7 research outputs found
Unusual presentation of rare primary lymphoma of bone
No full textPrimary bone lymphoma is a distinct disease. It represents only 3% of all malignant bone tumours and less than 1% of non-Hodgkin's lymphoma. It is essential to differentiate it from other tumours because of its good prognosis. We report a case of 45 years old male who presented one year ago with a painful left arm. His symptoms started after minimal trauma. The pain persisted for 6 months and became severe. It was managed by traditional medicine a practitioners who diagnosed it as a shoulder's sprain and did several massages sessions. The patient had worsening of his pain. On physical examination, shoulder movements were painful. Left arm was entirely swell. Superficial lymph nodes were not enlarged. The X-ray radiograph of the left upper extremity showed a fracture of the proximal humerus and large condensation lesion of the all humerus. Patient was posted for an open biopsy which revealed a primary diffuse large B cell lymphoma. Flow cytometric immunophenotyping showed positivity for CD10, CD20 and BCL6 and negativity for CD5, MUM1 and BCL2. Bone marrow and cerebrospinal examinations were normal. Contrast enhanced computed tomography of chest and abdomen failed to show evidence of any lymphomatous deposits. The patient was treated with chemotherapy including cyclophosphamide, doxorubicin, vincristine, and prednisolone with a good clinical response. He has been lost to follow up after five cycles of chemotherapy because of financial problem. The diagnostic study should begin with simple Xray but adequate biopsies for histologic examination remain the standard in diagnosis.Pan African Medical Journal 2015; 2
Épidémiologie des cancers pris en charge en oncologie médicale à l’hôpital militaire d’Antananarivo, Madagascar
No full textRisk factors for recurrence of invasive breast cancer after primary surgery in patients followed at the medical oncology and palliative care department of Soavinandriana Hospital Center
No full textBackground: Breast cancer mortality is often linked to recurrence or progression. This study aims to identify and describe the risk factors for recurrence in invasive breast cancers after primary surgery.
Methods: A case-control study was conducted from January 1, 2017, to December 31, 2023.
Results: The study included 55 cases and 55 controls. Identified risk factors for recurrence include age under 50 (OR 3.21; p=0.005), partial mastectomy (OR 7.7; p=0.001), vascular emboli or perineural invasion (OR 2.85; p=0.019), poor resection margin (R+) (OR 16.36; p=0.00), >25% lymph node invasion (OR 5.33; p=0.002), capsular rupture (OR 8.78; p=0.000), CA 15-3 >30 U/ml (OR 6.66; p=0.01), and lack of radiotherapy (OR 3.39; p=0.002) or chemotherapy (OR 4.07; p=0.001) as adjuvant treatments.
Conclusions: The identified risk factors align with those in existing literature and should be considered to enhance breast cancer treatment
ABO blood group in Malagasy patients with cancer: which group predominates
No full textThe blood group of Malagasy patients with cancer have never been the subject of previous publications. Our objective was to determine the blood group of Malagasy patients with cancer followed in the Medical Oncology Unit of the Soavinandriana Teaching Hospital, Antananarivo. This was a one-year retrospective study (November 2012 to October 2013) in patients over the age of 15 with histological or pathological evidence of their cancer. One hundred and thirty of the 258 patients identified had an ABO blood group determination (50.39%). Among these 130 patients, 114 patients (87.69%) had solid tumors and 16 patients (12.31%) had hematologic malignancies. Thirty seven (28.49%) patients were transfused and 93 (71.54%) not transfused. There were 57 men and 73 women (sex ratio = 0.78), the average age was 55.11 +/- 14.76 years. With regard to their blood group, 52 patients (40%) were blood group B, 44 (33.84%) group O, 27 (20.76%) group A and 7 (5.38%) group AB. The order of blood group frequency of cancer patients in our series differs from other studies. This study has allowed us to know the proportion of each blood group in our Unit and thus help us in the management of stocks of labile blood products in our hospital
Epidemioclinical aspects of breast cancer in women under 35 years at the oncology and palliative care department of Soavinandriana Hospital
No full textBackground: Breast cancer is rare among women under 35 years, but its incidence is increasing, particularly in low-resource settings. Young patients often present with aggressive disease and delayed diagnosis. This study aimed to describe the epidemioclinical features of breast cancer in this population.
Methods: A retrospective descriptive study was conducted from January 2014 to September 2024 at the oncology and palliative care department of Soavinandriana Hospital, Madagascar. 38 women under 35 years old with histologically confirmed breast cancer were included.
