286 research outputs found
Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework
No full textHelge S. Kragh, Conceptions of Cosmos [Book Review]
No full textHelge S. Kragh, historian of science and prolific author of books (and a member of the editorial board
of this journal), has given us nothing less than a thorough history of cosmology, from biblical myths to
the present view of accelerated expansion. It’s a noble thing to try, and even if it isn’t always perfectly
accurate, Conceptions of Cosmos makes a real contribution to the literature
I remember life as an Estonian at Seabrook
No full textIn this "I remember" memoir, Helge Kangur recalls her Estonian upbringing at Seabrook. She realizes now how fortunate she was to grow up in such a diverse community. The Seabrook Educational and Cultural Center has been soliciting current and past residents of Seabrook Farms for an "I remember" project. Residents are asked to create narratives regarding their experiences at Seabrook Farms. These memories help preserve the history and multi-cultural heritage of Seabrook Farms
Leonardos Bücherliste
No full text„Spera“ schrieb Leonardo da Vinci auf eine Bücherliste. Für welches Buch steht diese Notiz? Warum versuchen Wissenschaftler*innen weltweit, die verlorene Bibliothek Leonardos zu rekonstruieren? Und was erzählt uns die Bibliothek Neues über den berühmten Künstler, Wissenschaftler und Intellektuellen?
Begeben Sie sich mit uns auf eine detektivische Jagd nach den Büchern Leonardo da Vincis, erleben Sie die Explosion kosmologischen Wissens zur Zeit des frühen Buchdrucks und tauchen Sie ein in den geistigen Kosmos Leonardos. Ausgehend von einem kurzen Eintrag in einem seiner Notizbücher vermittelt die Folge „Leonardos Bücherliste“ einen Eindruck vom Reiz und von den Herausforderungen, die die Rekonstruktion von Leonardos Bibliothek darstellen. Sie ermöglicht einen Einblick in die Veränderung, Zirkulation und globale Verbreitung von Wissen zu Leonardos Zeiten und erzählt von Leonardos Kampf mit dem Lateinischen.
Für die Folge haben wir mit Jürgen Renn und Matteo Valleriani vom Max-Planck-Institut für Wissenschaftsgeschichte gesprochen.
Die Podcastfolge erscheint im Kontext der Ausstellung „Leonardos intellektueller Kosmos“, die vom 11. Mai bis 28. Juni 2021 im Dietrich Bonhoeffer-Saal der Staatsbibliothek zu Berlin zu sehen ist. Sie wird vom Max-Planck-Institut für Wissenschaftsgeschichte in Kooperation mit der Staatsbibliothek zu Berlin – Preußischer Kulturbesitz, der NOMIS Foundation, dem Museo Galileo + Istituto e Museo di Storia della Scienza und der Ambasciata d’Italia – Berlino ausgerichtet.Musik:
Kompositionen: Armin Hempel,
Renaissance-Flöte: Anna Fusek.Credits:
„Leonardos Bücherliste“ aus der Reihe „Hinter den Dingen. 5000 Jahre Wissensgeschichte zum Mitnehmen und Nachhören“. Eine Produktion des Projekts „Schauräume des Wissenstransfers“ des DFG-Sonderforschungsbereichs „Episteme in Bewegung“ an der Freien Universität Berlin – das sind: Kristiane Hasselmann, Jan Fusek, Armin Hempel und Katrin Wächter.
Kooperationspartner für diese Folge ist das Max-Planck-Institut für Wissenschaftsgeschichte.
Ein Podcast mit Jürgen Renn, SFB-Mitglied und Direktor des Max-Planck-Instituts für Wissenschaftsgeschichte, und Matteo Valleriani, Forschungsgruppenleiter am Max-Planck-Institut für Wissenschaftsgeschichte.
Stimmen:
Friederike Kroitzsch (Sophie Ruch),
Matthias Dittmer (Leonardo),
Katharina Kwaschik (historische Quellen).
Drehbuch: Jan Fusek;
Ton, Technik, Schnitt: Armin Hempel;
Dramaturgie, Redaktion, Regie: Kristiane Hasselmann, Jan Fusek, Armin Hempel, Katrin Wächter.
Grafik: Martina Hoffmann.
