922 research outputs found
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Cervantes, Rowe, Venturi & Scott Brown; Manieras...
No full textEl artículo aborda la figura intelectual del angloestadounidense Colin Rowe, de una forma fragmentada, incidiendo en algunos aspectos que han marcado hitos en la historiografía y la interpretación arquitectónica del siglo XX. Se establece una reflexión sobre la presencia de Rowe en la actualidad, entre las generaciones de estudiantes que cursan arquitectura para seguidamente establecer algunas cuestiones consideradas de relevancia. La innovación en los mecanismos interpretativos de este autor, muy avanzados, que permiten una comprensión muy significativa en tiempos posteriores, tales como los conceptos de transparencia literal, transparencia fenomenal, son analizados como influencias en el curso del tiempo, apertura de nuevas posibilidades. El espacio geográfico y cultural de Italia, es otra de las fuentes en la obra de Rowe sobre la que se reflexiona en una perspectiva que introduce la imagología como un estadio previo de los mecanismos con los que diferentes culturas son visualizadas, interpretadas y recibidas. Una centralidad que no debía evitarse, es el concepto del aprovechamiento del manierismo como una metáfora que se traslada a lo contemporáneo, para de un modo perspicaz alumbrar comparaciones e interpretaciones arquitectónicas que resultan muy novedosas en su momento y alumbran su propio futuro. Una especulación comparada entre Rowe y Venturi, con la interpretación de algunas obras de éste último, nos sitúa en la continuidad y recuperación actual que el manierismo como heterodoxia puede aportar en el abordaje presente de la arquitectura. Finalmente, contextualizar a Rowe en el ámbito español, era necesario por enriquecer las teselas del mosaico de sus geografías transitadas.The article addresses the intellectual !gure of the Anglo-American Colin Rowe, in a fragmented
way, focusing on some aspects that have marked milestones in the historiography and architectural
interpretation of the 20th century. A re#ection is established on Rowe ‘s presence today, among the
generations of students who study architecture, to then establish some issues considered relevant.
e innovation in the interpretive mechanisms of this author, very advanced, which allow very
signi!cant advances in later times, such as the concepts of literal transparency, phenomenal
transparency, are analyzed as in#uences on the course of time and opening of new possibilities. e
geographical and cultural space of Italy is another source in Rowe ‘s work that is re#ected on in a
perspective that introduces imagology as a previous stage of the mechanisms with which di%erent
cultures are visualized, interpreted and received. A centrality that should not be avoided is the
concept of using mannerism as a metaphor that is transferred to the contemporary, to illuminate
in a perceptive way architectural comparisons and interpretations that are very novel at the time
and illuminate their own future. A comparative speculation between Rowe and Venturi, with the
interpretation of some of the latter’s works, places us in the continuity and current recovery that
mannerism as heterodoxy can contribute to the present approach to architecture. Finally,
contextualizing Rowe in the Spanish context was necessary to enrich the tiles of the mosaic of his
traveled geographiesO artigo aborda a !gura intelectual do anglo-americano Colin Rowe, de forma fragmentada,
enfocando alguns aspectos que marcaram marcos na historiogra!a e interpretação arquitetônica do
século XX. Estabelecese uma re#exão sobre a presença de Rowe hoje, entre as gerações de estudantes
que estudam arquitetura, para então estabelecer algumas questões consideradas relevantes. A
inovação nos mecanismos interpretativos deste autor, muito avançados, que permitem avanços
muito signi!cativos em tempos posteriores, como os conceitos de transparência literal, transparência
fenomenal, são analisadas como in#uências no curso do tempo e abertura de novas possibilidades.
