4,206 research outputs found
Colección: Perfil #3
No full textThis board-book version of LM turns out to be quite creative. Ratoncete comes from school every afternoon and goes through the forest looking for adventures. He apparently blasts a horn into the ear of the sleeping lion. Don Leon wants to spank him as a result, but Ratoncete offers an apology, not an offer of help. Later, he happens upon the lion in his trap of ropes. 8 pages, counting both covers. 6½" x 9".Language note: SpanishNo Autho
Interference Improves Myopathic Phenotypes in Mice Over-expressing FSHD Region Gene 1 (FRG1).
No full textMuscular dystrophies, and other diseases of muscle, arise from recessive and dominant gene mutations. Gene replacement strategies may be beneficial for the former, while gene silencing approaches may provide treatment for the latter. In the last two decades, muscle-directed gene therapies were primarily focused on treating recessive disorders. This disparity at least partly arose because feasible mechanisms to silence dominant disease genes lagged behind gene replacement strategies. With the discovery of RNA interference (RNAi) and its subsequent development as a promising new gene silencing tool, the landscape has changed. In this study, our objective was to demonstrate proof-of-principle for RNAi therapy of a dominant myopathy in vivo. We tested the potential of adeno-associated viral (AAV)-delivered therapeutic microRNAs, targeting the human Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1), to correct myopathic features in mice expressing toxic levels of human FRG1 (FRG1(-high) mice). We found that FRG1 gene silencing improved muscle mass, strength, and histopathological abnormalities associated with muscular dystrophy in FRG1(-high) mice, thereby demonstrating therapeutic promise for treatment of dominantly inherited myopathies using RNAi. This approach potentially applies to as many as 29 different gene mutations responsible for myopathies inherited as dominant disorders
A Harper Trophy Book
No full textSee the original of this book, done by Thomas Y. Crowell in 1975. This edition seems identical to that except for the new line added to the title-page mentioning that it is a Harper Trophy Book. As I wrote there, this is a cute, clever, lively book. The illustrations are done with imagination. Unfortunately, the two Aesop's fables (LM and DS) do not receive drawings as good as the rest. Compare Rockwell's later work on LaFontaine, The Turtle and the Two Ducks (1981). The stories here are well told.This is a hardbound book (hard cover)Anne Rockwel
A Harper Trophy Book
No full textThis book represents the fifth form in which this publication appears in the collection. Two hardbound and one paperbound edition came out from Crowell in 1975. In 1984 a new edition came out with the sole change, apparently, that it is a Harper Trophy Book. This is that edition done in a green library binding. As I wrote earlier, this is a cute, clever, lively book. The illustrations are done with imagination. Unfortunately, the two Aesop's fables (LM and DS) do not receive drawings as good as the rest. Compare Rockwell's later work on LaFontaine, The Turtle and the Two Ducks (1981). The stories here are well told.This is a hardbound book (hard cover)Anne Rockwel
Markets Equilibrium: The Is-Lm Model
No full text. The purpose of this study is to analyze how the concept of markets equilibrium: the IS-LM Model. This research uses library research method by using reference sources from books and journals according to the theme. The author uses a qualitative method which is explained graphically, namely the market balance of the IS-LM model where the focus is on money and goods markets associated with macroeconomics where researchers take the side of investors. The results of this study are that the balance in the economy is the point where the IS and LM curves intersect. This point provides an interest rate (r) and income level (Y) that satisfies the equilibrium conditions that occur in the goods market and money market. In other words, planned spending equals actual spending, and the demand for real money balances equals the supply. So that the IS-LM balance, it is stated that IS=LM
The History of Macroeconomics Viewed Against the Background of the Marshall-Walras Divide
No full textAnalysing the recent history of macroeconomics, my paper claims that the new classical revolution should be viewed as a substitution of Walrasian macroeconomics to the earlier prevailing Marshalian macroeconomics. The first part of the paper is concerned with two conceptual prerequisites, the relationship between macroeconomics and general equilibrium, the meaning of the “Keynesianism” modifier. In a second part, the different facets of the Marshall-Walras divide are expounded. My general claim is substantiated in the third paper of the paper. Herein, I claim that the IS-LM model is a simplified Marshallian general equilibrium model while real business cycle models belong to the Walrasian reserach programme. Finally, I express my scepticism as to the possibility of a New Neoclassical Synthesis.History of macroeconomics; Neoclassical Synthesis; New Neoclassical Synthesis; Keynesianism; Monetarism
The Tall Book of Nursery Tales
No full textThis book may be notable mostly for its unusual shape and for the variation of colored and black-and-white illustrations, which are uninspired. Includes TMCM, MM, BW, FC, TH, LM, and GGE. There are two other versions of this book in the collection. This edition, perhaps later than one found at Midway in November, 1994, does not mention Harper on the cover, places Harper on the title-page not in New York and London but rather in New York and Evanston, and mentions Western Printing and Lithographing on the verso of its title-page. This version also adds plain pages before the title-page and illustrated interior of a house with a book and ball and windows looking out on children reading and playing. One of these illustration papers here is torn.This is a hardbound book (hard cover
The Tall Book of Nursery Tales
No full textThis book may be notable mostly for its unusual shape and for the variation of colored and black-and-white illustrations, which are uninspired. Includes TMCM, MM, BW, FC, TH, LM, and GGE. There are two other versions of this book in the collection. This edition, perhaps later than one found at Midway in November, 1994, does not mention Harper on the cover, places Harper on the title-page not in New York and London but rather in New York and Evanston, and mentions Western Printing and Lithographing on the verso of its title-page. This version uses as its end-papers an illustrated interior of a house with a book and ball and windows looking out on children reading and playing.This is a hardbound book (hard cover
<Articles>A Dynamical IS-LM Model
No full text[抄録]IS-LM モデルは、ヒックスによるケインズ経済学の因果関係を重視しながら要約したモデルと解釈することができる。IS-LM モデルの安定性分析はすでに研究成果があるが、1S-LM モデルの動学化はほとんど研究成果がない。本稿は IS-LM モデルの動学化を試みる。まず投資関数に資本ストックを取り入れ、資本蓄積と経済の変動を考える。次にカルドアモデルを考慮し、投資の予想収益率表の変化を仮定し、経済に循環が発生することを考察する。
[Abstract]In this paper, The author tries to build a Dynamical IS-LM Model. The lnvestment depends on two factors, one is the rate of interest, and the other is the rate of prosperity yield of the investment. I will focus on the second factor. As was shown by Kaldor, the rate of prosperity yield has nonlinear fluctuations. By means of this character, This study proposes an IS-LM model that generates a cycle.departmental bulletin pape
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