1,720,962 research outputs found
Mesenchymal stem cell therapy and cardiac function: clinical experience in patients with myocardial infarction?
No full textMesenchymal stem cell therapy and cardiac function: clinical experience in patients with myocardial infarction?
No full textAdult mouse spermatogonial stem cells differentiate into cardiovascular lineages and generate functional cardiomyocytes
No full textAdult mouse spermatogonial stem cells differentiate into cardiovascular lineages and generate functional cardiomyocytes
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cardiovascular MRI–derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis
No full textCardiac MRI–derived imaging markers demonstrated significant prognostic value in individuals with severe aortic stenosis, with right atrial strain independently predicting cardiovascular mortality and enabling identification of additional high-risk subgroups.Purpose To assess the prognostic implications of cardiac MRI–derived imaging markers in individuals with severe aortic stenosis (AS). Materials and Methods This prospective study (German Clinical Trials Register, DRKS00024479) enrolled individuals with severe AS who underwent cardiac MRI before transcatheter aortic valve replacement (TAVR) from January 2017 to March 2022. Image analyses included myocardial volumes, cardiac MRI feature tracking–derived left atrial (LA) and right atrial (RA) as well as left ventricular (LV) and right ventricular (RV) strain, myocardial T1 mapping, and late gadolinium enhancement analyses. Cardiovascular (CV) mortality was defined as primary clinical end point. Cox proportional hazards models were used to determine the association between cardiac MRI–derived parameters and CV mortality. Results The final analysis included 145 participants (median age, 80 years [IQR, 75–83 years]; 91 male). Participants who experienced CV death during follow-up had significantly enlarged RV end-diastolic volumes (median, 82.9 [IQR, 70.8–96.0] mL/m 2 vs 62.8 [54.7–76.0] mL/m 2 ; P < .001) and impaired strain values of all cardiac chambers compared with those who survived (LV global longitudinal strain [GLS], −18.1% [−13.1% to −20.4%] vs −22.5% [−16.1% to −27.3%], P = .02; RV GLS, −22.9% [−18.6% to −25.4%] vs −27.9% [−22.9% to −32.0%], P = .002; LA atrial reservoir strain [Es], 9.5% [7.2%–15.4%] vs 14.3% [9.0%–18.1%], P = .04; RA Es, 12.4% [6.8%–14.4%] vs 16.2% [11.2%–22.1%], P < .001). RA reservoir strain independently helped predict CV mortality after adjustment for other cardiac MRI markers and clinical parameters of heart failure (hazard ratio, 0.82 [95% CI: 0.71, 0.95]; P = .008). Within the subgroup of participants with high extracellular volume values, RA strain further identified participants with AS at high risk for CV mortality ( P = .001 on log-rank testing). Conclusion In individuals with AS undergoing TAVR, several cardiac MRI parameters were significantly associated with CV mortality. RA strain was an independent predictor of CV mortality and may provide more optimized patient management. Keywords: Cardiac MRI, Aortic Stenosis, TAVR, Risk Assessment, Strain Analyses German Clinical Trials Register no. DRKS00024479 Supplemental material is available for this article. © RSNA, 2025Cardiac MRI–derived imaging markers demonstrated significant prognostic value in individuals with severe aortic stenosis, with right atrial strain independently predicting cardiovascular mortality and enabling identification of additional high-risk subgroups.Purpose To assess the prognostic implications of cardiac MRI–derived imaging markers in individuals with severe aortic stenosis (AS). Materials and Methods This prospective study (German Clinical Trials Register, DRKS00024479) enrolled individuals with severe AS who underwent cardiac MRI before transcatheter aortic valve replacement (TAVR) from January 2017 to March 2022. Image analyses included myocardial volumes, cardiac MRI feature tracking–derived left atrial (LA) and right atrial (RA) as well as left ventricular (LV) and right ventricular (RV) strain, myocardial T1 mapping, and late gadolinium enhancement analyses. Cardiovascular (CV) mortality was defined as primary clinical end point. Cox proportional hazards models were used to determine the association between cardiac MRI–derived parameters and CV mortality. Results The final analysis included 145 participants (median age, 80 years [IQR, 75–83 years]; 91 male). Participants who experienced CV death during follow-up had significantly enlarged RV end-diastolic volumes (median, 82.9 [IQR, 70.8–96.0] mL/m 2 vs 62.8 [54.7–76.0] mL/m 2 ; P < .001) and impaired strain values of all cardiac chambers compared with those who survived (LV global longitudinal strain [GLS], −18.1% [−13.1% to −20.4%] vs −22.5% [−16.1% to −27.3%], P = .02; RV GLS, −22.9% [−18.6% to −25.4%] vs −27.9% [−22.9% to −32.0%], P = .002; LA atrial reservoir strain [Es], 9.5% [7.2%–15.4%] vs 14.3% [9.0%–18.1%], P = .04; RA Es, 12.4% [6.8%–14.4%] vs 16.2% [11.2%–22.1%], P < .001). RA reservoir strain independently helped predict CV mortality after adjustment for other cardiac MRI markers and clinical parameters of heart failure (hazard ratio, 0.82 [95% CI: 0.71, 0.95]; P = .008). Within the subgroup of participants with high extracellular volume values, RA strain further identified participants with AS at high risk for CV mortality ( P = .001 on log-rank testing). Conclusion In individuals with AS undergoing TAVR, several cardiac MRI parameters were significantly associated with CV mortality. RA strain was an independent predictor of CV mortality and may provide more optimized patient management. Keywords: Cardiac MRI, Aortic Stenosis, TAVR, Risk Assessment, Strain Analyses German Clinical Trials Register no. DRKS00024479 Supplemental material is available for this article. © RSNA, 202
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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