1,744 research outputs found
Molecular detection and significance of circulating colorectal cancer cells / Jennifer E. Hardingham.
No full textBibliography: leaves 214-236.xviii, 238 leaves : ill. (some col.) ; 30 cm.Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 199
Ep. #136 - Jennifer Gabrys
No full textThis recording and transcript form part of a collection of podcasts conducted by the Cultures of Energy at Rice University. Cultures of Energy brings writers, artists and scholars together to talk, think and feel their way into the Anthropocene. We cover serious issues like climate change, species extinction and energy transition. But we also try to confront seemingly huge and insurmountable problems with insight, creativity and laughter.Your cohosts discuss what sensory technologies they might wish for their own home and the kind of multispecies encounters Cymene might have had in a Tegucigalpa red light district hotel (trigger warning: there be cockroach stories ahead!) Then (20:29) we chat with the multitalented Jennifer Gabrys from Goldsmiths (https://www.jennifergabrys.net), author most recently of Program Earth (U Minnesota Press, 2016), and her fascinating work on the spread of environmental sensing technologies and the impacts they are having on our worlds. Jennifer explains to us why she became taken with Whitehead’s concept of the “superject” as a different, more distributed and relational way of thinking about sensation and experience. That gets us to talking about nonhuman modes of sensing, what humans want from all these sensors, the problem of environmentality in smart city designs, computational urbanism, and why the figure of the idiot interests her in terms of thinking about models of digital participation. Jennifer explains how we can be for a world (and for other worlds) rather than simply of the world and why the etho-ecological is thus such an interesting domain for her. In closing, we return to Jennifer’s pathbreaking work on digital waste and the need for electronic environmentalism and talk about the e-waste/energy nexus and the paradox of spending ever more energy to monitoring ourselves using more energy. Listen on
Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis
No full textOlfactomedin 4 (OLFM4), a member of the olfactomedin domain-containing proteins, is a glycoprotein with molecular weight of approximately 64 kDa. The protein is a "robust marker" of Lgr5+ stem cells and has been localised to mitochondria, nuclei and cell membranes. The bulk of OLFM4 exists in a polymeric form which is held together by disulfide bonds and carbohydrate interactions. Earlier studies revealed that the protein binds to lectins and cadherins, and facilitates cell-cell adhesion. Recent data demonstrated that the protein possesses several hallmarks of carcinogenesis. OLFM4 has also been purported to be an inducible resistance factor to apoptotic stimuli such as radiation and anticancer drugs. Here, we review its synonyms and classification, gene structure, protein structure, intracellular and tissue distribution, adhesive and antiapoptotic; mitotic; migratory and cell cycle regulatory characteristics. We also critically evaluate recent advances in understanding of the transcriptional regulation of OLFM4 and its upstream signalling pathways with special emphasis on carcinogenesis and outline future perspectives in the field.Phulwinder K. Grover, Jennifer E. Hardingham, Adrian G. Cummin
Cult: A Composite Novel
No full textCult (redacted)
The first component of the thesis is a composite novel called Cult which falls into two parts with seven narratives in each. Part 1 tracks the protagonist, Ellen, from her first involvement with the cult through to her eventually leaving it. Although fiction, the first half of the book answers the kinds of questions the author is asked when people discover that she was once a sannyasin (a follower of the guru Bhagwan Shree Rajneesh). While the experiences of meditation, group therapy and communal living are all faithfully rendered within the stories, the need for strong characters, narrative drive and a lightness of touch takes precedence.
Part 2 picks up Ellen’s story some twenty or so years later and explores what becomes of her in middle age. It also looks at other groups in society, such as academia, the law and the internet dating community which each have their own jargon, hierarchies, rituals and rules but are not considered to be cults.
The book examines the question raised in the Epigraph, ‘how do we be together when we feel so alone’ with a focus on relationships other than the familial and the romantic.
