1,721,188 research outputs found
Cognitive Enhancement in Psychiatric Disorders
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Head stabilization in a humanoid robot: models and implementations
No full textNeuroscientific studies show that humans tend to stabilize their head orientation, while accomplishing a locomotor task. This is beneficial to image stabilization and in general to keep a reference frame for the body. In robotics, too, head stabilization during robot walking provides advantages in robot vision and gaze-guided locomotion. In order to obtain the head movement behaviors found in human walk, it is necessary and sufficient to be able to control the orientation (roll, pitch and yaw) of the head in space. Based on these principles, three controllers have been designed. We developed two classic robotic controllers, an inverse kinematics based controller, an inverse kinematics differential controller and a bio-inspired adaptive controller based on feedback error learning. The controllers use the inertial feedback from a IMU sensor and control neck joints in order to align the head orientation with the global orientation reference. We present the results for the head stabilization controllers, on two sets of experiments, validating the robustness of the proposed control methods. In particular, we focus our analysis on the effectiveness of the bio-inspired adaptive controller against the classic robotic controllers. The first set of experiments, tested on a simulated robot, focused on the controllers response to a set of disturbance frequencies and a step function. The other set of experiments were carried out on the SABIAN robot, where these controllers were implemented in conjunction with a model of the vestibulo-ocular reflex (VOR) and opto-kinetic reflex (OKR). Such a setup permits to compare the performances of the considered head stabilization controllers in conditions which mimic the human stabilization mechanisms composed of the joint effect of VOR, OKR and stabilization of the head. The results show that the bio-inspired adaptive controller is more beneficial for the stabilization of the head in tasks involving a sinusoidal torso disturbance, and it shows comparable performances to the inverse kinematics controller in case of the step response and the locomotion experiments conducted on the real robot
Penetration of the Internet into the Japanese society
No full textJapan experienced a rapid penetration of the Internet from the mid-1990s. While the Internet in the Japanese social context has many aspects in common with other advanced countries, there are some phenomena quite unique to Japan. The market penetration of personal computers, drastic devaluation of telecommunication costs, and construction of the broadband access network constitute universally shared background for the growth of the Internet. Meanwhile, the role of mobile phones in Japan, for example, is different from that in American or European contexts. Our discussion consists of three main parts. First, we depict an outline of the present penetration of the Internet in the Japanese market. Second, some recent changes in economic activities are reviewed from the point of networking technology. And, lastly, some examination and speculation are given for the role of mobile phones, which might be interpreted as an aspect quite unique to the Japanese context.La diffusion d'Internet dans la société japonaise. Le Japon a connu une diffusion rapide de l'Internet depuis le milieu des années 1990. Après avoir présenté le marché japonais, cet article présentera quelques récents changements dans des activités économiques utilisant les technologies de communication. Enfin, sera examine le rôle de la téléphonie mobile dans la diffusions d’Internet au Japon, rôle différent de celui joué en Amérique ou en Europe.Arai Yoshio, Hashimoto Kenji, Yamada Harumichi. Penetration of the Internet into the Japanese society. In: NETCOM : Réseaux, communication et territoires / Networks and Communication Studies, vol. 16 n°3-4, december 2002. Internet Development in Asia / Le développement d'Internet en Asie. pp. 135-154
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants.
Full text linkAbnormal patterns of HPA axis activation, under basal conditions and in response to stress, are found in individuals with schizophrenia and bipolar disorder. Altered glucocorticoid receptor (GR) mRNA and protein expression in the dorsolateral prefrontal cortex (DLPFC) in psychiatric illness have also been reported, but the cause of these abnormalities is not known. We quantified expression of GR mRNA transcript variants which employ different 5' promoters, in 35 schizophrenia cases, 31 bipolar disorder cases and 34 controls. We also explored whether sequence variation within the NR3C1 (GR) gene is related to GR mRNA variant expression. Total GR mRNA was decreased in the DLPFC in schizophrenia cases relative to controls (15.1%, p<0.0005) and also relative to bipolar disorder cases (8.9%, p<0.05). GR-1B mRNA was decreased in schizophrenia cases relative to controls (20.2%, p<0.05), while GR-1C mRNA was decreased in both schizophrenia and bipolar disorder cases relative to controls (16.1% and 17.2% respectively, both p<0.005). A dose-dependent effect of rs10052957 genotype on GR-1B mRNA expression was observed, where CC homozygotes displayed 18.4% lower expression than TC heterozygotes (p<0.05), and 31.8% lower expression than TT homozygotes (p<0.005). Similarly, a relationship between rs6190 (R23K) genotype and GR-1C expression was seen, with 24.8% lower expression in GG homozygotes than GA heterozygotes (p<0.01). We also observed an effect of rs41423247 (Bcl1) SNP on expression of 67 kDa GRα isoform, the most abundant GRα isoform in the DLPFC. These findings suggest possible roles for the GR-1B and GR-1C promoter regions in mediating GR gene expression changes in psychotic illness, and highlight the potential importance of sequence variation within the NR3C1 gene in modulating GR mRNA expression in the DLPFC
Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice.
