1,721,062 research outputs found
The complexity of walking. Cognitive control of gait in aging and Parkinson's disease
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176480.pdf (Publisher’s version ) (Open Access)Radboud University, 27 oktober 2017Promotores : Olde Rikkert, M.G.M., Bloem, B.R. Co-promotores : Reelick, M.F., Helmich, R.C.G
Molecular, structural, and behavioral differences between tremor dominant and non-tremor Parkinson’s disease
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219332.pdf (Publisher’s version ) (Open Access)Radboud University, 23 juni 2020Promotores : Cools, R., Toni, I.
Co-promotores : Helmich, R.C.G., Ouden, H.E.M. de
The distributed somatotopy of tremor: a window into the motor system
No full textItem does not contain fulltextThe posterior ventrolateral thalamus (VLp) plays a crucial role in Parkinson's tremor and in essential tremor: deep brain stimulation (DBS) of the VLp effectively diminishes both tremor types. Previous research has shown tremor oscillations in the VLp, but the spatial extent and somatotopy of these oscillations remained unclear. In this issue of Experimental Neurology, Pedrosa and colleagues measured neuro-muscular coherence at multiple sites in the VLp of patients with essential tremor and Parkinson's disease using implanted DBS electrodes (Pedrosa et al., 2012). They found multiple tremor clusters within the VLp, with spatially distinct tremor clusters for antagonistic muscles, and in many patients also multiple distinct tremor clusters for a single muscle. Interestingly, this group previously showed similar effects for the STN in tremulous Parkinson's disease (Reck et al., 2009, 2010). Together, these studies suggest that the distribution of tremor clusters is a general organizational principle of tremor, being present in two different tremor pathologies, and in two different nodes of the motor system. The presence of multiple tremor clusters also fits with the distributed somatotopy of the healthy motor system. Therefore, a further conclusion of this study could be that tremor is caused by aberrant synchronization within an otherwise healthy network, brought about by different pathophysiological neural triggers
Cerebral reorganization in Parkinson's disease.
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87164.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 24 mei 2011Promotor : Bloem, B.R. Co-promotor : Toni, I.317 p
The Cerebral Basis of Parkinsonian Tremor: A Network Perspective
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Author response: The nature of postural tremor in Parkinson disease
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Pathophysiology and Management of Parkinsonian Tremor
No full textParkinson's tremor is one of the cardinal motor symptoms of Parkinson's disease. The pathophysiology of Parkinson's tremor is different from that of other motor symptoms such as bradykinesia and rigidity. In this review, the authors discuss evidence suggesting that tremor is a network disorder that arises from distinct pathophysiological changes in the basal ganglia and in the cerebellothalamocortical circuit. They also discuss how interventions in this circuitry, for example, deep brain surgery and noninvasive brain stimulation, can modulate or even treat tremor. Future research may focus on understanding sources for the large variability between patients in terms of treatment response, on understanding the contextual factors that modulate tremor (stress, voluntary movements), and on focused interventions in the tremor circuitry
The impact of the COVID-19 pandemic on Parkinson's disease: Hidden sorrows and emerging opportunities
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220564.pdf (Publisher’s version ) (Open Access
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