133,782 research outputs found
Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma
No full textBackground: Hodkin s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as potential therapeutic target structure in Hodgkin s lymphoma as well as in non Hodgkin s lymphoma.
Methods: We used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of Hodgkin s lymphoma and 138 cases on several non Hodgkin s lymphoma entities.
Results: Vitamin D receptor is strongly expressed in Hodgkin s lymphoma, regardless of the subentity with an overall positivity of 80% of all Hodgkin lymphoma cases. In contrast, only about 17% of the analyzed non Hodgkin s lymphoma of B-cell origin showed positivity for vitamin D receptor. Predominant nuclear localization of vitamin D receptor in Hodgkin s lymphoma suggests activated status of the vitamin D receptor.
Conclusions: From this study, we conclude that vitamin D receptor plays a potentially important role in pathogenesis of Hodgkin s lymphoma but not in non Hodgkin s lymphoma. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in Hodgkin s lymphoma
Mercato, concorrenza e regole nel sistema universitario italiano. Riflessioni in margine ad un articolo di H. Hansmann
No full textIn a recent article published in this journal, Henry Hansmann deals with the quality of higher education of the Italian university system. In this paper we reconsider Hansmann’s proposals by taking into account the Italian institutional framework and the recent normative innovations. At present ì, the Ministry no longer has complete control over universities, as a large amount of autonomy has been already granted and the university faculty has a much stronger influence on the governing of individual universities. To complete this process of reform, what is now necessary is to pursue a more resolute deregulation of the sector, to increase the number of institutions, and to re-design the internal decisional structures. The State should act so as to transform State universities into non-profit institutions or even to favour the rise of autonomous regional university systems
Dominique Girard und Antoine Joseph Dezallier d'Argenville über d. Kunst, Parterres zu gestalten
No full textMeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
SIMULATION OF AN ENSEMBLE WITH VARYING MAGNETIC-FIELD - A NUMERICAL DETERMINATION OF THE ORDER-ORDER INTERFACE TENSION IN THE D=2 ISING-MODEL
No full textBERG BA, HANSMANN U, Neuhaus T. SIMULATION OF AN ENSEMBLE WITH VARYING MAGNETIC-FIELD - A NUMERICAL DETERMINATION OF THE ORDER-ORDER INTERFACE TENSION IN THE D=2 ISING-MODEL. PHYSICAL REVIEW B. 1993;47(1):497-500.In analogy with a recently proposed multicanonical ensemble we introduce an ensemble where the partition function is simulated with a term in the action containing a varying magnetic field. Using this ensemble we demonstrate on lattices with periodic boundary conditions that it is possible to enhance the appearance of order-order interfaces by many orders of magnitude. To perform a stringent test of the method we consider the D = 2 Ising model at beta = 0.5 and simulate square lattices up to size 100 x 100. By a finite-size scaling analysis, the order-order interface tension per unit area is obtained. Our best infinite-volume extrapolation is in excellent agreement with Onsager's exact result
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Scholarly Communication and Publishing Lunch and Learn Talk #11: The ULS Open Access Author Fee Fund
No full textAt the May 2014 talk, you will learn about the ULS Open Access Author Fee Fund--what it is, why we do it, how it works, and how the program is going so far
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