Full text linkThe cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactive constituent of cannabis, Δ(9)-tetrahydrocannabinol. Here we investigated whether Nrg1 TM HET mice respond differently to CBD and whether CBD reverses schizophrenia-related phenotypes expressed by these mice. Adult male Nrg1 TM HET and wild type-like littermates (WT) received vehicle or CBD (1, 50 or 100 mg/kg i.p.) for 21 days. During treatment and 48 h after withdrawal we measured behaviour, whole blood CBD concentrations and autoradiographic receptor binding. Nrg1 HET mice displayed locomotor hyperactivity, PPI deficits and reduced 5-HT(2A) receptor binding density in the substantia nigra, but these phenotypes were not reversed by CBD. However, long-term CBD (50 and 100 mg/kg) selectively enhanced social interaction in Nrg1 TM HET mice. Furthermore, acute CBD (100 mg/kg) selectively increased PPI in Nrg1 TM HET mice, although tolerance to this effect was manifest upon repeated CBD administration. Long-term CBD (50 mg/kg) also selectively increased GABA(A) receptor binding in the granular retrosplenial cortex in Nrg1 TM HET mice and reduced 5-HT(2A) binding in the substantia nigra in WT mice. Nrg1 appears necessary for CBD-induced anxiolysis since only WT mice developed decreased anxiety-related behaviour with repeated CBD treatment. Altered pharmacokinetics in mutant mice could not explain our findings since no genotype differences existed in CBD blood concentrations. Here we demonstrate that Nrg1 modulates acute and long-term neurobehavioural effects of CBD, which does not reverse the schizophrenia-relevant phenotypes
Low Dose Prenatal Ethanol Exposure Induces Anxiety-Like Behaviour and Alters Dendritic Morphology in the Basolateral Amygdala of Rat Offspring
No full textPrenatal exposure to high levels of alcohol is strongly associated with poor cognitive outcomes particularly in relation to learning and memory. It is also becoming more evident that anxiety disorders and anxiety-like behaviour can be associated with prenatal alcohol exposure. This study used a rat model to determine if prenatal exposure to a relatively small amount of alcohol would result in anxiety-like behaviour and to determine if this was associated with morphological changes in the basolateral amygdala. Pregnant Sprague Dawley rats were fed a liquid diet containing either no alcohol (Control) or 6% (vol/vol) ethanol (EtOH) throughout gestation. Male and Female offspring underwent behavioural testing at 8 months (Adult) or 15 months (Aged) of age. Rats were perfusion fixed and brains were collected at the end of behavioural testing for morphological analysis of pyramidal neuron number and dendritic morphology within the basolateral amygdala. EtOH exposed offspring displayed anxiety-like behaviour in the elevated plus maze, holeboard and emergence tests. Although sexually dimorphic behaviour was apparent, sex did not impact anxiety-like behaviour induced by prenatal alcohol exposure. This increase in anxiety - like behaviour could not be attributed to a change in pyramidal cell number within the BLA but rather was associated with an increase in dendritic spines along the apical dendrite which is indicative of an increase in synaptic connectivity and activity within these neurons. This study is the first to link increases in anxiety like behaviour to structural changes within the basolateral amygdala in a model of prenatal ethanol exposure. In addition, this study has shown that exposure to even a relatively small amount of alcohol during development leads to long term alterations in anxiety-like behaviour
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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