1,720,960 research outputs found
Rhododendron mingii (Ericaceae), a new species from Southeast of Yunnan, China
Liu, Zhenwen, Liu, Ende, He, Deming, Ma, Yongpeng, Gao, Lianming (2023): Rhododendron mingii (Ericaceae), a new species from Southeast of Yunnan, China. Phytotaxa 619 (1): 97-104, DOI: 10.11646/phytotaxa.619.1.5, URL: http://dx.doi.org/10.11646/phytotaxa.619.1.
Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis
Background: endometriosis is a frequently occurring disease in women, which seriously affects their quality of life. However, its etiology and pathogenesis are still unclear.Methods: to identify key genes/pathways involved in the pathogenesis of endometriosis, we recruited 3 raw microarray datasets (GSE11691, GSE7305, and GSE12768) from Gene Expression Omnibus database (GEO), which contain endometriosis tissues and normal endometrial tissues. We then performed in-depth bioinformatic analysis to determine differentially expressed genes (DEGs), followed by gene ontology (GO), Hallmark pathway enrichment and protein-protein interaction (PPI) network analysis. The findings were further validated by immunohistochemistry (IHC) staining in endometrial tissues from endometriosis or control patients.Results: we identified 186 DEGs, of which 118 were up-regulated and 68 were down-regulated. The most enriched DEGs in GO functional analysis were mainly associated with cell adhesion, inflammatory response, and extracellular exosome. We found that epithelial-mesenchymal transition (EMT) ranked first in the Hallmark pathway enrichment. EMT may potentially be induced by inflammatory cytokines such as CXCL12. IHC confirmed the down-regulation of E-cadherin (CDH1) and up-regulation of CXCL12 in endometriosis tissues.Conclusions: utilizing bioinformatics and patient samples, we provide evidence of EMT in endometriosis. Elucidating the role of EMT will improve the understanding of the molecular mechanisms involved in the development of endometriosis
FIGURE 1. Rhododendron mingii A. Flowing branch. B in Rhododendron mingii (Ericaceae), a new species from Southeast of Yunnan, China
FIGURE 1. Rhododendron mingii A. Flowing branch. B. Close-up view of leaf blade abaxial surface. C. Gynoecium. D. Stamens. E. Opened corolla. F. Habit. (A–E drawn by Y. Luo from the holotype).Published as part of <i>Liu, Zhenwen, Liu, Ende, He, Deming, Ma, Yongpeng & Gao, Lianming, 2023, Rhododendron mingii (Ericaceae), a new species from Southeast of Yunnan, China, pp. 97-104 in Phytotaxa 619 (1)</i> on page 99, DOI: 10.11646/phytotaxa.619.1.5, <a href="http://zenodo.org/record/8425798">http://zenodo.org/record/8425798</a>
FIGURE 2 in Rhododendron mingii (Ericaceae), a new species from Southeast of Yunnan, China
FIGURE 2. Maximum Likelihood tree based on the concatenate sequences of the three DNA barcodes (rbcL, matK and ITS) under the General Time Reversible model. Bootstrap values (>50%) are shown along the clades.Published as part of <i>Liu, Zhenwen, Liu, Ende, He, Deming, Ma, Yongpeng & Gao, Lianming, 2023, Rhododendron mingii (Ericaceae), a new species from Southeast of Yunnan, China, pp. 97-104 in Phytotaxa 619 (1)</i> on page 99, DOI: 10.11646/phytotaxa.619.1.5, <a href="http://zenodo.org/record/8425798">http://zenodo.org/record/8425798</a>
Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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