„Hinter den Dingen“ entsteht in Kooperation mit den Staatlichen Museen zu Berlin. Deutschlandfunk Kultur ist Medienpartner.Danke!
Für den Einblick in die spannende detektivische Bücherjagd: Jürgen Renn und Matteo Valleriani.
Für die fachliche Beratung und notwendige Lateinnachhilfe: Helge Wendt und Matthias Grandl.
Für die kollegiale Zusammenarbeit: Lina Schwab, Verena Braun, Stephanie Hood, Teresa Hollerbach, Esther Chen und Sabine Bertram.
Für ihre umfassende Unterstützung in allen Belangen: Stefanie Fröhlich.
An unser Team: Julia Beier, John Damm, Samantha Dittrich und Marie-Theres Wittmann.
Für den guten Sound: André König und Studio Funk
Renaissancen og middelalderen som periodiseringsbegreber:et essay
No full textThe essay discusses the traditional and the occasionally exaggerated use of periodisations in general historical studies. The terms 'the Middle Ages' and 'the Renaissance' have had very long and complicated histories of their own. Of the two terms "the Middle Ages", which was originally a pejorative expression, has appeared to be the strongest of the two, whereas the term 'the Renaissance' has had a much more chaotic history in historiography. During the last 150 years of historical writing and thinking it has gone from the highest success (due to Burchardt 1861) to the deepest downfall (around 1930). The author argues for the preservation of the term 'the Renaissance' for three reasons: (1) The period of the Renaissance coincides with the emergence of the modern, strong power state (from the 14th and 15th centuries onwards) in contrast to the medieval, decentralized, feudal political system, (2) the break-through of the secularisation of science, the humanities, culture and art (during the 15th and 16th centuries), and not in the least (3) the new consciousness of history (the here and now concept!), which arose in Italy in the 15th century, and which broke the millennial, traditional Christian explanation of the course of history
Fitness-AQA Dataset
No full textLargest Fine-grained Exercise Action Quality Assessment Dataset.
Dataset available from the following webpage: https://github.com/ParitoshParmar/Fitness-AQA.
If you find our work useful, please consider citing our ECCV 2022 conference paper that can be found at:
https://link.springer.com/chapter/10.1007/978-3-031-19839-7_7
or
https://arxiv.org/abs/2202.14019
Bibtex file:
@article{parmar2022domain,
title={Domain Knowledge-Informed Self-Supervised Representations for Workout Form Assessment},
author={Parmar, Paritosh and Gharat, Amol and Rhodin, Helge},
journal={arXiv preprint arXiv:2202.14019},
year={2022}
}Only available for non-commercial purposes. Users agree to terms and conditions of usage
Kirsti Aasen: Alle mine kilder
No full textKirsti Aasen: A ll M y Springs. Gyldendal Norsk Forlag, Oslo 1986.Reviewed by Helge Baden NielsenThe title of the book are the first words of one of Grundtvig’s hymns. The reviewer sees this essay collection by a Norwegian woman minister first and foremost as an expression of the new interest in Grundtvig in Norway, as was proved by the establishment in 1983 of a special Norwegian branch of the Grundtvig Society. According to Kirsti Aasen this takes its origin in the liberation, under Grundtvig’s inspiration, from the pietistic view of Christianity in Norway. In her own case she discovered that Christianity could easily be combined with love of the Norwegian countryside and the life of the people. The author was born in .sterdalen, studied theology at Oslo University, and is now rector of a parish in Oslo
The role of monocyte phenotype and steroid-related gene expression in major depressive disorder
No full textBackground: Inflammation has been associated with major depressive disorder (MDD). Meta-analytic evidence has shown increased levels of circulating pro-inflammatory cytokines in groups of patients with MDD. However, little is known about the cellular source of these inflammatory signals. Recent studies have suggested that innate and adaptive immunity may be differentially affected in MDD. Neuroendocrine pathways tightly regulate cellular inflammation via glucocorticoids, such as cortisol. While some studies have found neuroendocrine disturbances in MDD, it has remained unclear whether impairments in glucocorticoid signalling are cell-specific. Therefore, we interrogated phenotype and glucocorticoid signalling of key innate (monocytes) and adaptive (T cells) immune cell populations in patients with MDD and healthy controls (HC).
