38 research outputs found
Biomaterials for Cartilage Regeneration
No full textOrthopedicsSurgerySCI(E)0EDITORIAL MATERIAL10674-6762
Mujeeb Khan. “The Two Ibn Sīnās: Negotiating Literature”
No full textThe author compares Ibn Sīnā’s medical poem as an expression of different perspectives on medical literature held by Ibn Sīnā. He is main interest is to discuss textual agency in the conceptualization of medical literature. The author argues that the organization of the poem, the use of examples, the inclusion of surgery, as well as the exclusion of various themes speak against previous interpretations as a simple, didactic tool for memorizing medical information. Instead of calling it didact..
Dispensing practices for psychotropic medications amongst pharmacists in Karachi, Pakistan
No full textBACKGROUND & OBJECTIVE: Uninformed use of medications can be dangerous especially those medications that require some level of monitoring to ensure safety and tolerability and prevent misuse, such as benzodiazepines and other psychotropic medications. In most developed countries, medications (except over-the-counter medications) are not dispensed without a physician's script. This may not be true for developing countries, like Pakistan, where nearly all medications are dispensed without a script. However, the extent and nature of script-less dispensing has never been studied. This study was designed to investigate the extent and prevalence of dispensing psychotropic medications without physicians' prescriptions, and the pharmacy practices, including the staff qualifications, to not only dispense but also recommend psychotropic medications, in Karachi, Pakistan. METHOD: A Cross-sectional study was conducted in Karachi over three months (September 2021 to November 2021) with 200 pharmacists in various pharmacies, using a structured questionnaire in a convenient study sample. Pharmacists from registered pharmacies were included in the study. Statistical analysis was done using the Chi-Square test of association. RESULTS: Out of 200 pharmacists working at various locations, 89.0% did not required prescriptions to dispense medications, with benzodiazepines being the most frequently dispensed medication. Surprisingly, only 9.0% had a bachelor's in pharmacy and were qualified enough to legally dispense medications. 76.0% admitted to recommending medications to the patients. Since many of the pharmacists were not qualified enough to dispense medications, 78.5% mentioned that they did not had awareness regarding the abuse potential of psychotropic medications. CONCLUSION: Dispensing of psychotropic medications without prescriptions and recommending such medications has been a significant issue in the past. Our study reveals this practice to be prevalent in this part of the world, posing a serious threat to the patients. Steps should be taken by the government to ensure proper dispensing of these medications having an abuse potential to prevent harm
Diagnosis and Management of Major Depressive Disorder in Primary Care Clinics in Karachi, Pakistan
No full textHeavy quark potential in a static and strong homogeneous magnetic field
No full textAbstract We have investigated the properties of quarkonia in a thermal QCD medium in the background of strong magnetic field. For that purpose, we employ the Schwinger proper-time quark propagator in the lowest Landau level to calculate the one-loop gluon self-energy, which in the sequel gives the effective gluon propagator. As an artifact of strong magnetic field approximation ( e B > > T 2 and e B > > m 2 ), the Debye mass for massless flavors is found to depend only on the magnetic field which is the dominant scale in comparison to the scales prevalent in the thermal medium. However, for physical quark masses, it depends on both magnetic field and temperature in a low temperature and high magnetic field but the temperature dependence is very meager and becomes independent of the temperature beyond a certain temperature and magnetic field. With the above mentioned ingredients, the potential between heavy quark (Q) and anti-quark ( Q ¯ ) is obtained in a hot QCD medium in the presence of a strong magnetic field by correcting both short- and long-range components of the potential in the real-time formalism. It is found that the long-range part of the quarkonium potential is affected much more by magnetic field as compared to the short-range part. This observation facilitates us to estimate the magnetic field beyond which the potential will be too weak to bind Q Q ¯ together. For example, the J / ψ is dissociated at e B ∼ 10 m π 2 and Υ is dissociated at e B ∼ 100 m π 2 whereas its excited states, ψ ′ and Υ ′ are dissociated at smaller magnetic field e B = m π 2 , 13 m π 2 , respectively
On the Importance of Pooling Layer Tuning for Profiling Side-Channel Analysis
