2,749 research outputs found
Making use of historical case material – the problems of looking back and the implications for service development in relation to research and evaluation activities
No full textThis methodological paper details the process of embarking on a follow-up study of young people with sexual behaviour problems who were known to services in the 1990s and who are now young adults in their twenties or early thirties. In the context of the importance of such follow-up work, the overall aim and objectives of the funded research project are specified and the challenges presented in setting up research partnerships with service sites, including the negotiation of access and ethical approval, are the subject of overview and reflection. The practicalities of beginning the fieldwork which comprised an initial analysis of historical case material held in the research sites are then detailed and the solutions to the problems encountered are explained. The article concludes by identifying the kinds of questions services and researchers need to consider when wanting to engender or enhance a research culture which is facilitative of this kind of outcome research. These relate to the resources necessary to support a research culture, the requirements of data protection and ethical approval processes, obtaining service user consent to participate in future research, secure but accessible storage of records, staff development and researchers’ obligations to minimise disruption to already hard pressed services
Women's life writing 1760-1830 : spiritual selves, sexual characters, and revolutionary subjects
No full textPhDThis thesis uses print and manuscript sources to analyse and interpret women's life
writing at the end of the eighteenth and beginning of the nineteenth centuries. I
explore printed works by Catharine Phillips, Mary Dudley, Priscilla Hannah Gurney,
Ann Freeman, Elizabeth Steele, Mary Robinson, Helen Maria Williams, Mary
Wollstonecraft, Grace Dalrymple Elliott, and Charlotte West and discuss the
manuscripts of Mary Fletcher, Mary Tooth, Sarah Ryan, and Elizabeth Fox. Of these
sources, five have never been analysed in the critical literature and six have received
little attention. Considered as a group, this large corpus of texts offers new insights
into the personal and political implications of different models of female selfhood and
social being.
In chapter one, I compare the religious identities presented in the spiritual
autobiographies of Quakers and Methodists. For these women, religious identification
provides a powerful sense of social belonging and enables public participation.
However, it may also lead to a loss of self in the demand for religious conformity and
self-abnegation. In chapter two, I consider the life writing of late eighteenth-century
courtesans. These women adapt available models of femininity and female authorship
in order to establish themselves as socially connected subjects. However, their
narratives also reveal that dependence on the sexual and literary marketplace puts
female selfhood under pressure. In chapter three, I explore the eyewitness accounts of
British women in the French Revolution. I argue that, for these writers, connecting
personal identity to political history is an enabling source of self-definition but it also
exposes them to the risks of self-fragmentation.
In my focus on the social function of women's life writing, I present an alternative to
the traditional alignment of the eighteenth-century autobiographical subject with the
autonomous self of individualism. These narratives allow us to reconsider the
productive and problematic dialectic between personal expression and representative
selfhood, self-authorship and collective narratives, and individualism and social
being. They suggest that women's life writing has the potential to be both the self-expression
of a unique heroine and the self-inscription of a politicised subject
Earthworms (Clitellata, Megadrili) of the world: an updated checklist of valid species and families, with notes on their distribution
No full textMisirlioğlu, Mete, Reynolds, John Warren, Stojanović, Mirjana, Trakić, Tanja, Sekulić, Jovana, James, Samuel W., Csuzdi, Csaba, Decaëns, Thibaud, Lapied, Emmanuel, Phillips, Helen R. P., Cameron, Erin K., Brown, George G. (2023): Earthworms (Clitellata, Megadrili) of the world: an updated checklist of valid species and families, with notes on their distribution. Zootaxa 5255 (1): 417-438, DOI: 10.11646/zootaxa.5255.1.33, URL: http://dx.doi.org/10.11646/zootaxa.5255.1.3
The use of computational fluid dynamics to assess the hull resistance of concept autonomous underwater vehicles
No full textAutonomous Underwater Vehicles (AUV’s) provide an important tool for collecting detailed scientific information from the oceans depths. The hull resistance of an AUV is an important factor in determining the powering requirements and range of the vehicle. This paper discusses the use of Computational Fluid Dynamics (CFD) to determine the hull resistance of three existing AUV’s, of differing shape and size. The predictions are compared with available experimental data and good agreement found. This work has demonstrated that with use of suitable shape parameterisation it is possible to carry out concept design evaluation using a RANS flow solver
Simple drag prediction strategies for an Autonomous Underwater Vehicle’s hull shape
