18,692 research outputs found
Dataset to support the article "High-resolution 𝜙-OFDR using phase unwrap and nonlinearity suppression"
No full textThis dataset is used for realizing high resolution of phase-sensitive Optical Frequency Domain Reflectometer. It is associated with the research paper:
Guo Z, Yan J, Han G, Yu Y, Greenwood D and Marco J (2023) "High-Resolution φ-OFDR Using Phase Unwrap and Nonlinearity Suppression". Journal of Lightwave Technology, 41 (9), 2885-2891. (https://doi.org/10.1109/JLT.2023.3236775).
The data is presented as an excel file:
High_resolution_OFDR_using_phase_unwrap_and_nonlinearity_suppression.xlsx
This work was funded by High Value Manufacturing Catapult and the Engineer and Physical Sciences Research Council - EPSRC EP/V000624/1. The author Gaoce Han would like to acknowledge the China Scholarship Council for sponsoring.</span
Han Suyin (Chinese author) speaking at Dallas Brookes Hall.
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/276390Han Suyin (Chinese author) speaking at Dallas Brookes Hall.200056
Item: [1999.0081.00439] "Han Suyin (Chinese author) speaking at Dallas Brookes Hall.
A Study on the mathematics textbooks in the era of the Great Han Empire
No full text이 글은 갑오경장(1894)과 경술 국치(1910) 사이에 간행된 산학(수학) 교재류의 목록을 확인하고, 각 텍스트의 출판과 관련된 사항, 소장처, 이본 등의 서지적 정보와 함께 이 시기 산학 교재류의 국어사 자료로서의 의의를 언어 사용 상의 측면에 초점을 두어 정리하는 것을 목적으로 한다. 이는 현대 한국어 태동기의 분과 학문의 도입 양상에 대한 연구의 일환인 한편, 학술 용어의 번역과 정착을 중심으로 이 시기의 한국어의 어휘 확장 양상을 확인하는 데에 필요한 기초 자료를 정리하는 작업의 한 부분이다. 본 연구에 앞선 산학(수학) 교재류에 대한 연구로는 산학 교재류의 서지 사항에 대해 기술한 강윤호(1973:187-199), 김봉희(1992:247-253), 한길준(2009), 오채환 외(2010) 등이 있고, 한국 수학사를 기술하면서 교재류를 함께 다룬 것으로 김용운·김용국(1982)와 이상구(2013)이 있다.This paper aims to make a whole list of the mathematics textbooks in the era of the Great Han Empire and summerize bibliographical data and linguistic characteristics in view of Korean history. In chapter 1, the author reviewed former studies which deals with the mathematics textbooks in the era of the Great Han Empire. In chapter 2, the author summerized bibliographical data of 45 volumes of 32 kinds textbooks. In chapter 3, the author described linguistic characteristics of the textbooks, especially focusing on writing systems, the use of Arabic numerals, horizontal writing, and presence of index or glossary
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Dataset to support the article "High Sensing Accuracy Realisation with Millimetre/sub-Millimetre Resolution in Optical Frequency Domain Reflectometer"
No full textThis dataset is used for realizing high sensing accuracy and sub-millimetre resolution of Optical Frequency Domain Reflectometer. It is associated with the research paper "High Sensing Accuracy Realisation with Millimetre sub-Millimetre Resolution in Optical Frequency Domain Reflectometer" in Journal: Journal of Lightwave Technology.