No full textIn recent years, the advent of deep neural networks opened new perspectives for security evaluations with side-channel analysis. Profiling attacks now benefit from capabilities offered by convolutional neural networks, such as dimensionality reduction and the inherent ability to reduce the trace desynchronization effects. These neural networks contain at least three types of layers: convolutional, pooling, and dense layers. Although the definition of pooling layers causes a large impact on neural network performance, a study on pooling hyperparameters effect on side-channel analysis is still not provided in the academic community. This paper provides extensive experimental results to demonstrate how pooling layer types and pooling stride and size affect the profiling attack performance with convolutional neural networks. Additionally, we demonstrate that pooling hyperparameters can be larger than usually used in related works and still keep good performance for profiling attacks on specific datasets.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Process, methods and tools for ship damage stability and flooding risk assessment
No full textDevelopment of damage stability as a scientific subject, specifically in damage ship hydrodynamics and, generally, flooding risk assessment, has evolved primarily by inquisitive academics with support by people with vision and passion towards maritime safety enhancement from industry and Government, the latter in the wake of serious accidents. Notwithstanding this, the subject has seen remarkable development in a short period of time in terms of understanding process, and developing methods and tools for practical implementation of such developments. The stage has now been reached where large-scale EC and industry-funded projects are bringing all requisite knowledge and experience together towards implementation by end users with the view to institutionalizing such developments. The paper critically traces and presents key developments starting from basic concepts to a complete framework for performing numerical simulations of ship survivability in operational conditions in the seaway, leading to flooding risk assessment with application potential for new and existing ships with focus on the design phase but with operation potential in ship operation, the latter involving emergencies
Peptide Bionanomaterials Global Market: The Future of Emerging Industry
No full textOver the years, the rising popularity of peptides has led to a paradigm shift in the focus of biotechnology and pharmaceutical industry from traditional molecular-based interventions to the development of multifaceted nanomaterial-based interventions. The ‘bench-to-bedside’ approach has enabled researchers to work with a variety of peptide-based bionanomaterials for applications in tissue engineering, regenerative medicine, drug delivery, biosensing and 3D printing, paving the way for clinical translation. Owing to the very nature of peptide molec-ular building blocks that form the basis of self-assembled biomaterials, the final materials exhibit extraordinary properties, such as biocompatibility, flexibility in design, reproducibility and stability, which help expedite their translation into different application domains within biomedicine. In this chapter, we highlight the clinical need for translation of peptide nanomaterials, outline current priority appli-cation areas and discuss how these are currently bridging gaps between academic and industrial research to support product development, scale up and adoption of technology. The chapter also outlines the substantial growth in global market size of peptide-based biomaterial products. Many examples of peptide nanomaterials include hydrogels as scaffolds and wound dressing materials; 3D printed nanostructures; and nanotubes as drug delivery vehicles and components for recon-struction of soft tissues and 3D cell culture. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Quarkonia dissociation at finite magnetic field in the presence of momentum anisotropy
No full textIn this study, we investigate the potential of heavy quarkonia within a magnetized hot QGP medium having finite momentum anisotropy. The phenomenon of inverse magnetic catalysis is introduced into the system, influencing the magnetic field-modified Debye mass and thereby altering the effective quark masses. Concurrently, the impact of momentum anisotropy in the medium is considered that influence the particle distribution in the medium. The thermal decay width and dissociation temperature of quarkonium states, specifically the 1S and 2S states of charmonium and bottomonium, are computed. Our results reveal that both momentum anisotropy and the inverse magnetic catalysis effects play a significant role in modifying the thermal decay width and dissociation temperature of these heavy quarkonia states
Seedling Resistance to Stagonospora nodorum Blotch in Wheat Genotypes
No full textIn two independent experiments set up in the greenhouse the seedling resistance to Stagonospora nodorum blotch was investigated in 92 varieties, breeding lines and genotypes with a known genetic background. The greatest area under the disease progress curve calculated from lesion type was 37.06, while in the case of the most resistant genotype this value was 0.38. Many of the lines and varieties bred in Martonvásár proved to have excellent resistance in terms of both percentage of infected leaf area and lesion type. Observations indicate that, depending on the aim of the experiment, the efficient selection of breeding lines is possible in the seedling stage either on the basis of the area under the disease progress curve calculated for lesion types, or on the basis of lesion types scored 7, 11 or 14 days after inoculation
