1,720,980 research outputs found
Purpura de Henoch-Schönlein avec atteinte rénale : analyse des cas pédiatriques traités au CHUV
No full textDescription : Le purpura de Henoch-Schönlein (PHS) est une vasculite à dépôts d’IgA des
petits vaisseaux avec une incidence de 10 à 20 cas/100'000 enfants. Le PHS est responsable
d’une atteinte cutanée, articulaire, digestive, rénale et neurologique. L’atteinte rénale peut se
manifester de manière légère, modérée ou sévère et l’indication au traitement
(néphroprotecteur, corticothérapie ou immunosuppresseur) est à évaluer au cas par cas en
fonction du degré de l’atteinte. Le but de l’étude est d’évaluer le degré de l’atteinte rénale à la
présentation de la maladie chez les enfants avec un diagnostic de PHS et d'analyser l'évolution,
la nécessité d'une biopsie rénale et le traitement prescrit. L'indication pour un traitement
immunosuppresseur est à discuter en fonction de l'évolution de l'atteinte rénale en phase aigue
de la maladie.
Méthode : Cette étude est rétrospective. La taille de l’échantillon repose sur une sélection de
13 patients traités au CHUV entre le 01.01.2010 et le 31.12.2023. Cette étude rétrospective
consiste en l’analyse exploratoire de variables extraites du dossier médical du patient
(Soarian/Archimède) : âge au diagnostic, sexe, symptômes et signes cliniques systémiques,
laboratoires (urée, créatinine et cystatine C ; stix, sédiment, protéines, créatinine et albumines),
biopsie rénale, traitements utilisés, effets secondaires et évolution du traitement et de la maladie.
Les statistiques sont descriptives unidimensionnelles, comme le nombre de patients, la
moyenne, l’écart-type, le minimum, la médiane et le maximum en fonction desquels des
pourcentages pourront être calculés. Les critères d’inclusion sont : tous les enfants atteints de
PHS avec atteinte rénale traités entre le 01.01.2010 et le 31.12.2023 au sein de l’unité de
néphrologie pédiatrique du CHUV ainsi que le consentement spécifique ou général. Les critères
d’exclusion sont : enfants diagnostiqués pour un PHS sans atteinte rénale et absence de
consentement.
Résultats : L’âge médian de la cohorte de 13 patients est de 6,58 ans. Une hypertension
artérielle est observée chez 23% des patients à la présentation de la maladie. Sur le plan urinaire,
15% des patients ont présentés une macrohématurie, 100% une microhématurie et 85% une
protéinurie dans la première année suivant le diagnostic. Les néphropathies légères concernent
deux patients (15,4 %), les néphropathies modérées et sévères concernent chacune cinq patients
(38.5 % chacune) et un patient présente une glomérulonéphrite rapidement progressive (7,7 %).
La prise en charge consiste en une surveillance clinique et biologique lors d’une présence
d’atteinte rénale légère et sans protéinurie. Dans le cas d’une protéinurie pathologique, un
traitement par IEC a été administré. Lors d’une évolution peu favorable, une PBR a été réalisée
et un traitement par prednisone et méthylprednisolone est instauré selon le résultat histologique.
Une atteinte sévère a requis un traitement intensif avec immunosuppression (azathioprine) et
plasmaphérèse.
Conclusion : La microhématurie est un marqueur précoce de l’atteinte rénale et la protéinurie
est un marqueur pronostique prédominant. Cette étude confirme l'efficacité des IEC et des CS
dans la majorité des cas. La PBR précoce est essentielle dans la prise en charge.
L’immunosuppression et la plasmaphérèse contribuent l’amélioration de l’indice d’acuité de la
glomérulonéphrite rapidement progressive. Un suivi néphrologique est crucial jusqu’à un an
après le diagnostic
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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