143 research outputs found
Algorithmic Analysis Techniques for Molecular Imaging
No full textThis study addresses image processing techniques for two medical imaging
modalities: Positron Emission Tomography (PET) and Magnetic Resonance
Imaging (MRI), which can be used in studies of human body functions and
anatomy in a non-invasive manner.
In PET, the so-called Partial Volume Effect (PVE) is caused by low
spatial resolution of the modality. The efficiency of a set of PVE-correction
methods is evaluated in the present study. These methods use information
about tissue borders which have been acquired with the MRI technique. As
another technique, a novel method is proposed for MRI brain image segmen-
tation. A standard way of brain MRI is to use spatial prior information
in image segmentation. While this works for adults and healthy neonates,
the large variations in premature infants preclude its direct application.
The proposed technique can be applied to both healthy and non-healthy
premature infant brain MR images. Diffusion Weighted Imaging (DWI) is
a MRI-based technique that can be used to create images for measuring
physiological properties of cells on the structural level. We optimise the
scanning parameters of DWI so that the required acquisition time can be
reduced while still maintaining good image quality.
In the present work, PVE correction methods, and physiological DWI
models are evaluated in terms of repeatabilityof the results. This gives in-
formation on the reliability of the measures given by the methods. The
evaluations are done using physical phantom objects, correlation measure-
ments against expert segmentations, computer simulations with realistic
noise modelling, and with repeated measurements conducted on real pa-
tients. In PET, the applicability and selection of a suitable partial volume
correction method was found to depend on the target application. For MRI,
the data-driven segmentation offers an alternative when using spatial prior is
not feasible. For DWI, the distribution of b-values turns out to be a central
factor affecting the time-quality ratio of the DWI acquisition. An optimal
b-value distribution was determined. This helps to shorten the imaging time
without hampering the diagnostic accuracy.Siirretty Doriastaei tietoa saavutettavuudest
Infants' sex affects neural responses to affective touch in early infancy
No full textSocial touch is closely related to the establishment and maintenance of social bonds in humans, and the sensory brain circuit for gentle brushing is already active soon after birth. Brain development is known to be sexually dimorphic, but the potential effect of sex on brain activation to gentle touch remains unknown. Here, we examined brain activation to gentle skin stroking, a tactile stimulation that resembles affective or social touch, in term-born neonates. Eighteen infants aged 11–36 days, recruited from the FinnBrain Birth Cohort Study, were included in the study. During natural sleep, soft brush strokes were applied to the skin of the right leg during functional magnetic resonance imaging (fMRI) at 3 cm/s velocity. We examined potential differ- ences in brain activation between males (n = 10) and females (n = 8) and found that females had larger blood oxygenation level dependent (BOLD) responses (brushing vs. rest) in bilateral orbitofrontal cortex (OFC), right ventral striatum and bilateral inferior striatum, pons, and cerebellum compared to males. Moreover, the psychophysiologi- cal interactions (PPI) analysis, setting the left and right OFC as seed regions, revealed significant differences between males and females. Females exhibited stronger PPI connectivity between the left OFC and posterior cingulate or cuneus. Our work sug- gests that social touch neural responses are different in male and female neonates, which may have major ramifications for later brain, cognitive, and social development. Finally, many of the sexually dimorphic brain responses were subcortical, not captured by surface-based neuroimaging, indicating that fMRI will be a relevant technique for future studies
Signal to noise and b-value analysis for optimal intra-voxel incoherent motion imaging in the brain
No full textISSN:1932-620
Batch processing with Matlab and in-house software
No full text<p>Oral presentation in Turku XIII PET symposium</p
Sex difference in brain CB1 receptor availability in man
No full textThe endocannabinoid system (ECS) has a widespread neuromodulatory function in the central nervous system and is involved in important aspects of brain function including brain development, cortical rhythms, plasticity, reward, and stress sensitivity. Many of these effects are mediated via the cannabinoid CB1 receptor (CB1R) subtype. Animal studies convincingly show an interaction between the ECS and sex hormones, as well as a sex difference of higher brain CB1R in males. Human in vivo studies of sex difference have yielded discrepant findings. Gender differences in CB1R availability were investigated in vivo in 11 male and 11 female healthy volunteers using a specific CB1R tracer [18F]FMPEP-d2 and positron emission tomography (PET). Regional [18F]FMPEP-d2 distribution volume was used as a proxy for CB1R availability. In addition, we explored whether CB1R availability is linked to neuropsychological functioning. Relative to females, CB1R availability was on average 41% higher in males (p = 0.002) with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices (p = 0.001). Inter-subject variability in CB1R availability was similar in both groups. Voxel-based analyses revealed an inverse association between CB1R availability and visuospatial working memory task performance in both groups (
