2,703 research outputs found
Recommended from our members
GJ 3929: High-precision Photometric and Doppler Characterization of an Exo-Venus and Its Hot, Mini-Neptune-mass Companion
No full textWe detail the follow-up and characterization of a transiting exo-Venus identified by TESS, GJ 3929b (TOI-2013b), and its nontransiting companion planet, GJ 3929c (TOI-2013c). GJ 3929b is an Earth-sized exoplanet in its star’s Venus zone (P b = 2.616272 ± 0.000005 days; Sb = 17.3 − 0.7 + 0.8 S ⊕) orbiting a nearby M dwarf. GJ 3929c is most likely a nontransiting sub-Neptune. Using the new, ultraprecise NEID spectrometer on the WIYN 3.5 m Telescope at Kitt Peak National Observatory, we are able to modify the mass constraints of planet b reported in previous works and consequently improve the significance of the mass measurement to almost 4σ confidence (M b = 1.75 ± 0.45 M ⊕). We further adjust the orbital period of planet c from its alias at 14.30 ± 0.03 days to the likely true period of 15.04 ± 0.03 days, and we adjust its minimum mass to m sin i = 5.71 ± 0.92 M ⊕. Using the diffuser-assisted ARCTIC imager on the ARC 3.5 m telescope at Apache Point Observatory, in addition to publicly available TESS and LCOGT photometry, we are able to constrain the radius of planet b to R p = 1.09 ± 0.04 R ⊕. GJ 3929b is a top candidate for transmission spectroscopy in its size regime (TSM = 14 ± 4), and future atmospheric studies of GJ 3929b stand to shed light on the nature of small planets orbiting M dwarfs. © 2022. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Chlamydia psittaci infection in canaries heavily infested by Dermanyssus gallinae
No full textDermanyssus gallinae is a haematophagous ectoparasite responsible for anemia, weight loss, dermatitis and a decrease in egg production. Dermanyssus gallinae may play a role in the modulation of the host immune system, maybe predisposing the host to some bacterial infections such as chlamydiosis. This is an important zoonosis. Humans are exposed to Chlamydia psittaci through inhalation of the agent dispersed from the infected birds. In this study, a syndrome observed in an aviary of canaries was investigated. A heavy infestation by D. gallinae was reported. Simultaneously, a C. psittaci infection was molecularly confirmed in the canaries. Combined therapy was applied successfully. The association of C. psittaci with the examined mites has been confirmed. Therefore, we think that D. gallinae have played a role in the spreading of C. psittaci infection among the canaries. Moreover, D. gallinae could have played an important role predisposing the canaries to the development of chlamydiosis, by inducing anemia and debilitation. The control of mites in the aviaries may represent a crucial step for the prevention of important infection such as chlamydiosis in birds and humans
The Optimization of the Performance Management for Operators in GJ Company Xiamen
No full text本文以绩效管理的基本理论和GJ厦门厂的实际情况为基础，分析了GJ厦门厂一线作业员绩效管理的问题点，并结合公司目前的实际情况提出一线作业员的绩效管理改善方案。该方案以平衡计分卡的绩效管理体系为逻辑，将公司的战略目标分解到制造处，再分解至一线作业员，让作业员的绩效也能从财务面、客户面、内部运营面、学习成长面四个维度上对公司的战略发展起到支撑作用，以促进组织战略目标的实现。 在绩效管理改进方案中，作者特别强调沟通在绩效管理过程中的重要作用，它贯穿了绩效管理的整个过程。沟通有助于促进员工个人绩效的提升和员工个人的成长，从而提升组织的整体效益。 根据GJ厦门厂的实际情况，将一线作业员的绩效考核结...In this paper, operators’ performance management problems in GJ Company are analyzed based on the basic theory of performance management and the real situation of the company. The author propose to break down the company’s strategic targets to lower levels with balanced scorecard system by four levels of financial, customer, internal operation, learning and developing. So that operators’ performa...学位：管理学硕士院系专业：管理学院_工商管理硕士(工商管理硕士)学号：1792012115103
Exergy comparison of lunar propellant manufacturing and insertion into LEO using a fully reusable refueling rocket
No full textQuantifying the exergy requirement of propellant insertion into LEO can lead to insight into the feasibility of a lunar propellant-generating architecture. Spacecraft leaving from Earth can greatly reduce their lift-off mass if in-space refueling would possible. Exergy analyses quantify the available energy of a system and show where a reduction in usable energy occurs. Insight into the exergy destruction and input provides a key parameter into the scaling and design of processes and corresponding power systems. The present study aims to define an exergy environment in the lunar PSRs and then to analyze the exergy destruction related to the production of oxygen, ALICE, and hydrolox, in terms of both manufacturing and transportation using a two-stage fully reusable rocket. Extraction processes for ALICE and hydrolox were selected and analyzed w.r.t. the lunar environment to get an understanding of the exergy input. The behavior and exergy requirements of an LEO propellant depot was described. Two fully reusable two-stage rockets using ALICE and hydrolox were designed and compared based on their payload-to-propellant ratio for the oxygen, ALICE, and hydrolox payloads. The study found that the exergetic cost for the insertion of oxygen, hydrolox, and ALICE in LEO were 1.32 GJ/kg , 1.64 GJ/kg, and GJ/kg and 23.3 GJ/kg, 23.4 GJ/kg and 26.9 GJ/kg for the hydrolox and ALICE rocket, respectively.Aerospace Engineerin