No full textThe range of an AUV is dictated by its finite energy source and minimising the energy consumption is required to maximise its endurance. One option to extend the endurance is by obtaining the optimum hydrodynamic hull shape with balancing the trade-off between computational cost and fluid dynamic fidelity. An AUV hull form has been optimised to obtain low resistance hull. Hydrodynamic optimisation of hull form has been carried out by employing five parametric geometry models with a streamlined constraint. Three Genetic Algorithm optimisation procedures are applied by three simple drag predictions which are based on the potential flow method. The results highlight the effectiveness of considering the proposed hull shape optimisation procedure for the early stage of AUV hull desig
Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers
No full textBackgroundThe MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour formation in individuals with inherited p53 mutations. We have investigated the effect of the MDM2 SNP309 on clinical outcome in a cohort of patients with germline mutations of BRCA1.MethodsGenomic DNA was obtained for 102 healthy controls and 116 patients with established pathogenic mutations of BRCA1 and Pyrosequencing technology™ was used to determine the genotype at the MDM2 SNP309 locus.ResultsThe polymorphism was present in 52.9% of the controls (G/T in 37.3% and G/G in 15.6%) and 58.6% of the BRCA1 mutation carriers (47.4% G/T and 11.2% G/G). Incidence of malignancy in female BRCA1 carriers was not significantly higher in SNP309 carriers than in wildtype (T/T) individuals (72.7% vs. 75.6%, p = 1.00). Mean age of diagnosis of first breast cancer was 41.2 years in the SNP309 G/G genotype carriers, 38.6 years in those with the SNP309 G/T genotype and 39.0 years in wildtype subjects (p = 0.80).ConclusionWe found no evidence that the MDM2 SNP309 accelerates tumour development in carriers of known pathogenic germline mutations of BRCA1
Komarekionidae Gates 1974
No full textKomarekionidae Gates, 1974 <p> There is only one species in this monogeneric Nearctic family: <i>Komarekiona eatoni</i> Gates. It is found only in the mid-Atlantic states west to southern Illinois, USA (Gates 1974; Reynolds 2020). Interestingly, the specimens east of the Smoky Mountains are amphimictic while those west of the Smokies are parthenogenetic (Reynolds 2020).</p>Published as part of <i>Misirlioğlu, Mete, Reynolds, John Warren, Stojanović, Mirjana, Trakić, Tanja, Sekulić, Jovana, James, Samuel W., Csuzdi, Csaba, Decaëns, Thibaud, Lapied, Emmanuel, Phillips, Helen R. P., Cameron, Erin K. & Brown, George G., 2023, Earthworms (Clitellata, Megadrili) of the world: an updated checklist of valid species and families, with notes on their distribution, pp. 417-438 in Zootaxa 5255 (1)</i> on page 424, DOI: 10.11646/zootaxa.5255.1.33, <a href="http://zenodo.org/record/7745110">http://zenodo.org/record/7745110</a>
Kazimierzidae Nxele & Plisko 2016
No full textKazimierzidae Nxele & Plisko, 2016 This recently erected family of earthworms, which includes 25 nominal species all in the single genus Kazimierzus, is restricted to the Western Cape and Northern Cape provinces, including the Namaqualand areas, along the Atlantic region of South Africa. This is a hotspot of biodiversity (Myers et al. 2000), with considerable topographical and botanic diversity, which will probably still lead to the discovery of new earthworm species, as observed by Nxele et al. (2017).Published as part of Misirlioğlu, Mete, Reynolds, John Warren, Stojanović, Mirjana, Trakić, Tanja, Sekulić, Jovana, James, Samuel W., Csuzdi, Csaba, Decaëns, Thibaud, Lapied, Emmanuel, Phillips, Helen R. P., Cameron, Erin K. & Brown, George G., 2023, Earthworms (Clitellata, Megadrili) of the world: an updated checklist of valid species and families, with notes on their distribution, pp. 417-438 in Zootaxa 5255 (1) on page 424, DOI: 10.11646/zootaxa.5255.1.33, http://zenodo.org/record/774511
Sparganophilidae Michaelsen 1918
No full textSparganophilidae Michaelsen, 1918 This family native to North America has only one genus (Sparganophilus), with 12 species and 2 subspecies (Reynolds 1980, 2008). At least one species, Sparganophilus tamesis Benham (Sparganophilus eiseni Smith, is a junior synonym of S. tamesis; see Rota et al. 2016), is cosmopolitan, and found mainly in limicole habitats, throughout the USA (within and outside of its native range), Mexico (Ikeda et al. 2020), Canada (Reynolds 2022) and in several European countries including Germany, France, England, Switzerland, Italy and Spain (Rota et al. 2018a; Bouché & Qiu 1998).Published as part of Misirlioğlu, Mete, Reynolds, John Warren, Stojanović, Mirjana, Trakić, Tanja, Sekulić, Jovana, James, Samuel W., Csuzdi, Csaba, Decaëns, Thibaud, Lapied, Emmanuel, Phillips, Helen R. P., Cameron, Erin K. & Brown, George G., 2023, Earthworms (Clitellata, Megadrili) of the world: an updated checklist of valid species and families, with notes on their distribution, pp. 417-438 in Zootaxa 5255 (1) on page 428, DOI: 10.11646/zootaxa.5255.1.33, http://zenodo.org/record/774511
Tritogeniidae Plisko 2013
No full textTritogeniidae Plisko, 2013 The family Tritogeniidae was erected by Plisko(2013) as part of important housekeeping duties within the Microchaetidae, and includes two genera, Michalakus with a single species and the others all belonging to Tritogenia. All 39 species are endemic to Southern Africa, with only one species newly described from Botswana (Nxele et al. 2018).Published as part of Misirlioğlu, Mete, Reynolds, John Warren, Stojanović, Mirjana, Trakić, Tanja, Sekulić, Jovana, James, Samuel W., Csuzdi, Csaba, Decaëns, Thibaud, Lapied, Emmanuel, Phillips, Helen R. P., Cameron, Erin K. & Brown, George G., 2023, Earthworms (Clitellata, Megadrili) of the world: an updated checklist of valid species and families, with notes on their distribution, pp. 417-438 in Zootaxa 5255 (1) on page 429, DOI: 10.11646/zootaxa.5255.1.33, http://zenodo.org/record/774511
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