Methods: 35 well-characterized antidepressant-free patients with MDD and HC individually matched for age, sex, smoking status and body mass index were enrolled. All participants were free of immunomodulatory medications or significant medical illness and non-pregnant. Immunophenotyping was performed by flow cytometry following established guidelines. Cell-specific steroid signalling was determined by mRNA expression of pre-receptor regulation (11β-hydroxysteroid dehydrogenase type 1 [11β-HSD1]), receptor expression (glucocorticoid [GR] and mineralocorticoid receptor [MR]), and its main downstream target (glucocorticoid-induced leucine-zipper [GILZ]). Salivary cortisol (collected on two consecutive days at 8 a.m. and 10 p.m.) and serum levels of IL-6, IL-1ß and TNF-α were analysed with ELISA.
Paired-samples t-tests were used for continuous variables and McNemar’s Test for dichotomous variables. Repeated-measures ANOVA was used for cortisol values. Effects sizes were calculated as Hedges’ g.
Results: In patients with MDD, we observed a shift in monocyte repertoire towards elevated frequencies of non-classical monocytes (p 0.05). Furthermore, monocytes but not T cells from patients with MDD showed lower expression of GR (p = 0.018; Hedges’g = 0.21) and GILZ (p = 0.045; Hedges’g = 0.39), indicative of steroid resistance. Finally, altered monocyte phenotype and steroid gene expression occurred against the backdrop of unchanged salivary cortisol (p = 0.32) and serum cytokine levels (ps > 0.05).
Conclusion: Our results suggest that in MDD regulatory mechanisms of inflammation are affected in a cell-specific manner. More specifically, we found a shift towards a pro-inflammatory phenotype and gene expression consistent with steroid resistance that was restricted to monocytes and occurred without neuroendocrine alterations. Our results could outline avenues for tailored cell-specific treatments to target aberrant inflammation in MDD.Entzündliche Prozesse stehen mit der Pathophysiologie von Depression (MDD) in Verbindung. Meta-Analysen deuten auf erhöhte Spiegel von zirkulierenden pro-inflammatorischen Zytokinen in Patientengruppen hin. Bisher ist nur wenig über den zellulären Ursprung dieser entzündlichen Signale bekannt. Jüngere Untersuchungen konnten zeigen, dass adaptive und angeborene Immunität bei MDD differentiell beeinträchtigt sein könnte. Glukokortikoide wie Cortisol sind potente neuroendokrine Regulatoren von Inflammation. Eine veränderte neuroendokrine Regulation ist bei Patienten mit MDD beschrieben worden, allerdings ist unklar, ob diese neuroendokrinen Veränderungen zell-spezifisch auftreten. Das Ziel dieser Arbeit ist es, Phänotyp sowie Steroidregulation von Monozyten und T-Zellen, den wichtigsten Zellpopulationen von angeborenem und erworbenem Immunsystem, bei Patienten mit MDD und gesunden Kontrollen (GK) zu untersuchen.
Methoden: 35 Antidepressiva-unmedizierte Patienten mit MDD und 35 GK (individuell parallelisiert nach Alter, Geschlecht, Raucherstatus und Body-Mass-Index) wurden für die Studie rekrutiert. Alle Probanden waren frei von immunmodulatorischer Medikation, ohne signifikante medizinische Begleiterkrankungen und nicht-schwanger.
Immunophänotypisierung wurde mithilfe von Durchflusszytometrie gemäß etablierter Standards durchgeführt. Zell-spezifische Steroidregulation wurde anhand der mRNA-Expression auf Ebene von prä-Rezeptor- (11β-hydroxysteroid dehydrogenase type 1 [11β-HSD1]), Rezeptor- (Glukokortikoid- [GR] und Mineralokortikoidrezeptor [MR]) sowie post-Rezeptor-Ebene (glucocorticoid-induced leucine-zipper [GILZ]) bestimmt. Speichel-Cortisol zweier konsekutiver Tage (8:00 und 22:00 Uhr) sowie IL-6, IL-1ß und TNF-α-Serum-Spiegel wurden mittels ELISA analysiert. Kontinuierliche Variablen wurden mittels des t-Tests für verbundene Stichproben, dichotome Variablen mit McNemar’s Test und Speichel-Cortisol mit einer messwiederholten Varianzanalyse ausgewertet. Hedges’ g wurde als Maß der Effektstärke berechnet.