O espaço geográ!co e cultural da Itália é outra fonte da obra de Rowe que se re#ete numa perspectiva
que introduz a imagologia como etapa prévia dos mecanismos com os quais as diferentes culturas
são visualizadas, interpretadas e recebidas. Uma centralidade que não deve ser evitada é o conceito
de utilizar o maneirismo como metáfora que se transfere para o contemporâneo, para iluminar de
forma perspicaz comparações e interpretações arquitetónicas muito inovadoras na época e que
iluminam o seu próprio futuro. Uma especulação comparativa entre Rowe e Venturi, com a
interpretação de algumas obras deste último, colocanos na continuidade e na recuperação actual de
que o maneirismo enquanto heterodoxia pode contribuir para a abordagem actual da arquitectura.
Por !m, contextualizar Rowe no contexto espanhol foi necessário para enriquecer os azulejos do
mosaico das suas geogra!as viajada
Plasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies
No full textRosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions. Previous work showed that rosetting does not enhance parasite invasion under standard in vitro conditions. We hypothesised that rosetting might promote invasion in the presence of host invasion-inhibitory antibodies, by allowing merozoites direct entry into the erythrocytes in the rosette and so minimising exposure to plasma antibodies. We therefore investigated whether rosetting influences invasion in the presence of invasion-inhibitory antibodies to MSP-1. We found no difference in invasion rates between isogenic rosetting and non-rosetting lines from two parasite strains, R29 and TM284, in the presence of MSP-1 antibodies (P = 0.62 and P = 0.63, Student's t test, TM284 and R29, respectively). These results do not support the hypothesis that rosettes protect merozoites from inhibitory antibodies during invasion. The biological function of rosetting remains unknown
RDA I 1977 (M-Y)
No full textBlack and white photo; unmounted.Back - David Morris, Gino Pacitti, Sharon Pecker, Lincoln Rowe, Judith Rowntree; centre - Craig Sampson, Donald Schinkel, Alan Schwarz, John Spry, Bruce Stark, Stephen Tunstill; front - Rodger Tynan, Helen Williams, Stuart Wilson, Shane Wood, Fred Woods, Mark Young
Behaviour of buried pipelines subjected to external loading.
No full textThe research presented in this Thesis was carried out at the University of Sheffield under
the supervision of Dr I. C. Pyrah and Dr W. F. Anderson, and Mr G. Leach at British Gas
Engineering Research Station (ERS). The research was financially supported by a British
Gas Research Scholarship and by the Overseas Research Students Awards Scheme.
The Author would like to express his sincere gratitude to his supervisors for their invaluable
help, guidance and encouragement during the development of the research.
The Author is also grateful to Dr S. R. Mi for his interest and assistance throughout the
research. Special thanks also go to Dr S. J. Wheeler for his supervision during the first year
of the research and sound advice in the initial stage of the work.
The Author would like to express his gratitude to all members of the geotechnics group at
the University of Sheffield for the useful discussions and comments. Special thanks and
appreciation are extended to the staff at the ERS, particularly Mr E. Middleton for
providing the data of the field tests and constructive comments.
The laboratory tests were performed at ERS Soils Laboratory for which the Author is
thankful to the laboratory staff. The Author must also thank British Gas for providing the
computer hardware and software for performing the numerical analyses, and the printing
facilities to produce the Thesis. Thanks also go to Mr D. Reay and Mr B. Bellwood at the
Gas Research Centre of British Gas for ensuring continuous financial support throughout
the award period.
