4,637 research outputs found
Authors’ response to the specious “Comment on the paper, on Cattaneo-Christov heat flux model for Carreau fluid flow over a slendering sheet, Hashim, Masood Khan, Results in Physics, 7 (2017) 310–319”
No full textOur intention in this write-up is to give a reply for the specious comment of Asterios Pantokratoras on the paper “On Cattaneo-Christov heat flux model for Carreau fluid flow over a slendering sheet, Hashim and Masood Khan, Results in Physics, 7 (2017) 310–319 (Hashim and Masood Khan, 2017)”. The authors talked about each of those comments in detail. In brief, the authors do not comply with those specious comments made by Asterios Pantokratoras (2017)
Numerical study of transient response in amperometric and potentiometric glucose biosensors
No full textBiosensors are indispensable tools for continuous monitoring of key analytes, such as glucose, in chronic disease management. This thesis focuses on enzyme-immobilized redox polymer biosensors, leveraging reaction-diffusion partial differential equations (PDEs) to bridge the gap between theory and practical applications for biosensor design.A transient numerical scheme in MATLAB was used to solve coupled non-linear PDEs, capturing the dynamic behavior of enzyme-membrane systems. Verification was achieved by comparing steady-state analytical solutions with numerical outputs, while Case diagrams were used to identify different kinetic and transport regimes. Experiments with deflavinated enzymes provided a means to validate our model by systematically manipulating key parameters. Simulation results were compared with experimental data, revealing key insights into transient enzyme-membrane interactions.The study also investigated tubular flow electrodes, revealing the dependence of steady-state amperometric responses on solution viscosity under flow conditions. Experimentally obtained chronoamperograms were fitted to numerically solved dynamic simulations, confirming the model's predictive capabilities. Novel boundary conditions were also proposed to simulate potentiometric biosensors, broadening the scope of this work beyond amperometric sensing.Animations visualizing concentration profiles and system responses offer a deeper understanding of transient and steady-state behaviors. These insights can contribute to the optimization of biosensor performance, including sensitivity, dynamic range, and response time, advancing the development of robust and accurate glucose monitoring technologies
Dataset in support of thesis titled "Numerical Study of Transient Response in Amperometric and Potentiometric Glucose Biosensors"
No full textThis dataset contains:
1-.gif files containing animations for the reaction-diffusion simulations for different input variables. Animation Created in MATLAB R2022a.
2-.gif files containing animations for the 3D Case diagram created in Wolfram Mathematica 13.1.
3-.m files containing MATLAB code for the readers to reproduce the simulations. Files titled "ND_PS_EK_PencilE_SubStep_v3.mlx" and "Fit_PS_PencilE_Caller.mlx" are associated with Chapter 4. </span
Optimization of amperometric biosensor design using mathematical modelling and simulation
No full text425 million adults suffered from diabetes globally in 2017 with a predicted increase of 50 % by 2045. One good way to reduce the impact of this disease is by continuously monitoring the glucose levels of the patient using analytical devices. We are trying to research a specific case of such analytical devices i.e., enzyme immobilized redox polymer layered biosensors for continuous glucose monitoring using mathematical models. We have applied a transient numerical scheme using the commercial software MATLAB to solve the mathematical model. Mathematical verification of the system has been carried out by comparing our numerical results to steady state analytical solutions. We are trying to understand the transient regimes before the system reaches steady state. A novel validation procedure has been devised using the deflavinated enzyme to change the kinetic parameters in the physical system. The response will be compared with the simulated results.We also present an optimization of the physical system by using engineering constraints. This work has the potential to better explain the working of analytical devices and improve their working. <br/
Modelling enzyme electrodes – what do we learn and how is it useful?
