphatase LAR
No full textItem does not contain fulltextCell Biology, 07 oktober 1997Promotor : Wieringa, B. Co-promotor : Hendriks, W.J.A.J.166 p
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