Collisions, Chasms and Connections: a Performative Exploration of the Composite Novel Form
The second part of the thesis is both a critical and creative response to three contemporary American books: Olive Kitteridge by Elizabeth Strout; A Visit from the Goon Squad by Jennifer Egan; and Legend of a Suicide by David Vann. The critical element comprises a close reading of the three books; a chronological reconstruction of their overarching storylines; and a consideration of what their authors have said about writing the books. It concludes that, in the composite novel, the simultaneous presentation of multiple views and storylines operate much like a 3D image to give the impression of depth to the characters and situations rendered. The creative element of the essay is a playful and personal response to the texts
A cross-cultural test of the relational turbulence model: Relationship characteristics that predict turmoil and topic avoidance for Koreans and Americans
No full textThis study models associations among intimacy, relational uncertainty, partner interference, relational turmoil, and topic avoidance in Korean and American romantic relationships. We surveyed 294 individuals from the United States (N = 156) and South Korea (N = 138). The American model indicated that intimacy was negatively associated with relational uncertainty and curvilinearly associated with partner interference, relational uncertainty was positively associated with topic avoidance, and partner interference was positively associated with perceived turmoil. The South Korean model revealed that intimacy was negatively associated with relational uncertainty, both relational uncertainty and partner interference were positively associated with perceived turmoil, which was positively associated with topic avoidance. Although the American and Korean models were statistically invariant, some notable cultural differences are discussed.Peer reviewe
Tagging of Biomedical Articles on CiteULike: A Comparison of User, Author and Professional Indexing
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and professional indexers. User tags, author keywords and descriptors were collected from academic journal articles, which were both indexed in Pubmed and tagged on CiteULike, and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the use of keywords between the three groups in addition to similarities which can be used to enhance support for search and browse. While tags and author keywords were found that matched descriptors exactly, other terms which did not match but provided important expansion to the indexing lexicon were found. These additional terms could be used to enhance support for searching and browsing in article databases as well as to provide invaluable data for entry vocabulary and emergent terminology for regular updates to indexing systems. Additionally, the study suggests that tags support organisation by association to task, projects and subject while making important connections to traditional systems which classify into subject categories
Resource sustainability: Practices and promises : a document submitted in partial fulfillment ... for the degrees of Master of Science (Natural Resources) and Master of Science (Water Resources Management) ...
No full textTania E. Hurie, Melissa M. Nagel, Jennifer E. Puntenney, Nompumelelo Tshabalala, Tara E. Ward, Wendy A. Woods, with Almut Beringer, Nandita Jain.; Thesis equivalent (M.S.)--University of Michigan, 1989
Differential inhibition of water and ion channel activities of mammalian aquaporin-1 by two structurally related bacopaside compounds derived from the medicinal plant bacopa monnieri
No full textAquaporin-1 (AQP1) is a major intrinsic protein that facilitates flux of water and other small solutes across cell membranes. In addition to its function as a water channel in maintaining fluid homeostasis, AQP1 also acts as a nonselective cation channel gated by cGMP, a property shown previously to facilitate rapid cell migration in a AQP1-expressing colon cancer cell line. Here we report two new modulators of AQP1 channels, bacopaside I and bacopaside II, isolated from the medicinal plant Bacopa monnieri Screening was conducted in the Xenopus oocyte expression system, using quantitative swelling and two-electrode voltage clamp techniques. Results showed bacopaside I blocked both the water (IC50 117 μM) and ion channel activities of AQP1 but did not alter AQP4 activity, whereas bacopaside II selectively blocked the AQP1 water channel (IC50 18 μM) without impairing the ionic conductance. These results fit with predictions from in silico molecular modeling. Both bacopasides were tested in migration assays using HT29 and SW480 colon cancer cell lines, with high and low levels of AQP1 expression, respectively. Bacopaside I (IC50 48 μM) and bacopaside II (IC50 14 μM) impaired migration of HT29 cells but had minimal effect on SW480 cell migration. Our results are the first to identify differential AQP1 modulators isolated from a medicinal plant. Bacopasides could serve as novel lead compounds for pharmaceutic development of selective aquaporin modulators.Jinxin V. Pei, Mohamad Kourghi, Michael L. De Ieso, Ewan M. Campbell, Hilary S. Dorward, Jennifer E. Hardingham and Andrea J. Yoo
E-journals in a networked environment : its impact on academic libraries in the digital millennium
No full textThis paper tries to describe the Advantages of E-journals in terms of Accessibility, Speed distribution and production, Subscription Cost, Multimedia Capabilities, Internal and External Links etc and also tries to find out the Technological, Socio-cultural and Economic Barriers. The issues like Refereeing, Copyright and Licensing, Longevity and Storage and recent trends in E-journal publication and its implication on Academic Libraries in selection and acquisition, Cataloguing, archiving, user's access, training and support to staff and users are discussed in this paper
G. Petrone, Quando le Muse parlavano latino. Studi su Plauto, Bologna 2009, “Aevum” 85, 2011, pp. 223-225
No full textThe author collected her articles with a bibliographical revisio
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