Results: Among 2,087 breast cancer cases, 38 (1.82%) involved women under 35. The mean age was 30.7 years. Most patients were pauciparous (50%), had breastfed (73.7%), were non-smokers (81.6%), and had no family history of breast or ovarian cancer (76.3%). The upper outer quadrant was the most common tumor site (34.2%). Invasive carcinoma of no special type was predominant (78.9%). Grade II and III tumors accounted for 65.8%. More than 50% of patients were diagnosed at an advanced stage (IIB or higher). Immunohistochemical and staging data were frequently incomplete due to limited diagnostic resources.
Conclusions: Breast cancer in young Malagasy women is uncommon but presents aggressively and at advanced stages, underscoring the need for early detection strategies. Improved diagnostic access and tailored screening programs are essential
Aspects cliniques des cancers bronchopulmonaires primitifs au service d’oncologie du CHUA-HUJRA Antananarivo
No full textLe retard de diagnostic des cancers broncho-pulmonaires est l'une des sources du retard de leur prise en charge dans les pays en développement. A notre connaissance, l'aspect clinique des cancers broncho-pulmonaires au Centre Hospitalier Universitaire d'Antananarivo-Hôpital Universitaire Joseph Ravoahangy Andrianavalona (CHUA-HUJRA) n'a jamais été étudié. L'objectif était de décrire les aspects cliniques des cancers bronchopulmonaires primitifs dans le plus grand centre de cancérologie de Madagascar. C'est une étude rétrospective et descriptive des patients atteints de cancers broncho-pulmonaires primitifs vus au service d'oncologie du CHUA-HUJRA du 1er janvier 2008 au 31 décembre 2013. Nous avons recensé 101 patients (80 hommes et 21 femmes). Les circonstances de découverte sont principalement la toux chronique (n=29), la dyspnée (n=16) et l'association d'une hémoptysie à la toux chronique (n=12). Soixante et onze patients avaient un index de performans status ? à 2 au moment du diagnostic. On a retrouvé des bacilles de Koch actives dans le crachat de deux patients. Le délai moyen entre l'apparition des premiers signes et la première consultation était de 11 mois. Le délai moyen entre la première consultation et le diagnostic anatomopathologique était de 3 mois. Le cancer broncho-pulmonaire peut avoir des manifestations cliniques non spécifiques parfois trompeuses qui peuvent retarder leur prise en charge. De ce fait, il doit être recherché devant tout signe respiratoire persistant. Par ailleurs, le délai de prise en charge pré-hospitalière et hospitalière de ces cancers doit être amélioré.Pan African Medical Journal 2015; 2
First results of hormone receptors' status in Malagasy women with invasive breast cancer
No full textInternational audienceINTRODUCTION:Breast cancer is the most common malignancy tumor amongst Malagasy women registered at the pathology unit of the "Institut Pasteur de Madagascar". In Madagascar, there is no laboratory practicing hormone receptors' status on these tumors. Until now no study about hormone receptors' status of Malagasy women with invasive breast cancer was performed. So it will be the first study talking about this topic. The aim of this study was to determine hormone receptors' status in Malagasy women with invasive breast cancer.METHODS:This retrospective and descriptive study was based on patients' medical files from 2009 to 2011. It included all invasive breast cancer diagnosed in Malagasy women at the pathology laboratory located at the "Institut Pasteur de Madagascar", in Antananarivo. Along this period this laboratory has sent paraffin blocks of invasive breast carcinoma in two pathological laboratories in France.RESULTS:We collected 77 cases of invasive breast cancer along this period. The mean age was 48.8 +/- 10.7, ranging from 26 years to 70 years. There were 46.8 % (n = 36) women with progesterone receptor positive (PR+), 53.2 % (n = 41) with progesterone receptor negative (PR-). For the estrogen receptor, 61.0 % (n = 47) were positive and 36.4 % (n = 28) were negative. ER+/PR+ represented 44.2 % (n = 34); ER-/PR- 33.8 % (n = 26); ER +/ PR- 16.8 % (n = 13); ER-/PR+ and ER-/PR- represented respectively 2.6 % (n = 2).CONCLUSION:Patients in our study had more important rate of ER-, PR- and a less important rate of ER+/PR+, PR+. These results suggest that more study related to Hormone Receptor profile should be conducted in Malagasy women with breast cancer