This work was funded by High Value Manufacturing Catapult, grant reference, 160080 CORE (WMG), titled ‘Smart Sensing for Future Batteries’ and the EPSRC (Engineering and Physical Sciences Research Council), grant reference EP/R004927/1, titled ‘Prosperity Partnership’. The author Gaoce Han would like to acknowledge the China Scholarship Council for sponsoring.</span
Allylic Acetals as Acrolein Oxonium Precursors in Tandem C−H Allylation and [3+2] Dipolar Cycloaddition
No full text© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimThe ruthenium(II)-catalyzed C−H functionalization of (hetero)aryl azomethine imines with allylic acetals is described. The initial formation of allylidene(methyl)oxoniums from allylic acetals could trigger C(sp2)−H allylation, and subsequent endo-type [3+2] dipolar cycloaddition of polar azomethine fragments to deliver valuable indenopyrazolopyrazolones. The utility of this method is showcased by the late-stage functionalization of bioactive molecules such as estrone and celecoxib. Combined experimental and computational investigations elucidate a plausible mechanism of this new tandem reaction. Notably, the reductive transformation of synthesized compounds into biologically relevant diazocine frameworks highlights the importance of the developed methodolog
KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson’s Disease
No full text© 2021, The Author(s).Monoamine oxidase-B (MAO-B) is a well-established therapeutic target for Parkinson’s disease (PD); however, previous clinical studies on currently available irreversible MAO-B inhibitors have yielded disappointing neuroprotective effects. Here, we tested the therapeutic potential of KDS2010, a recently synthesized potent, selective, and reversible MAO-B inhibitor in multiple animal models of PD. We designed and synthesized a series of α-aminoamide derivatives and found that derivative KDS2010 exhibited the highest potency, specificity, reversibility, and bioavailability (> 100%). In addition, KDS2010 demonstrated significant neuroprotective and anti-neuroinflammatory efficacy against nigrostriatal pathway destruction in the mouse MPTP model of parkinsonism. Treatment with KDS2010 also alleviated parkinsonian motor dysfunction in 6-hydroxydopamine-induced and A53T mutant α-synuclein overexpression rat models of PD. Moreover, KDS2010 showed virtually no toxicity or side effects in non-human primates. KDS2010 could be a next-generation therapeutic candidate for PD.11Nsciescopu
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient
No full textThe neuronal activity-dependent change in the manner in which light is absorbed or scattered in brain tissue is called the intrinsic optical signal (IOS), and provides label-free, minimally invasive, and high spatial (similar to 100 mu m) resolution imaging for visualizing neuronal activity patterns. IOS imaging in isolated brain slices measured at an infrared wavelength (>700 nm) has recently been attributed to the changes in light scattering and transmittance due to aquaporin-4 (AQP4)-dependent astrocytic swelling. The complexity of functional interactions between neurons and astrocytes, however, has prevented the elucidation of the series of molecular mechanisms leading to the generation of IOS. Here, we pharmacologically dissected the IOS in the acutely prepared brain slices of the stratum radiatum of the hippocampus, induced by 1 s/20 Hz electrical stimulation of Schaffer-collateral pathway with simultaneous measurement of the activity of the neuronal population by field potential recordings. We found that 55% of IOSs peak upon stimulation and originate from postsynaptic AMPA and NMDA receptors. The remaining originated from presynaptic action potentials and vesicle fusion. Mechanistically, the elevated extracellular glutamate and K+ during synaptic transmission were taken up by astrocytes via a glutamate transporter and quinine-sensitive K2P channel, followed by an influx of water via AQP-4. We also found that the decay of IOS is mediated by the DCPIB- and NPPB-sensitive anion channels in astrocytes. Altogether, our results demonstrate that the functional coupling between synaptic activity and astrocytic transient volume change during excitatory synaptic transmission is the major source of IOS. © Experimental Neurobiology 2019.11Nsciekc
Reactivity of Morita-Baylis-Hillman Adducts in C-H Functionalization of (Hetero)aryl Nitrones: Access to Bridged Cycles and Carbazoles
No full textThe rhodium(III)-catalyzed cross-coupling of (hetero)aryl nitrones with Morita-Baylis-Hillman (MBH) adducts is described. An allylated intermediate derived from aryl nitrones and MBH adducts allows the formation of bridged cyclic compounds via an exotype [3 + 2] cycloaddition. In sharp contrast, electron-rich indolinyl or aniline substrates were found to couple with MBH adducts to generate naphthalene or carbazole derivatives, respectively.
Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC(swell)) in the Brain
No full textIn the brain, a reduction in extracellular osmolality causes water-influx and swelling, which subsequently triggers Cl - and osmolytes-efflux via volume-regulated anion channel (VRAC). Although LRRC8 family has been recently proposed as the pore-forming VRAC which is activated by low cytoplasmic ionic strength but not by swelling, the molecular identity of the pore-forming swelling-dependent VRAC (VRAC(swell)) remains unclear. Here we identify and characterize. Tweety- homologs (TTYH1, TTYH2, TTYH3) as the major VRAC(swell) in astrocytes. Gene-silencing of all Ttyh1/2/3 eliminated hypo-osmotic-solution-induced Cl- conductance (I-Cl,I-swell) in cultured and hippocainpal astrocytes. When heterologously expressed in HEK293T or CHO-K1 cells, each TTYH iso-form showed a significant I-Cl,I-swell with similar aquaporin-4 dependency, pharmacological properties and glutamate permeability as I-Cl,I-swell observed in native astrocres. Mutagenesis-based structure-activity analysis revealed that positively charged arginine residue at 165 in TTYH1 and 164 in TTYH2 is critical for the formation of the channel-pore. Our results demonstrate that TTYH family confers the bona fide VRAC(swell) in the brain. © Experimental Neurobiology 2019.11Nsciekc
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