1,721,082 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Análisis de los cambios en la expresión génica inducidos por el tratamiento con pseudoterosina en la línea celular de cáncer de mama MDA-MB231
Full text linkDe acuerdo a cifras publicadas por la Organización Mundial de la Salud, el cáncer de mama es una de las patologías con mayor porcentaje de mortalidad e incidencia en las mujeres, y en este sentido es necesario el desarrollo de nuevas alternativas para su tratamiento (Saucedo, 2013). Hoy en día están en uso clínico al menos 121 fármacos antineoplásicos que no cubren todas las necesidades de tratamiento, y es pertinente continuar investigando nuevas moléculas activas que presenten mayor efectividad y selectividad, y menor toxicidad y susceptibilidad a la generación de resistencia por parte de las células tumorales. (Gibbs, 2000; Sausville y Johnson, 2000; Newman y Cragg, 2007; Cordero, 2008; Escobar, 2011). Para alcanzar este objetivo se deben buscar compuestos activos que presenten nuevos mecanismos de acción, ya que la mayoría de los antineoplásicos de uso clínico están diseñados para afectar la maquinaria de replicación celular, esta teoría se basa en que las células tumorales por su rápida proliferación son más sensibles a los agentes citotóxicos que las células normales. (Marchini et al., 2005). El descubrimiento de la selectividad y actividad terapéutica potencial de las moléculas pseudopterosinas aisladas del octocoral Antiollogorgia elisabethae, (Williams y Chen, 2012) y el alto grado de variación química de las especies colectadas a diferentes localizaciones de la región Caribe, han motivado a muchos autores para continuar el estudio de estos productos (Correa et al., 2011); especialmente en este trabajo se estudió el compuesto Pseudopterosina Q, con promisoria actividad anticancerígena, contribuyendo al estudio de su mecanismo de acción in vitro. Utilizando un microarreglo de expresión en genes humanos, que emplea la tecnología Agilent de dos colores (Agilent SurePrint G3 Humano Gene Expression 8x60K Microarray GE V2), se generó información sobre las diferentes dianas en las que actúa este compuesto, permitiendo un acercamiento al análisis de las posibles rutas moleculares principalmente impactadas sobre la línea celular MDA-MB231 al ser tratadas con el compuesto. Se hibridó bajo dos condiciones: una con exposición de las células MDA-MB231 al tratamiento y otra sin exposición, empleando un chip con 8 arreglos que constan de 4 réplicas biológicas, cada una con 2 réplicas técnicas. Se utilizó la plataforma Bioconductor y el lenguaje de programación estadística R. El resultado fue de 3.400 genes impactados por la actividad citotóxica del compuesto; concluimos que todos los mecanismos de protección celular en respuesta al estrés generado por PsQ, se relacionan con supervivencia, diferenciación, crecimiento, movilidad, migración celular y represión del proceso apoptótico. No se soportan evidencias de repuesta temprana pero si evidencias de muerte celular por procesos de necrosis.Abstract. According to published by the World Health Organization, breast cancer is one of the diseases of highest mortality and incidence in women, so it is necessary the development of new treatments research (Saucedo, 2013). Today are in clinical use at least 121 cancer drugs, that not cover all the needs of treatment, which is necessary to continue research into the development of new active molecules with greater effectiveness, lower toxicity, greater selectivity and reduced susceptibility to the generation of resistance by tumor cells. (Gibbs, 2000; Sausville y Johnson, 2000; Newman y Cragg, 2007; Cordero, 2008; Escobar, 2011). To get this goal it should search active compounds with novel mechanisms of action, since most antineoplastic clinical use are designed to affect the cellular replication machinery, this theory is based on the tumor cells by their rapid proliferation are more sensitive to cytotoxic agents than normal cells (Marchini et al., 2005). The discovery of the selectivity and potential therapeutic activity of molecules pseudopterosins isolated from the octocoral Antiollogorgia elisabethae, (Williams y Chen, 2012) and the high degree of chemical variation of species collected at different locations over Caribbean region, have led many authors to continue the study of these products (Correa et al., 2011). In this work, Pseudopterosin Q compound, with promising anticancer activity, contributing to the study of its mechanism of action in vitro. Using a human gene expression microarray employing the Agilent technology two-color (Agilent SurePrint G3 Humano Gene Expression 8x60K Microarray GE V2), generate information on different targets in which this compound acts, allowing closer analysis of possible molecular pathways impacted mainly on the cell line MDA- MB231. The samples was hybridized under two conditions: first, with exposure of MDA-MB231 cells without treatment and another exposure using a chip with eight arrays consisting of four biological replicates, each with 2 technical replicates. The Bioconductor plataform and statistical programming language R. The result was used 3,400 genes impacted by the cytotoxic activity of the compound; conclude that all cellular protection mechanisms in response to stress generated PSQ are related to survival, differentiation, growth, motility, cell migration and suppression of apoptosis. No evidence of early response but with evidence of cell death by necrosis processes supported.Maestrí
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
- …
