161,267 research outputs found
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Enzymatic studies of alcohol dehydrogenase by a combination of in vitro and in silico methods
No full textThe family of alcohol dehydrogenases (ADHs) catalyzes conversions of alcohols, ketons and aldehydes. The early discovery and isolation of ADH (1937) was followed by numerous investigations. It was also the first dimeric enzyme for which the threedimensional structure was determined (1974). Recent findings have revealed new physiological functions for the ADH enzymes. One type is a key enzyme in hepatic retinol metabolism, another is a main formaldehyde scavenger and a regulator of Snitrosothiols levels. ADH genes have been shown to be connected to diseases and syndromes, such as alcoholism and asthma. Hence, investigations of structure-function relationships of the ADH enzymes are of both physiological and medical interest. The aim of this thesis was to study structure-function relationships and to investigate and identify ligands for ADH, with in vitro and in silico methods.The catalytic activities of human, mouse and rat ADH2 for retinoids, were determined. The Km values for human ADH2 are the lowest among all known human dehydrogenases, which supports a key role for human ADH2 in the hepatic retinoid metabolism. ADH3 is an enzyme with a proposed role as an NO scavenger. Two new lines of ligands, bile acids and fatty acids, were investigated for their potential effects on NO homeostasis. The bronco dilatatory effect of NO suggests that ADH3 inhibition could potentially work as treatment of obstructive lung disorders. The stability of the quaternary structure of sorbitol dehydrogenase (SDH) was determined by in vitro experiments and in silico energy calculations. A hydrogen-bonding network crucial for the tetrameric stability in SDH was identified. This network is located at a region enclosing the structural zinc site in mammalian ADHs.The structural zinc site was studied in detail by a combination of molecular dynamics and quantum mechanics simulations. The simulations revealed that the interaction between the cysteine residues and the zinc atom is of an electrostatic and covalent nature. With in silico and in vitro simulations, interactions between ligands and the active site were determined, revealing site specific interactions within both ADH2 and ADH3. Furthermore, studies of subunit interactions and the structural zinc site revealed properties of the quaternary stability.List of scientific papersI. Hellgren M, Strömberg P, Gallego O, Martras S, Farrés J, Persson B, Parés X, Höög JO (2007). Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism. Cell Mol Life Sci. 64(4): 498-505 https://pubmed.ncbi.nlm.nih.gov/17279314II. Hellgren M, Kaiser C, de Haij S, Norberg A, Höög JO (2007). A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power. Cell Mol Life Sci. 64(23): 3129-38 https://pubmed.ncbi.nlm.nih.gov/17952367III. Brandt EG, Hellgren M, Brinck T, Bergman T, Edholm O (2009). Molecular dynamics study of zinc binding to cysteines in a peptide mimic of the alcohol dehydrogenase structural zinc site. Phys Chem Chem Phys. 11(6): 975-83. Epub 2008 Dec 12 https://pubmed.ncbi.nlm.nih.gov/19177216IV. Staab CA, Hellgren M, Grafström RC, Höög JO (2009). Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3. Chem Biol Interact. 180(1): 113-8. Epub 2009 Jan 29 https://pubmed.ncbi.nlm.nih.gov/19428350V. Hellgren M, Carlsson J, Östberg L, Staab C.A, Persson B, Höög JO (2009). Virtual screening for ligands to human alcohol dehydrogenase 3. [Manuscript]</p
Visual function in very low birth weight adolescents : fifteen-year follow-up of children in southeast Sweden