No full textThere has been an enormous increase in the computational power readily available since the first numerical treatments of electrochemical problems in the early 1960s. This development has been accompanied by the development of powerful, widely available, commercial software modelling tools. Despite this, approximate analytical treatments remain extremely useful in the modelling of coupled diffusion/reaction problems in electrochemistry because of the insights they provide into the different possible behaviours of the system. In this paper we discuss the modelling of amperometric enzyme electrodes, taking as our exemplar redox hydrogel-based enzyme electrodes in which the enzyme is immobilized in a redox active polymer which wires the enzyme to the electrode. In this system the measured current is related to many different experimental variables including substrate concentration and diffusion coefficient, reaction rate constants, and film properties and thickness. The interplay of these factors is described and the role of Case diagrams in understanding coupled diffusion/reaction problems of this type is discussed.</p
sj-docx-1-opp-10.1177_10781552231218999 - Supplemental material for Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review
No full textSupplemental material, sj-docx-1-opp-10.1177_10781552231218999 for Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review by Wardah Javed Khan, Mubeen Ali, Sana Hashim, Huma Nawaz, Syeda Nafeesa Hashim, Danish Safi, and Arslan Inayat in Journal of Oncology Pharmacy Practice</p
sj-docx-2-opp-10.1177_10781552231218999 - Supplemental material for Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review
No full textSupplemental material, sj-docx-2-opp-10.1177_10781552231218999 for Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review by Wardah Javed Khan, Mubeen Ali, Sana Hashim, Huma Nawaz, Syeda Nafeesa Hashim, Danish Safi, and Arslan Inayat in Journal of Oncology Pharmacy Practice</p
Samarkand Under the Leadership of Vali Muhammad Khan
No full textIn this article, the processes of the political life of the Ashtarkhanid dynasty and the importance of the Samarkand region in it, the Battle of Samarkand, the seizure of power by Imam Quli Khan with the help of Khoja Hashim Dahbedi, a descendant of Samarkand Sheikh Mahdumi Azam, the execution of the fathers Shahbek Kokaltash and Nazir Kokaltash by Imam Quli Khan and Nadr Muhammad, are the events of Samarkand. it is mentioned that it was carried out in the territory
Samarkand Under the Leadership of Vali Muhammad Khan
No full textIn this article, the processes of the political life of the Ashtarkhanid dynasty and the importance of the Samarkand region in it, the Battle of Samarkand, the seizure of power by Imam Quli Khan with the help of Khoja Hashim Dahbedi, a descendant of Samarkand Sheikh Mahdumi Azam, the execution of the fathers Shahbek Kokaltash and Nazir Kokaltash by Imam Quli Khan and Nadr Muhammad, are the events of Samarkand. it is mentioned that it was carried out in the territory
Emirs of Uzbek Khan and Janibek Khan
No full textThis article explores the question about the origin of the Golden Horde emirs’ dynasties during the reign of Uzbek and Janibek khan. Based on numerous Venetian, Arabic, Turkish, Persian primary sources the author provides his own version of origin and genealogical relationships of various emirs. Based on a list of emirs of Janibek khan from «Daftar-i Chingiz-name», the author traces the origins of Mogul-buga to Kipchak tribe and the origins of Kutlu buga to Naiman tribe. Author argues that during the reign of Uzbek khan, the Kungirat and Kiyat were the most influential clans. The Kipchak and Nayman were the most influential clans during the reign of Janibek khan. The author considers three-level hierarchy of emirs. The first level includes the emirs – clan rulers in every district (ulus). There were 4 tribes in each ulus. The second level includes the emirs who were the rulers of ulus. After the administrative reform of Uzbek khan, they replaced the Jochids in the political system of the Golden Horde. If formerly the governance of ulus was inherited by one of the Jochids, then during the reign of Uzbek khan emirs were appointed directly from the center. The third level includes four Karachi Beys who were advisers of the khan. The author also examines the origin of Nanguday from Kungirat clan. The author puts forward his own version of a genealogy of Nanguday. Additionally, this article contains the author’s assumptions about biography of Isatay Kiyat and Isa Uysun. According to these assumptions, Isatay Kiyat can be identified with well-known Gourgen Isa. And Isa Uysun, in turn, can be identified with the brother of Tuluk Timur, who was a governor of the Crimea in the era of Uzbek khan
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