5 research outputs found
A Novel Locus of Ectodermal Dysplasia Maps to Chromosome 10q24.32–q25.1
No full textEctodermal dysplasia (ED) represents a heterogeneous group of genetic disorders characterized by the absence or deformity in two or more of the ectodermal appendages. We have studied an autosomal recessive form of ED in 13 individuals over six generations from an inbred Pakistani family. The clinical features of the affected individuals include highly dystrophic nails and thin hair on scalp, fine eyebrows and eyelashes, and thin body hair. Genome-wide linkage analysis of 390 microsatellite markers mapped the ED gene to the 3.92 cM interval flanked by markers D10S1710 and D10S1741 on chromosome 10q24.32–q25.1. Multipoint linkage analysis generated a maximum logarithm of odds ratio score of 4.79 in the interval D10S1239–D10S1264, which corresponds to 6.35 Mb
A novel autosomal recessive non-syndromic deafness locus (DFNB35) maps to 14q24.1–14q24.3 in large consanguineous kindred from Pakistan
No full textLocalization of A Novel Autosomal Recessive Non-Syndromic Hearing Impairment Locus (DFNB38) to 6q26-q27 in a Consanguineous Kindred from Pakistan
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Seroprevalence of Acute Hepatitis Caused by HAV & HEV in Gazipur, Bangladesh.
No full textHepatitis A and E virus (HAV & HEV) are the most common causes of acute hepatitis. Both of them are endemic in South Asia; specially in the developing countries, like Bangladesh. This study was undertaken to determine the prevalence, age-specific prevalence and seasonal variation of Hepatitis A and Hepatitis E in Gazipur district. This cross-sectional study was conducted in 1118 patients presenting with acute viral hepatitis. All patients were tested for Anti-HAV IgM and Anti-HEV IgM by Enzyme Linked Immunosorbent Assay (ELISA) method. The study population was divided into 7 groups according to their ages with 10 years interval. Among 1118 patients, 571(51.0%) & 203 (18.2%) were found HEV IgM positive and HAV IgM respectively. Rest 344 (30.8%) patients were negative for both HAV IgM & HEV IgM. 64.0% and 77.8% male patients were positive for HAV and HEV infection. In our study, it was found that 62.4% patients positive for Hepatitis A infection were less than 10 years and 73.9% & 70.5% HEV positive patients were in 31 years to 40 years and 41 years to 50 years age group. HAV & HEV infections occur all year round with a peak during hot seasons with great number of rains. It may be concluded with that both HAV & HEV infection can occur at any age throughout the year. But HAV affect more in children and HEV affect more in adults with a peak during hot seasons with great number of rains