Finally, the Author wishes to thank his family and friends for their endless support and
encouragement throughout the period of study in the UK. Without them, this Thesis may
never have been completed
Hybrid Rowe cell for measurement of complex conductivity
No full textPeat is sediment consisting of incompletely decomposed organic matter deposited in swamp and marsh. It has served for a long time as benefits for human beings. Meanwhile, it has posed huge challenges to geotechnical engineers because of its unique characteristics such as anisotropy, low stiffness, high compressibility and strong creep susceptibility. In order to realise more effective and efficient site investigations, it is highly expected to apply geophysical techniques as well as core-boring, CPTs, sampling and laboratory tests because the techniques promise to be great contributions not only for two- or three-dimensional mapping but also for accurate interpretation of its physical, chemical and engineering properties in non-destructive way. Then, a new apparatus has been developed, called hybrid Rowe cell. It combines the functions of a traditional hydraulic cell and an electrical capacitor. This can simultaneously measure electrical properties and physical, mechanical and hydrological properties of soil samples, allowing to investigate their correlation accurately. This work focuses on the study of the applicability and calibration of the new hybrid cell, and the relationship between electrical conductivities of bulk peat and pore water which saturates the sample. The applicability of the hybrid cell was examined by using water as calibration. The results were then compared with values reported earlier and the experimental set-up was also compared with similar one found in literature. As a result, it was proven that the new cell successfully prevented electrode polarization and was applicable for this type of measurements. The electrical measurements on peat showed a relationship between the electrical conductivities of bulk peat and pore water which could be well predicted by a model previously developed for peat as well as the modified Archie’s law. In addition, the modified Archie’s law could be considered to be a persuasive model for the electrical behaviours observed in this study. For the future research, it is highly expected that the frequency of input currents is extended to lower range (< 20 Hz), input electric currents are properly controlled to avoid non-linear effects, and also hydraulic consolidation tests are performed in parallel with electrical measurements.Geo-EngineeringGeotechnologyCivil Engineering and Geoscience
Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene
No full textComplement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of the CR1 gene. The L allele confers protection against severe malaria in Papua New Guinea, probably because erythrocytes with low CR1 expression, are less able to form pathogenic rosettes with Plasmodium falciparum-infected erythrocytes. Despite the biological importance of erythrocyte CR1, the genetic mutation controlling CR1 expression level remains unknown. We investigated the possibility that mutations in the upstream or 3' untranslated regions of the CR1 gene could control erythrocyte CR1 level. We identified several novel polymorphisms; however, the mutations did not segregate with erythrocyte CR1 expression level or the H and L alleles. Therefore, high and low erythrocyte CR1 levels cannot be explained by polymorphisms in transcriptional control elements in the upstream or 3' untranslated regions of the CR1 gene
Contextualizando a Colin Rowe con Jane Jacobs: complejidad, contexto y dependencia en la arquitectura
No full textMBArch - Màster Universitari en Estudis Avançats en Arquitectura-Barcelona: Teoria, Història i CulturaEn 1947, Colin Rowe, por medio del ensayo Las matemáticas de la vivienda ideal, probaría de manera irrefutable, por medio de una atrevida comparación entre la Villa Stein en Garches de Le Corbusier y La Malcontenta en el Veneto de Andrea Palladio, que la arquitectura del movimiento moderno “no era revolucionaria y separada de la historia, como pretendía ser, sino evolucionaria y conectada con la historia”. Este ensayo se inspira en esa atrevida comparación para, por medio de una yuxtaposición de las principales obras sobre la ciudad del mismo Colin Rowe y de Jane Jacobs, activista y autora de Muerte y Vida de las Grandes Ciudades, acercar a los dos personajes, mostrar similitudes en su pensamiento y sugerir que la arquitectura (y el diseño urbano) no es ni debe ser