1,720,960 research outputs found
Modulation of Inflammation Mediated Cancer by Selected Dietary Components and their Mechanism of Action Using In Vitro and In Vivo Models.
No full textAntioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers.
No full textOxidative stress and inflammation are important critical factors that are implicated in almost all life style disorders
such as diabetes, cardiovascular disease, ulcer and cancer. Current study aimed at isolation and characterization
of a furanocoumarin from Bael (Aegle marmelos L.) fruit that can modulate both oxidative stress and
inflammation effectively. Ethyl acetate extract of Bael fruit (EAFB) was subjected to HPLC for identification,
purified and characterized using FTIR, NMR and ESI-MS analysis. Predominant peak of EAFB at RT 12.54 min on
HPLC was identified as marmelosin with molecular weight of m/z ∼ 271.2. Marmelosin was evaluated for
antioxidant, antiproliferative, apoptotic, cancer (Tyrosinase & Galectin-3) and immunomodulatory (NO, TNF-α)
potentials employing standard assay systems. Marmelosin possessed potent antioxidant activity with IC50 of ∼
15.4 ± 0.32 μM as opposed to standard - gallic acid (IC50 1.1 ± 0.08 μM), antiproliferative activity with IC50 of
∼ 6.24 ± 0.16 μM as opposed to deferoxamine (∼10.8 ± 0.28 μM) and protected cells against cellular/DNA
damage. Anti-inflammatory property was evident with significant reduction in the release of NO (∼3.9 fold) and
TNF-α (∼3.4 fold), a pro-inflammatory cytokine, in addition to the inhibition of NFκB (∼2.7 fold), a transcription
factor in Raw 264.7 cells. Marked down regulation of galectin-3 (∼5.5 folds) and tyrosinase (∼11.1
folds) by gene expression analysis substantiated by tyrosinase inhibition (IC50 – 20.3 ± 1.26 μM Vs. Kojic acid –
IC50 – 24.1 ± 1.41 μM) and molecular docking studies strengthened the cancer modulatory property of marmelosin.
In addition, marmelosin induced apoptotic bodies, chromatin condensation and nulcear blebbing in
Raw 264.7 cells commending the apoptotic effect of marmelosin. Marmelosin thus displayed potential multipotent
antioxidant, anti-inflammatory and anticancer properties via TNF-α mediated Akt signaling pathway
A xylorhamnoarabinogalactan I from Bael (Aegle marmelos L.) modulates UV/DMBA induced skin cancer via galectin-3 & gut microbiota
No full textMetastasis, inflammation and uncontrolled melanogenesis triggered by cancer cells via galectin-3, cytokines and
dysregulated tyrosinase have been implicated in aggressive skin cancer condition. Cyclophosphamide and kojic
acid although are used as immunomodulator and tyrosinase inhibitor respectively, the side effects posed by them
warranted the need for safe alternatives. In the current study, we identified a, ∼91 kDa xylorhamnoar-
abinogalactan I pectic polysaccharide from Bael (Aegle marmelos L.) - BAPP1 with constituting sugars - →4)β-D-
Xylp-(1 → 3)-D-GalpA-(1→ xylogalacturonan and →4)α-D-GalpA-(1–2)-α-L-Rhap-(1→ rhamnogalacturonan
structure with →5)α-L-Araf-(1→;→3)α-L-Araf-(1→ arabinan and →1)β-D-Galp-(4→ galactan as side chains.
BAPP1 could potentially inhibit galectin-3 at MIC of 2.98 µg/mL; immunoregulatory cytokines IL10/IL17 (∼3
folds) and tyrosinase (IC50 of 28.0 ± 3.61 µg/mL), which are the key targets for the control of skin cancer
(Scheme 1). Results were substantiated by both in vitro and UV/DMBA induced skin cancer models together with
gene analysis. Xylorhamnoarabinogalactan I showed improved gut microbiota status in experimental animals.
BAPP1 thus may find potential against metastasis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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