Evaluation of partial volume effect correction methods for brain positron emission tomography: Quantification and reproducibility
No full textQuantitative accuracy of positron emission tomography (PET) is decreased by the partial volume effect (PVE). The PVE correction (PVC) methods proposed by Alfano et al., Rousset et al., Müller-Gδrtner et al. and Meltzer et al. were evaluated in the present study to obtain guidelines for selecting among them. For accuracy evaluation, the Hoffman brain phantom was scanned with three PETs of differing spatial resolution in order to measure the effect of PVC on radioactivity distribution. Test-retest data consisting of duplicate dynamic emission recordings of the dopamine D2-receptor ligand [ 11 C] raclopride obtained in eight healthy control subjects were used to test the correction effect in different regions of interest. The PVC method proposed by Alfano et al. gave the best quantification accuracy in the brain gray matter region. When the effect of PVC on reliability was tested with human data, the method of Meltzer et al. proved to be the most reliable. The method by Alfano et al. may be better for group comparison studies and the method by Meltzer et al. for intra-subject drug-effect studies
How to read biparametric MRI in men with a clinical suspicious of prostate cancer: Pictorial review for beginners with public access to imaging, clinical and histopathological database
No full text: Prostate Magnetic Resonance Imaging (MRI) is increasingly being used in men with a clinical suspicion of prostate cancer (PCa). Performing prostate MRI without the use of an intravenous contrast (IV) agent in men with a clinical suspicion of PCa can lead to reduced MRI scan time. Enabling a large array of different medical providers (from mid-level to specialized radiologists) to evaluate and potentially report prostate MRI in men with a clinical suspicion of PCa with a high accuracy could be one way to enable wide adoption of prostate MRI in men with a clinical suspicion of PCa. The aim of this pictorial review is to provide an insight into acquisition, quality control and reporting of prostate MRI performed without IV contrast agent in men with a clinical suspicion of PCa, aimed specifically at radiologists starting reporting prostate MRI, urologists, urology/radiology residents and mid-level medical providers without experience in reporting prostate MRI. Free public access (http://petiv.utu.fi/improd/and http://petiv.utu.fi/multiimprod/) to complete datasets of 161 and 338 men is provided. The imaging datasets are accompanied by clinical, laboratory and histopathological findings. Several topics are simplified in order to provide a solid base for the development of skills needed for an unsupervised review and potential reporting of prostate MRI in men with a clinical suspicion of PCa. The current review represents the first step towards enabling a large array of different medical providers to review and report accurately prostate MRI performed without IV contrast agent in men with a clinical suspicion of PCa
Standard deviations (SD) of IVIM parameter maps <i>D*</i> and <i>f</i> in brain grey and white matter over four healthy volunteers, using optimized b value distributions for optimized b value settings from analysis of direct SD measurements, and CRLB using noise estimates, for 3, 6, and 12 minutes scans.
No full textStandard deviations (SD) of IVIM parameter maps D* and f in brain grey and white matter over four healthy volunteers, using optimized b value distributions for optimized b value settings from analysis of direct SD measurements, and CRLB using noise estimates, for 3, 6, and 12 minutes scans.</p
Suggested optimized b value sets for brain IVIM.
No full textSuggested optimized b value sets for brain IVIM.</p
Fig 2 -
No full textCoefficient of variation (SD/mean) as a function of b values and number of averages, in the gray matter (left) and the white matter (right) for four healthy volunteers in DWI trace images in b-values ranging from 0 to 900 s/mm2and number of repetitions for signal averaging in 1 to 20. Gray matter variation begins to drop after b = 170 s/mm2 and with 4 repetitions, while white matter variation is generally less and with negligible differences between b-values and repetitions in range 9% to 10.5%, and lowest points around b = 80–140 s/mm2 and when using 4 to 13 averages.</p
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