Recommended from our members
Double Trouble: Two Transits of the Super-Earth GJ 1132 b Observed with JWST NIRSpec G395H
No full textThe search for rocky planet atmospheres with JWST has focused on planets transiting M dwarfs. Such planets have favorable planet-to-star size ratios, enhancing the amplitude of atmospheric features. Since the expected signal strength of atmospheric features is similar to the single-transit performance of JWST, multiple observations are required to confirm any detection. Here, we present two transit observations of the rocky planet GJ 1132 b with JWST NIRSpec G395H, covering 2.8-5.2 μm. Previous Hubble Space Telescope WFC3 observations of GJ 1132 b were inconclusive, with evidence reported for either an atmosphere or a featureless spectrum based on analyses of the same data set. Our JWST data exhibit substantial differences between the two visits. One transit is consistent with either an H2O-dominated atmosphere containing ∼1% CH4 and trace N2O ( χ ν 2 = 1.13 ) or stellar contamination from unocculted starspots ( χ ν 2 = 1.36 ). However, the second transit is consistent with a featureless spectrum. Neither visit is consistent with a previous report of HCN. Atmospheric variability is unlikely to explain the scale of the observed differences between the visits. Similarly, our out-of-transit stellar spectra show no evidence of changing stellar inhomogeneity between the two visits—observed 8 days apart, only 6.5% of the stellar rotation rate. We further find no evidence of differing instrumental systematic effects between visits. The most plausible explanation is an unlucky random noise draw leading to two significantly discrepant transmission spectra. Our results highlight the importance of multivisit repeatability with JWST prior to claiming atmospheric detections for these small, enigmatic planets. © 2023. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Ves v 5 can establish the diagnosis in patients without detectable specific IgE to wasp venom and a possible north-south difference in Api m 1 sensitization in Europe.
No full textauthor reply 818-9;
Comment on
High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy. [J Allergy Clin Immunol. 2012
Energy Analysis In The Assessment Of The U.K. Wave Energy Programme, 1978
No full text1.1 In a long term situation of rising energy prices convention al economic appraisal of energy technologies has a number of shortcomings. It is not possible to determine the inflationary effects of energy price rises on costs and also it is a very uncertain guide in R & D planning. By using energy analysis the energy element in costs and the inflationary effects of price rises can be determined directly . Also the net energy requirement is an index of merit which is available during the R & D phase and can be related theoretically to the economics of a technology. It provides a good indicator, during R & D, of economic potential. 1.2 The calculations reported here for wave energy systems are based mainly on information contained in RPT 1978 draft report and hence relate to the reference designs as then conceived. 1.3 The modal net energy requirements (energy input/energy output) for the 1978 Reference Designs on a primary energy basis are as follows National Engineering Laboratories (NEL) 2.79 GJ₍ₜ₎/GJ₍ₑ₎ Wavepowe r Limited ( WPL) 1.45 GJ₍ₜ₎/GJ₍ₑ₎ Hydraulics Research S t ation (HRS) 3.27 GJ₍ₜ₎/GJ₍ₑ₎ Sea Energy Associates (SEA) 2.89 GJ₍ₜ₎/GJ₍ₑ₎ French Flexible Bag (FFB) 0.46 GJ₍ₜ₎/GJ₍ₑ₎ 1.4 On the basis of this information only the FFB satisfies the basic criteria of energetic viability. This criteria is that the net energy requirement of a wave energy system should be less than one. 1.5 While it is not possible as yet to establish the precise relationships between energy requirement and economic viability, clearly the 'energy returns' of the FFB are so low as to make it doubtful that this device would ever be economically viable in this form. 1.6 It is possible to model simply the relationship between energy requirements and costs. This indicates that a technology with a high energy requirement will suffer rapid cost inflation as energy prices rise. Depending on estimates of the value of output electricity (compared with the value of firm electricity) it seems that energy prices will have to rise 13 times before the FFB becomes economically viable. This is far beyond the limits of current medium term and even long-term planning horizons . l.7 It is difficult to imagine any realistic economic circumstances which may develop in the medium and long term which would make wave energy, in this form, economically viable. 