No full textBackground: Very low birth weight (VLBW Aims: To describe visual functions in adolescents with VLBW in comparison with a matched control group and to investigate associations with white matter damage of immaturity (WMDI), optic disc measurements and cognitive functions in the VLBW group.Subjects (Papers I-III): A total of 86 VLBW children survived the neonatal period during a 15 months period in the southeast region of Sweden. Fifty-nine of those, and 55 term control infants, participated in the 15-year follow-up study. (Paper IV): A subgroup including 18 VLBW subjects and 29 control subjects participated.Methods: Structural assessments included brain MRI, digital analysis of fundus photographs and cycloplegic refraction. Functional evaluations comprised best corrected visual acuity, stereo acuity, visual fields, ocular alignment, fixation behavior, cognitive visual problems and intellectual level.Results: Twenty-eight percent of the VLBW subjects had WMDI. The mean neural retinal rim area was smaller - in normal sized optic discs - in the VLBW than in the control group (p=0.018). The VLBW adolescents had more tortuous retinal arterioles than the controls (pConclusion: This study confirms previous observations that adolescents with VLBW are at a disadvantage regarding visual and cognitive outcome compared with adolescents with normal birth weight. Adolescents with WMDI had more pronounced visual and cognitive dysfunction.List of scientific papersI. Hellgren K, Hellström A, Jacobson L, Flodmark O, Wadsby M, Martin L (2007). "Visual and cerebral sequelae of very low birth weight in adolescents." Arch Dis Child Fetal Neonatal Ed 92(4): F259-64. https://pubmed.ncbi.nlm.nih.gov/17314116 II. Hellgren K, Hellström A, Martin L (2008). "Visual fields and optic disc morphology in very low birthweight adolescents examined with magnetic resonance imaging of the brain." Acta Ophthalmol Sep 20: Epub ahead of print. https://pubmed.ncbi.nlm.nih.gov/18811637 III. Hellgren K, Aring E, Jacobson L, Ygge J, Martin L (2008). "Visuo-spatial skills, ocular alignment and MRI findings in very low birth weight adolescents." Journal of American Association for Pediatric Ophthalmology and Strabismus. [Accepted] https://doi.org/10.1016/j.jaapos.2008.11.008 IV. Hellgren K, Han Y, Ygge J (2009). "Fixation behaviour in very low birth weight and control adolescents." [Manuscript]</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Larry O. Spencer, Conference Author Presentation
No full textGen. Larry O. Spencer, USAF (Ret.), author of Dark Horse: A Journey from the Horseshoe to the Pentago
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author Under Sail The Imagination of Jack London, 1902-1907
No full textIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Cover -- Title Page -- Copyright Page -- Contents -- Acknowledgments -- Introduction -- 1. Howl, O Heav'nly Muse! -- 2. Jesus in the Theater of Socialism -- 3. Jack London's Place in American Literature -- 4. Theater of War, Theater at Home -- 5. Revolution, Evolution, and the Scene of Writing -- 6. The Jack London Show Goes on the Road -- 7. Red Atavisms and Revolution -- 8. Earthquake Apocalypse and Building the City, Boat, and House Beautiful -- 9. The Future of Socialism and the Death of the Individual -- 10. The Road Never Ends -- Notes -- Bibliography -- IndexIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
اسلم کولسری کی غزل:بیان و بدیع کے تناظر میں: ASLAM KOLSARY’S GHAZAL IN THE LIGHT OF BIAN-O-BADIE
No full textAslam kolsari is new significant and potentially well-known personality for contributing to modern Urdu ghazal. Being a mindful and multidimensional literary figure he has specific fame in poetry. A distinguish diction in poetry is individuality specifically connected with his name. His ghazal contains all attributes of Research and criticism. Communication of an ordinary concept in his poetry is reflection of Aslam kolasri. In this article the author has explored how poetic characteristics distinguished Aslam kolsari
Self-similar regimes in Unstably Stratified Homogeneous Turbulence
No full textUnstably stratified homogeneous turbulence develops at late time a self-similar dynamics characterized by an exponential growth of turbulent quantities. It is believed from recent theoretical studies that different growth rates are possible, depending on the initial distribution of energy at large scales. In order to confirm these predictions, we run both highly resolved direct numerical simulations and a spectral model based on an eddy-damped quasi-normal closure. In addition to confirming the influence of initial conditions, our study sheds light on the anisotropic structures of the self-similar regimes
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