una disciplina autónoma, y que es mas bien dependiente de las estructuras sociales, políticas y económicas dentro de las cuales opera. El ensayo aborda temas de complejidad, contexto y dependencia en la arquitectura.In 1947, Colin Rowe, in the essay The Mathematics of the Ideal Villa, would prove irrefutably, through a comparison between Villa Stein in Garches by Le Corbusier and La Malcontenta in the Veneto by Andrea Palladio, that the modern architecture movement “was not revolutionary, as it was supposed to be, but rather evolutionary and connected to history”. This essay is inspired on that comparison in order to, by means of a juxtaposition of the main texts on the city written by Colin Rowe himself and Jane Jacobs, activist and author of Death and Life of Great American Cities, bring these two characters closer together, show similarities in their thought and suggest that architecture (and urban design) is not and should not be considered an autonomous discipline, but is rather dependent on the social, political and economic structures within which it operates. The essay addresses issues of complexity, context and dependence in architecture.Objectius de Desenvolupament Sostenible::5 - Igualtat de Gèner
Contextualizando a Colin Rowe con Jane Jacobs: complejidad, contexto y dependencia en la arquitectura
No full textMBArch - Màster Universitari en Estudis Avançats en Arquitectura-Barcelona: Teoria, Història i CulturaEn 1947, Colin Rowe, por medio del ensayo Las matemáticas de la vivienda ideal, probaría de manera irrefutable, por medio de una atrevida comparación entre la Villa Stein en Garches de Le Corbusier y La Malcontenta en el Veneto de Andrea Palladio, que la arquitectura del movimiento moderno “no era revolucionaria y separada de la historia, como pretendía ser, sino evolucionaria y conectada con la historia”. Este ensayo se inspira en esa atrevida comparación para, por medio de una yuxtaposición de las principales obras sobre la ciudad del mismo Colin Rowe y de Jane Jacobs, activista y autora de Muerte y Vida de las Grandes Ciudades, acercar a los dos personajes, mostrar similitudes en su pensamiento y sugerir que la arquitectura (y el diseño urbano) no es ni debe ser una disciplina autónoma, y que es mas bien dependiente de las estructuras sociales, políticas y económicas dentro de las cuales opera. El ensayo aborda temas de complejidad, contexto y dependencia en la arquitectura.In 1947, Colin Rowe, in the essay The Mathematics of the Ideal Villa, would prove irrefutably, through a comparison between Villa Stein in Garches by Le Corbusier and La Malcontenta in the Veneto by Andrea Palladio, that the modern architecture movement “was not revolutionary, as it was supposed to be, but rather evolutionary and connected to history”. This essay is inspired on that comparison in order to, by means of a juxtaposition of the main texts on the city written by Colin Rowe himself and Jane Jacobs, activist and author of Death and Life of Great American Cities, bring these two characters closer together, show similarities in their thought and suggest that architecture (and urban design) is not and should not be considered an autonomous discipline, but is rather dependent on the social, political and economic structures within which it operates. The essay addresses issues of complexity, context and dependence in architecture.Objectius de Desenvolupament Sostenible::5 - Igualtat de Gèner
Music and Dance. volume 53 issue 1, 1962
No full textBolshoi Ballet (Bol'shoi teatr SSSR. Balet); Claudio Arrau (Arrau, Claudio, 1903-1991); Covent Garden (Covent Garden Theatre); David Simon (Simon, David); Edith Georges (Georges, Edith); Edward Miller (Miller, Edward); Hartwell Eisteddfod; Helen Sharpe (Sharpe, Helen); Irina Tichomirnova (Tichomirnova, Irina); James Penberthy (Penberthy, James, 1917 - 1999); Kelvin Coe (Coe, Kelvin, 1946-1992); Lesley Hansen (Hansen, Lesley); Leslie Sinclair (Sinclair, Leslie); Ludmila Bogomolova (Bogomolova, Ludmila); Mabel Chamberlain (Chamberlain, Mabel); Maiya Plisetskaya (Plisetskaya, Maiya Mikhailovna, 1926-); Martin M Manelis (Manelis, Martin M); Mary Duchesne (Duchesne, Mary, 1932-1996); Maxine Rowe (Rowe, Maxine); Peter Williams (Williams, Peter); Rex Reid (Reid, Rex); Robert Hughes (Hughes, Robert, 1912-2007); Robyn Croft (Croft, Robyn); S Vlasov (Vlasov, Stanislav Konstantinovic, 1933-); Sydney Eisteddfod (City of Sydney Eisteddfod); Vala Collins (Collins, Vala); Will Sterling (Sterling, Will); Willem van Otterloo (Otterloo, Willem van, 1907-1978
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