1,720,965 research outputs found
Contribution of Clinical Biochemistry to Structural Bioinformatics
No full textAbstract Bioinformatics plays an important role in the study of human diseases with genomic data for drug development and gene therapy. Its applicative arm is clinical biochemistry that focuses on the methodology and interpretation of chemical tests performed to support diagnosis and treatment. Clinical biochemistry is one of the most important parts of laboratory diagnostics tests together with laboratory hematology, immunology, clinical serology and microbiology, clinical toxicology. It possesses the largest number of diagnostic tests that help to understand pathogenesis and etiology of different pathological processes. Clinical biochemistry is based on bioinformatics applications that have been used for tumor marker measurements, stem cell tests, gene expression, and DNA damage repair. Bioinformatics field can be derived from biochemistry. It means that biochemistry has emerged from bioinformatics applications. It is not an overstatement to say that bioinformatics is what biochemistry is evolving to become a distinct guide for quality control. This paper focuses on the point of contemporary clinical biochemistry that tends to support bioinformatics researchers. Integration between biochemistry and bioinformatics would lead to an increase in healthcare performance is thus of increasing importance in future research
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Computer-Aided Diagnosis of Speech Disorder Signal in Parkinson’s Disease
No full textComputer-aided diagnosis (CAD) can be used as a decision support system by physicians in the diagnosis and treatmentof disordered speech especially those who specialize in neurophysiology diseases. Parkinson's disease (PD) is aprogressive disorder of the nervous system that affects movement. It develops gradually, sometimes starting with a barelynoticeable tremor in speech. It has been found that 80% of persons with PD reported speech and voice disorders.Parkinson's disease symptoms worsen as the condition progresses over time. Therefore, Speech may become soft orslurred and these deficits in speech intelligibility impact on health status and quality of life. Different researchers arecurrently working in the analysis of speech signal of people with PD, including the study of different dimensions in speechsuch as phonation, articulation, prosody, and intelligibility. Here, we present the characteristics and features of normalspeech and speech disorders in people with PD and the types of classification for implementation of the efficacy oftreatment interventions. The results show that our classification algorithm using ANN is outperformed KNN and SVM. ANNis a practical and useful as a predictive tool for PD screening with a high degree of accuracy, approximately 96.1% of acorrect detection rate (sensitivity 94.7%, and specificity 96.6%). Based on the high levels of accuracy obtained by ourproposed algorithm, it can be used for enhancing the detection purpose to discriminate PD patients from healthy people.Our algorithm may be used by the clinicians as a tool to confirm their diagnosis.</jats:p
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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