Ergebnisse: Bei Patienten mit MDD zeigte sich eine signifikante Verschiebung des Monozyten-Repertoire hin zu einer erhöhten Frequenz von nicht-klassischen Monozyten (p 0.05). In Einklang hiermit zeigten nur Monozyten, nicht aber T-Zellen, von Patienten mit MDD geringere mRNA-Level von GR (p = 0.018; Hedges’ g = 0.21) und GILZ (p = 0.045; Hedges’ g = 0.39) als Monozyten von Kontrollen, was auf Steroidresistenz hindeutet. Diese Veränderungen waren unabhängig von Speichel-Cortisol- (p = 0.32) und Serum-Zytokin-Spiegeln (ps > 0.05).
Conclusio: Unsere Ergebnisse deuten darauf hin, dass die Regulation von Inflammation bei Patienten mit MDD auf zell-spezifische Weise beeinträchtigt ist. Es zeigte sich eine Verschiebung hin zu einem pro-inflammatorischen Phänotypen gekoppelt mit einer Monozyten-spezifischen Genexpression, die mit Steroidresistenz konsistent ist. Diese Veränderungen traten bei depressiven Patienten ohne Erhöhung der Speichel-Cortisol-Spiegel auf. Diese Ergebnisse könnten Hinweise für zukünftige zell-spezifische Behandlung von entzündlichen Prozessen im Rahmen von MDD liefern
Recommended from our members
The Rise and Development of Contemporary European Big Band Writing: An Analysis of Composers Peter Herbolzheimer, George Gruntz, Kenny Wheeler, Helge Sunde, and Florian Ross
No full textIt has been argued that a distinctive European big band sound began to emerge in the second half of the 20th century and has continued to develop over the following decades. As of this writing, however, only one book – in German – attempts to address the idea of a contemporary European big band approach, and no known publications are extant in the English language that specifically analyze works solely of contemporary European big band composers. With this in mind, this essay explores the music, compositions, and arranging styles of the following influential contemporary European composers: Peter Herbolzheimer, George Gruntz, Kenny Wheeler, Helge Sunde, and Florian Ross. The author identifies specific techniques, compositional trends, and influences that make these writers unique to the European continent. These findings are then applied in the creation of three extended jazz compositions totaling approximately 35 minutes in length and the author enumerates how these techniques and concepts were incorporated.</p
Grundtvigs symbolverden. Af Helge Toldberg
No full textHelge Toldberg: Grundtvigs symbolverden (Grundtvig s Universe of Symbols), Skrifter udgivet af Grundtvig-Selskabet II. Copenhagen, 1950. Grundtvig’s copious use of images and symbols has given him the reputation of being an obscure and often incomprehensible writer. Only a few research students have ventured to approach Grundtvig on this side of his nature, whether it is a question of the exhaustive interpretation of particular works or of reading “ right through” his whole literary output for the purpose of establishing the underlying connections in his world of ideas and symbols. Dr. Helge Toldberg belongs to the latter group. In his book (the thesis for his Doctorate at the University of Copenhagen in 1950) he has undertaken the task of analysing the symbols employed by Grundtvig, in the belief that the frequent use of the same symbols by an author has a significance of its own, apart from the context in which they appear. The consequence of the acceptance of this principle by Dr. Toldberg is that in his study of Grundtvig’s writings the particular text is of minor interest; it is only in the comparatively few cases where the symbol constitutes its whole content that an analysis of any particular text is given. But, apart from this, the author’s method is the opposite of the genetical one. He is emphatically a systematiser and “ structuralist”, who works with clear concepts and wide ranges, and who embodies his results in definite schematic forms. In his book he attempts the immense task of finding his way down through the outward forms of Grundtvig’s literary output to its omnipresent foundation, its substratum, i. e., Grundtvig’s fundamental attitude to life or fundamental philosophy, and to the symbols employed by Grundtvig to express this fundamental philosophy. This substratum is determined by religious rather than by aesthetic factors, and Grundtvig’s choice of symbols is determined in great measure by this circumstance. Dr. Toldberg divides Grundtvig’s symbols into two groups: the symbols of life and faith which are closely connected with the substratum, and the legendary and traditional symbols taken from mythology and history which are more arbitrary and independent of the substratum. But even the last-named group of symbols is also strictly determined by the substratum, and the author’s division must therefore be regarded as a weakness ind the book and as serving an expository rather than a descriptive purpose. And indeed in practice he does not invariably keep to the sharp division he himself has made. Dr. Toldberg