1.8 To radically alter this assessment will r e quire a reduction in net energy requirement by factors ranging from 2.3 (FFB) to 16 (HRS). These improvements can only be achieved by substantial reductions in masses of structural and mooring materials per unit output together with improvements in the average load factor of all installed machinery. 1.9 Energy analysis raises serious questions about the wave energy programme. These must be answered convincingly before a rational case for committing major funds to the further development of these designs can be made. In particular the current emphasis on design for production would seem to be premature when basic problems of device size remain unresolved. 1.10 Further work is required constructing models of the net energy requirement of all devices in the prograrmme in terms of major system parameters (structural size, peak/average power ratings etc . ). Also energy analysis of new concepts and generic studies of wave energy devices is required. In this way established devices and new concept s will be analysed in a systematic way and it may be possible to identify directions of development which will offer the possibility of wave energy devices with low net energy requirements and with the ultimate potential to be economically viable
Diagnosing Intermittent Faults
No full textIn this working report we outline how to determine the intermittency parameters gj from the activity matrix A (context: DX’08 paper Abreu, Zoeteweij, Van Gemund). We start with the single fault (SF) case and show that averaging over the error vector e is the exact way. We also show that in this way the probability of obtaining exactly this e vector in A is optimal. This is the key insight that allows us to determine g in the general multiple-fault (MF) case. We formulate the gj problem as a (probability) maximization problem, which we solve using a simple gradient ascent technique.Software Computer TechnologyElectrical Engineering, Mathematics and Computer Scienc
Testing contributor & translator roles - harvest
No full textGJ author, edited to add dc.contributor and dc.contributor.translator; cc-by-nc-n
TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21(Cip1) or Rb status
No full textMelville Trust for the Care and Cure of Cancer to SP and SS.Background: TGF beta has pleiotropic effects that range from regulation of proliferation and apoptosis to morphological changes and epithelial-mesenchymal transition (EMT). Some evidence suggests that these effects may be interconnected. We have recently reported that P53, P21(Cip1) and pRB, three critical regulators of the G1/S transition are variably involved in TGF beta-induced cell cycle arrest in hepatocytes. As these proteins are also involved in the regulation of apoptosis in many circumstances, we investigated their contribution to other relevant TGF beta-induced effects, namely apoptosis and EMT, and examined how the various processes were interrelated. Methods: Primary mouse hepatocytes deficient in p53, p21 and/or Rb, singly or in combination were treated with TGF beta for 24 to 96 hours. Apoptosis was quantified according to morphology and by immunostaining for cleavedcapsase 3. Epithelial and mesenchymal marker expression was studied using immunocytochemistry and real time PCR. Results: We found that TGF beta similarly induced morphological changes regardless of genotype and independently of proliferation index or sensitivity to inhibition of proliferation by TGF beta. Morphological changes were accompanied by decrease in E-cadherin and increased Snail expression but the mesenchymal markers (N-cadherin, SMA alpha and Vimentin) studied remained unchanged. TGF beta induced high levels of apoptosis in p53-/-, Rb-/-, p21(cip1)-/- and control hepatocytes although with slight differences in kinetics. This was unrelated to proliferation or changes in morphology and loss of cell-cell adhesion. However, hepatocytes deficient in both p53 and p21(cip1)were less sensitive to TGF beta-induced apoptosis. Conclusion: Although p53, p21(Cip1) and pRb are well known regulators of both proliferation and apoptosis in response to a multitude of stresses, we conclude that they are critical for TGF beta-driven inhibition of hepatocytes proliferation, but only slightly modulate TGF beta-induced apoptosis. This effect may depend on other parameters such as proliferation and the presence of other regulatory proteins as suggested by the consequences of p53, p21(Cip1) double deficiency. Similarly, p53, p21(Cip1) and pRB deficiency had no effect on the morphological changes and loss of cell adhesion which is thought to be critical for metastasis. This indicates that possible association of these genes with metastasis potential would be unlikely to involve TGF beta-induced EMT.Peer reviewe
- …