also makes use of the following fundamental concepts (borrowed from John Stuart M ill) : denotation, i. e., interpretation, direct signification, and connotation, i. e., connected or subsidiary ideas, the associative element. The principle of denotation is posited as the distinguishing mark of the poetry whose strength — as well as its limitations — lies in definite meanings of words, in classical clarity (typical author: Virgil). If a poem is rich in connotations, it may be characterised as romantic (in the wider sense); a poem of this kind aims first and foremost not at clarity but at plenitude (typical authors: Shakespeare, Grundtvig). Grundtvig, who despised Virgil and loved Shakespeare, is romantic in the sense that his symbolism points away from that which symbolises towards that which is symbolised (in contradistinction to that of the classical writers). Dr. Toldberg’s interpretation of Grundtvig is thus principally concerned with the subsidiary meanings which accompany the symbols, and here his philological and mythological scholarship achieves many triumphs. Thanks to an excellent index, the book can be used as a regular reference book for the interpretation of Grundtvig. The constant and the changing elements in the connotations are acutely observed, and where the symbols of life and faith are in question we are shown the coincidence between the changes in their connotations and the mutations in Grundtvig’s religious experience. The wide survey taken by Dr. Toldberg and his sense for the recurrent symbols as such can, however, cause him sometimes to overlook obvious connections and details within a particular text. From the point of view of pure literary scholarship his method can become dangerous in its denial of the organic microcosm of the particular work taken in isolation. But his system gives his grandly-conceived attempt at interpretation a firm structure which is admirable and instructive. However, the fact that the distinction between connotations and denotations may sometimes appear to be effaced raises a problem which the author has not recognised or discussed. Many of Grundtvig’s connotations really derive their character from what might be called “ private denotations” . A recognition of this problem could have given occasion for fruitful aesthetic and critical reflections. Does not a great deal of Grundtvig’s writing show traces of stiffening into a routine of conventional phraseology? And does not the recognition of this create the background for an even higher appreciation of his finest passages which reach the heights of inspiration? In the valuable chapters on Grundtvig’s symbolic language and symbolic vision (P. 37—72) two central concepts in Grundtvig’s writing are brought to light: “ spejl” = “mirror” (or “ spejling” = “mirroring”), and “ gaacfe” = “mystery” . Man (i. e. Grundtvig) must apprehend synthetically, not analytically. And the synthesis which must be apprehended everywhere is “God’s purpose in the historical and mythological context” (P. 64). The world, history and human life mirror the Divine Being, and the poet’s work is to interpret this mirroring and nothing else. Thus Grundtvig regards science as being in subordination to faith, which must reject every scientific interpretation that is incompatible with this. (Grundtvig was therefore opposed to the astronomical theories of Copernicus.) For Grundtvig existence, history, and the origin of Christianity are a series of mysteries, which can only be solved with the help of the Christian faith. The task is the interpretation of visions, and this is only possible through adopting a prophetic standpoint in relation to present and past events (P. 68). Words like “wondrous” , “wonderful” and “ to illumine” are therefore favourite words for Grundtvig. Dr. Toldbergs book is written in an exact and technical scholarly language which makes it difficult for non-specialists, and indeed for specialists as well. There seems to be something tragic in the fact that while the book’s terminology and method are addressed to readers who may be regarded as being out of touch with Grundtvig’s world of ideas, its content is concerned in great measure with what is most centrally Grundtvigian! Dr. Toldberg has begun by discussing the symbols of life and faith, and has afterwards discussed the traditional historical and mythological symbols. To have discussed them in the reverse order would have been better, and would have led the reader in clearer fashion and along an ascending path into the centre of Grundtvig’s spiritual world. The long section about legendary and traditional symbols is the most imposing from the point of view of scholarship, with its wealth of observation and power of combination. But the deepest perspectives are to be found in the section about the symbols of life and faith. The notes with which the book is liberally provided contain a wealth of information and suggestions for further study
- …
